{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:04:02Z","timestamp":1790309042395,"version":"4.1.0"},"reference-count":86,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFD0900902"],"award-info":[{"award-number":["2020YFD0900902"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The intestinal flora is recognized as a significant contributor to the immune system. In this research, the protective effects of oyster peptides on immune regulation and intestinal microbiota were investigated in mice treated with cyclophosphamide. The results showed that oyster peptides restored the indexes of thymus, spleen and liver, stimulated cytokines secretion and promoted the relative mRNA levels of Th1\/Th2 cytokines (IL-2, IFN-\u03b3, IL-4 and IL-10). The mRNA levels of Occludin, Claudin-1, ZO-1, and Mucin-2 were up-regulated, and the NF-\u03baB signaling pathway was also activated after oyster peptides administration. Furthermore, oyster peptides treatment reduced the proportion of Firmicutes\/Bacteroidetes, increased the relative abundance of Alistipes, Lactobacillus, Rikenell and the content of short-chain fatty acids, and reversed the composition of intestinal microflora similar to that of normal mice. In conclusion, oyster peptides effectively ameliorated cyclophosphamide-induced intestinal damage and modified gut microbiota structure in mice, and might be utilized as a beneficial ingredient in functional foods for immune regulation.<\/jats:p>","DOI":"10.3390\/md19080456","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T02:14:41Z","timestamp":1628648081000},"page":"456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Ameliorative Effects of Peptides Derived from Oyster (Crassostrea gigas) on Immunomodulatory Function and Gut Microbiota Structure in Cyclophosphamide-Treated Mice"],"prefix":"10.3390","volume":"19","author":[{"given":"Xing-Wei","family":"Xiang","sequence":"first","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"},{"name":"Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Zhen","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"},{"name":"Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"},{"name":"Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"},{"name":"Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Xing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Ocean Research Center of Zhoushan, Zhejiang University, Zhoushan 316000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6416-5897","authenticated-orcid":false,"given":"Shu-Lai","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"},{"name":"Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Ting","family":"Ding","sequence":"additional","affiliation":[{"name":"College of Food Science and Technology, Zhejiang University of Technology, Hangzhou 310014, China"},{"name":"Key Laboratory of Marine Fishery Resources Exploitment & Utilization of Zhejiang Province, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jaut.2009.09.008","article-title":"Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases","volume":"33","author":"Cooper","year":"2009","journal-title":"J. Autoimmun."},{"key":"ref_2","first-page":"128","article-title":"Comparison of cancer incidence between China and the USA","volume":"9","author":"Wang","year":"2012","journal-title":"Cancer Biol. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrclinonc.2009.146","article-title":"Cyclophosphamide and cancer: Golden anniversary","volume":"6","author":"Emadi","year":"2009","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejphar.2013.06.006","article-title":"The changes induced by cyclophosphamide in intestinal barrier and microflora in mice","volume":"714","author":"Yang","year":"2013","journal-title":"Eur. J. Pharmacol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.micres.2014.11.002","article-title":"Effects of cyclophosphamide on immune system and gut microbiota in mice","volume":"171","author":"Xu","year":"2015","journal-title":"Microbiol. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.biotechadv.2015.08.001","article-title":"Discovery and resupply of pharmacologically active plant-derived natural products: A review","volume":"33","author":"Atanasov","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Kiewiet, M.B.G., Faas, M.M., and de Vos, P. (2018). Immunomodulatory protein hydrolysates and their application. Nutrients, 10.","DOI":"10.3390\/nu10070904"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"436","DOI":"10.12968\/denu.2017.44.5.436","article-title":"The immune system: Basis of so much health and disease: 4. immunocytes","volume":"44","author":"Scully","year":"2017","journal-title":"Dent. Update"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-57613-8_1","article-title":"The role of the immune system beyond the fight against infection","volume":"1003","author":"Sattler","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.foodhyd.2018.11.018","article-title":"Polysaccharide from natural cordyceps sinensis ameliorated intestinal injury and enhanced antioxidant activity in immunosuppressed mice","volume":"89","author":"Chen","year":"2019","journal-title":"Food Hydrocoll."