{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:38:00Z","timestamp":1792805880511,"version":"4.5.0"},"reference-count":24,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T00:00:00Z","timestamp":1627430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFC0312503"],"award-info":[{"award-number":["2019YFC0312503"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016098","name":"Special Project for Marine Economy Development of Guangdong Province","doi-asserted-by":"publisher","award":["GDNRC2021052"],"award-info":[{"award-number":["GDNRC2021052"]}],"id":[{"id":"10.13039\/100016098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20101, 81973235, 21977102"],"award-info":[{"award-number":["U20A20101, 81973235, 21977102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012692","name":"K. C. Wong Education Foundation","doi-asserted-by":"publisher","award":["GJTD-2020-12"],"award-info":[{"award-number":["GJTD-2020-12"]}],"id":[{"id":"10.13039\/501100012692","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)","award":["GML2019ZD0406"],"award-info":[{"award-number":["GML2019ZD0406"]}],"id":[{"id":"https:\/\/ror.org\/00y7mag53","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Guangdong Local Innovation Team Program","award":["2019BT02Y262"],"award-info":[{"award-number":["2019BT02Y262"]}]},{"name":"Guangdong Basic and Applied Basic Research Foundation","award":["2019B151502042"],"award-info":[{"award-number":["2019B151502042"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The mangrove-sediment-derived actinomycete strain Streptomyces\u00a0psammoticus SCSIO NS126 was found to have productive piericidin metabolites featuring anti-renal cell carcinoma activities. In this study, in order to explore more diverse piericidin derivatives, and therefore to discover superior anti-tumor lead compounds, the NS126 strain was further fermented at a 300-L scale under optimized fermentation conditions. As a result, eight new minor piericidin derivatives (piericidins L-R (1\u20137) and 11-demethyl-glucopiericidin A (8)) were obtained, along with glucopiericidin B (9). The new structures including absolute configurations were determined by spectroscopic methods coupled with experimental and calculated electronic circular dichroism. We also proposed plausible biosynthetic pathways for these unusual post-modified piericidins. Compounds 1 and 6 showed selective cytotoxic activities against OS-RC-2 cells, and 2\u20135 exhibited potent cytotoxicity against HL-60 cells, with IC50 values lower than 0.1 \u03bcM. The new piericidin glycoside 8 was cytotoxic against ACHN, HL-60 and K562, with IC50 values of 2.3, 1.3 and 5.5 \u03bcM, respectively. The ability to arrest the cell cycle and cell apoptosis effects induced by 1 and 6 in OS-RC-2 cells, 2 in HL-60 cells, and 8 in ACHN cells were then further investigated. This study enriched the structural diversity of piericidin derivatives and confirmed that piericidins deserve further investigations as promising anti-tumor agents.<\/jats:p>","DOI":"10.3390\/md19080428","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T11:12:52Z","timestamp":1627470772000},"page":"428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cytotoxic Minor Piericidin Derivatives from the Actinomycete Strain Streptomyces\u00a0psammoticus SCSIO NS126"],"prefix":"10.3390","volume":"19","author":[{"given":"Kunlong","family":"Li","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"},{"name":"College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Su","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Gao","sequence":"additional","affiliation":[{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"},{"name":"Institutional Center for Shared Technologies and Facilities, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuping","family":"Lin","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Pang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-1345","authenticated-orcid":false,"given":"Huaming","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-1609","authenticated-orcid":false,"given":"Xiaowei","family":"Luo","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"},{"name":"College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-4869","authenticated-orcid":false,"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1039\/C9NP00069K","article-title":"Marine natural products","volume":"37","author":"Carroll","year":"2020","journal-title":"Nat. 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