{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T23:43:49Z","timestamp":1788479029448,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T00:00:00Z","timestamp":1626220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A2001"],"award-info":[{"award-number":["U20A2001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21877133"],"award-info":[{"award-number":["21877133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Key-Area Research and Development Program of Guangdong Province","award":["2020B1111030005"],"award-info":[{"award-number":["2020B1111030005"]}]},{"name":"the National Key R&amp;D Program of China","award":["2019YFC0312501"],"award-info":[{"award-number":["2019YFC0312501"]}]},{"name":"the Key Project of Natural Science Foundation of Guangdong Province","award":["2016A030311026"],"award-info":[{"award-number":["2016A030311026"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Three new metabolites, furobenzotropolones A, B (1\u20132) with unusual benzene and dihydrofuran moieties and 3-hydroxyepicoccone B (3), together with seven known compounds (4\u201310) were obtained from the endophytic fungus Epicoccum nigrum MLY-3 isolated from the fresh leaf of mangrove plant Bruguiear gymnorrhiza collected from Zhuhai. Their structures were assigned by the analysis of UV, IR, NMR, and mass spectroscopic data. Compound 1 was further confirmed by single-crystal X-ray diffraction experiment using Cu K\u03b1 radiation. In antioxidant activities in vitro, compounds 2, 3, 5, and 8 showed promising DPPH\u00b7 scavenging activity with IC50 values ranging from 14.7 to 29.3 \u00b5M. Compounds 2, 3, 5, 7, and 8 exhibited promising potent activity in scavenging ABTS\u00b7 with IC50 values in the range of 18\u201329.2 \u00b5M, which was stronger than that of the positive control ascorbic acid (IC50 = 33.6 \u00b1 0.8 \u00b5M).<\/jats:p>","DOI":"10.3390\/md19070395","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T10:13:42Z","timestamp":1626257622000},"page":"395","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Furobenzotropolones A, B and 3-Hydroxyepicoccone B with Antioxidative Activity from Mangrove Endophytic Fungus Epicoccum nigrum MLY-3"],"prefix":"10.3390","volume":"19","author":[{"given":"Ge","family":"Zou","sequence":"first","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Tan","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"},{"name":"National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-0332","authenticated-orcid":false,"given":"Wencong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Zang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenyu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-6701","authenticated-orcid":false,"given":"Zhigang","family":"She","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1039\/B711474E","article-title":"A Fresh Look at Natural Tropolonoids","volume":"25","author":"Bentley","year":"2008","journal-title":"Nat. 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