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/978-94-017-9487-9_3","article-title":"Th1\/Th2 cell\u2019s function in immune system","volume":"841","author":"Zhang","year":"2014","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.3389\/fimmu.2019.02842","article-title":"The essential role played by B cells in supporting protective immunity against trichuris muris infection is by controlling the Th1\/Th2 balance in the mesenteric lymph nodes and depends on host genetic background","volume":"10","author":"Sahputra","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_13","first-page":"6012473","article-title":"Shashen-maidong decoction-mediated IFN-\u03b3 and IL-4 on the regulation of Th1\/Th2 imbalance in RP rats","volume":"2019","author":"Yang","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115957","DOI":"10.1016\/j.carbpol.2020.115957","article-title":"Cultured cordyceps sinensis polysaccharides modulate intestinal mucosal immunity and gut microbiota in cyclophosphamide-treated mice","volume":"235","author":"Ying","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.immuni.2018.07.015","article-title":"Regulatory T cells promote macrophage efferocytosis during inflammation resolution","volume":"49","author":"Proto","year":"2018","journal-title":"Immunity"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"103420","DOI":"10.1016\/j.jff.2019.103420","article-title":"Immunomodulatory effects of collagen hydrolysates from yak (bos grunniens) bone on cyclophosphamide-induced immunosuppression in BALB\/c mice","volume":"60","author":"Gao","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1600-065X.2007.00523.x","article-title":"Human mast cells, bacteria, and intestinal immunity","volume":"217","author":"Bischoff","year":"2007","journal-title":"Immunol. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.anaerobe.2015.01.004","article-title":"High-throughput 16S rRNA gene sequencing reveals alterations of mouse intestinal microbiota after radiotherapy","volume":"33","author":"Kim","year":"2015","journal-title":"Anaerobe"},{"key":"ref_19","first-page":"152428","article-title":"Autoimmunity and the gut","volume":"2014","author":"Campbell","year":"2014","journal-title":"Autoimmune Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4735040","DOI":"10.1155\/2019\/4735040","article-title":"Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity","volume":"2019","author":"Wang","year":"2019","journal-title":"J. Immunol Res."},{"key":"ref_21","first-page":"2411","article-title":"Treatment with subcritical water-hydrolyzed citrus pectin ameliorated cyclophosphamide-induced immunosuppression and modulated gut microbiota composition in ICR mice","volume":"25","author":"Chen","year":"2020","journal-title":"Molecules"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4161\/gmic.29330","article-title":"The interplay between the gut microbiota and the immune system","volume":"5","author":"Geuking","year":"2014","journal-title":"Gut Microbes"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/cei.12474","article-title":"Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota","volume":"179","author":"Peterson","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1053\/j.gastro.2014.01.060","article-title":"Regulation of the immune system by the resident intestinal bacteria","volume":"146","author":"Kamada","year":"2014","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.fsi.2019.03.035","article-title":"Immunosuppression-induced alterations in fish gut microbiota may increase the susceptibility to pathogens","volume":"88","author":"Qi","year":"2019","journal-title":"Fish Shellfish Immunol."},{"key":"ref_26","first-page":"1","article-title":"Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)","volume":"66","author":"Ratajczak","year":"2019","journal-title":"Acta Biochim. Pol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.ijbiomac.2018.04.004","article-title":"Protective properties of combined fungal polysaccharides from cordyceps sinensis and ganoderma atrum on colon immune dysfunction","volume":"114","author":"Fan","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.cofs.2014.09.005","article-title":"Bioactive peptides and protein hydrolysates: Research trends and challenges for application as nutraceuticals and functional food ingredients","volume":"1","year":"2015","journal-title":"Curr. Opin. Food Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/10408398.2013.873766","article-title":"Dietary