{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:38:12Z","timestamp":1792449492041,"version":"4.5.0"},"reference-count":89,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2021,5,22]],"date-time":"2021-05-22T00:00:00Z","timestamp":1621641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2019R1A2C1007218"],"award-info":[{"award-number":["2019R1A2C1007218"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Polydeoxyribonucleotides (PDRNs) are a family of DNA-derived drugs with a molecular weight ranging from 50 to 1500 kDa, which are mainly extracted from the sperm cells of salmon trout or chum salmon. Many pre-clinical and clinical studies have demonstrated the wound healing and anti-inflammatory properties of PDRN, which are mediated by the activation of adenosine A2A receptor and salvage pathways, in addition to promoting osteoblast activity, collagen synthesis, and angiogenesis. In fact, PDRN is already marketed due to its therapeutic properties against various wound healing- and inflammation-related diseases. Therefore, this review assessed the most recent trends in marine organism-derived PDRN using the Google Scholar search engine. Further, we summarized the current applications and pharmacological properties of PDRN to serve as a reference for the development of novel PDRN-based technologies.<\/jats:p>","DOI":"10.3390\/md19060296","type":"journal-article","created":{"date-parts":[[2021,5,23]],"date-time":"2021-05-23T23:58:05Z","timestamp":1621814285000},"page":"296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Applications of Marine Organism-Derived Polydeoxyribonucleotide: Its Potential in Biomedical Engineering"],"prefix":"10.3390","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0988-0193","authenticated-orcid":false,"given":"Tae-Hee","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Yeong","family":"Heo","sequence":"additional","affiliation":[{"name":"Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gun-Woo","family":"Oh","sequence":"additional","affiliation":[{"name":"Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jin","family":"Heo","sequence":"additional","affiliation":[{"name":"Jeju Marine Research Center, Korea Institute of Ocean Science & Technology (KIOST), Jeju 63349, Korea"},{"name":"Department of Marine Biology, Korea University of Science and Technology, Deajeon 34113, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1615-750X","authenticated-orcid":false,"given":"Won-Kyo","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering and New-Senior Healthcare Innovation Center (BK21 Plus), Pukyong National University, Busan 48513, Korea"},{"name":"Research Center for Marine Integrated Bionics Technology, Pukyong National University, Busan 48513, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3389\/fphar.2016.00273","article-title":"Adenosine receptor stimulation by polydeoxyribonucleotide improves tissue repair and symptomology in experimental colitis","volume":"7","author":"Pallio","year":"2016","journal-title":"Front. 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