bioactive peptides: Human studies","volume":"57","author":"Bouhallab","year":"2017","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"608979","DOI":"10.1155\/2014\/608979","article-title":"Food-derived bioactive peptides on inflammation and oxidative stress","volume":"2014","author":"Chakrabarti","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.foodchem.2017.10.087","article-title":"Immunomodulatory and anticancer protein hydrolysates (peptides) from food proteins: A review","volume":"245","author":"Chalamaiah","year":"2018","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.idairyj.2007.07.008","article-title":"Immunomodulating properties of a whey protein isolate, its enzymatic digest and peptide fractions","volume":"18","author":"Gauthier","year":"2008","journal-title":"Int. Dairy J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.3168\/jds.2013-6758","article-title":"Immunomodulatory and hypoallergenic properties of milk protein hydrolysates in ICR mice","volume":"96","author":"Pan","year":"2013","journal-title":"J. Dairy Sci."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1039\/C5FO00614G","article-title":"Hydrolysates of egg white proteins modulate T- and B-cell responses in mitogen-stimulated murine cells","volume":"7","author":"Molina","year":"2016","journal-title":"Food Funct."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/jsfa.6859","article-title":"Enzymatic hydrolysis optimization of Paphia undulata and lymphocyte proliferation activity of the isolated peptide fractions","volume":"95","author":"He","year":"2015","journal-title":"J. Sci. Food Agric."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.fsi.2013.02.023","article-title":"Purification of a novel nitric oxide inhibitory peptide derived from enzymatic hydrolysates of Mytilus coruscus","volume":"34","author":"Kim","year":"2013","journal-title":"Fish Shellfish Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00343-013-2311-z","article-title":"Immune functional impacts of oyster peptide-based enteral nutrition formula (OPENF) on mice: A pilot study","volume":"31","author":"Cai","year":"2013","journal-title":"Chin. J. Oceanol. Limnol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3390\/md8020255","article-title":"Oyster (Crassostrea gigas) hydrolysates produced on a plant scale have antitumor activity and immunostimulating effects in BALB\/c mice","volume":"8","author":"Wang","year":"2010","journal-title":"Mar. Drugs"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.foodchem.2012.04.037","article-title":"Antioxidant and antiinflammatory properties of germinated and hydrolysed brazilian soybean flours","volume":"134","author":"Vernaza","year":"2012","journal-title":"Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Caruso, G., Floris, R., Serangeli, C., and Di Paola, L. (2020). Fishery wastes as a yet undiscovered treasure from the sea: Biomolecules sources, extraction methods and valorization. Mar. Drugs, 18.","DOI":"10.3390\/md18120622"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.nut.2013.10.025","article-title":"The immunopotentiating effects of shark-derived protein hydrolysate","volume":"30","author":"Mallet","year":"2014","journal-title":"Nutrition"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"113382","DOI":"10.1016\/j.jep.2020.113382","article-title":"Enzymatic preparation of crassostrea oyster peptides and their promoting effect on male hormone production","volume":"264","author":"Zhang","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"ref_43","first-page":"392","article-title":"Immunomodulatory effect of oyster peptide on immunosuppressed mice","volume":"48","author":"Xu","year":"2016","journal-title":"J. Peking Univ. Health Sci."},{"key":"ref_44","first-page":"14","article-title":"Interaction between the gut microbiome and mucosal immune system","volume":"4","author":"Shi","year":"2017","journal-title":"Mil. Med. Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12026-009-8149-y","article-title":"High-dose cyclophosphamide for autoimmunity and alloimmunity","volume":"47","author":"Brodsky","year":"2010","journal-title":"Immunol. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.autrev.2004.03.002","article-title":"Inflammatory bowel disease: The role of environmental factors","volume":"3","author":"Danese","year":"2004","journal-title":"Autoimmun. Rev."},{"key":"ref_47","first-page":"2032057","article-title":"The effects of secretory IgA in the mucosal immune system","volume":"2020","author":"Li","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Li, Q., Wang, S., Poungchawanwong, S., and Hou, H. (2019). Effect of peptides from alaska pollock on intestinal mucosal immunity function and purification of active fragments. Nutrients, 11.","DOI":"10.3390\/nu11102517"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"595700","DOI":"10.3389\/fimmu.2020.595700","article-title":"Effects of polysaccharides from auricularia auricula on the immuno-stimulatory activity and gut microbiota in immunosuppressed mice induced by cyclophosphamide","volume":"11","author":"Kong","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"a029314","DOI":"10.1101\/cshperspect.a029314","article-title":"Cell biology of tight junction barrier regulation and mucosal disease","volume":"10","author":"Buckley","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1038\/emm.2017.20","article-title":"Roles of intestinal epithelial cells in the maintenance of gut homeostasis","volume":"49","author":"Okumura","year":"2017","journal-title":"Exp. Mol. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"104057","DOI":"10.1016\/j.jff.2020.104057","article-title":"Effects of polysaccharides from bee collected pollen of Chinese wolfberry on immune response and gut microbiota composition in cyclophosphamide-treated mice","volume":"72","author":"Zhao","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1603735","DOI":"10.1155\/2020\/1603735","article-title":"Effects of Polysaccharide from malus halliana koehne flowers in cyclophosphamide-induced immunosuppression and oxidative stress on mice","volume":"2020","author":"Niu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Zhou, X., Dong, Q., Kan, X., Peng, L., Xu, X., Fang, Y., and Yang, J. (2018). Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0204152"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/019262338801600208","article-title":"Immunological functions of the gut\u2014role of the mucosal immune system","volume":"16","author":"Nagura","year":"1988","journal-title":"Toxicol. Pathol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ijbiomac.2021.06.118","article-title":"Immunomodulatory effects of nigella sativa seed polysaccharides by gut microbial and proteomic technologies","volume":"184","author":"Liang","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.ijbiomac.2016.08.021","article-title":"Dietary litchi pulp polysaccharides could enhance immunomodulatory and antioxidant effects in mice","volume":"92","author":"Huang","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Zhou, Y., Chen, X., Yi, R., Li, G., Sun, P., Qian, Y., and Zhao, X. (2018). Immunomodulatory effect of tremella polysaccharides against cyclophosphamide-induced immunosuppression in mice. Molecules, 23.","DOI":"10.3390\/molecules23020239"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Feng, H., Fan, J., Lin, L., Liu, Y., Chai, D., and Yang, J. (2019). Immunomodulatory effects of phosphorylated radix cyathulae officinalis polysaccharides in immunosuppressed mice. Molecules, 24.","DOI":"10.3390\/molecules24224150"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Shin, J.S., Chung, K.S., Han, H.S., Lee, H.H., Lee, J.H., Kim, S.Y., Ji, Y.W., Ha, Y., and Kang, J. (2020). Immunostimulatory effects of live lactobacillus sakei K040706 on the CYP-Induced immunosuppression mouse model. Nutrients, 12.","DOI":"10.3390\/nu12113573"},{"key":"ref_61","first-page":"600","article-title":"Dendrobium sonia polysaccharide regulates immunity and restores the dysbiosis of the gut microbiota of the cyclophosphamide-induced immunosuppressed mice","volume":"17","author":"Liu","year":"2019","journal-title":"Chin. J. Nat. Med."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Fu, Y.P., Feng, B., Zhu, Z.K., Feng, X., Chen, S.F., Li, L.X., Yin, Z.Q., Huang, C., Chen, X.F., and Zhang, B.Z. (2018). The polysaccharides from codonopsis pilosula modulates the immunity and intestinal microbiota of cyclophosphamide-treated immunosuppressed mice. Molecules, 23.","DOI":"10.3390\/molecules23071801"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"103888","DOI":"10.1016\/j.jff.2020.103888","article-title":"Immunomodulatory activity of low molecular-weight peptides from nibea japonica skin in cyclophosphamide-induced immunosuppressed mice","volume":"68","author":"Yu","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"103470","DOI":"10.1016\/j.jff.2019.103470","article-title":"Polysaccharides from the flowers of tea (Camellia sinensis L.) modulate gut health and ameliorate cyclophosphamide-induced immunosuppression","volume":"61","author":"Chen","year":"2019","journal-title":"J. Funct. Foods"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/wsbm.1331","article-title":"Signaling via the NF\u03baB system","volume":"8","author":"Mitchell","year":"2016","journal-title":"Wiley Interdiscip. Rev. Syst. Biol. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijbiomac.2019.02.093","article-title":"Glycosaminoglycan from apostichopus japonicus induces immunomodulatory activity in cyclophosphamide-treated mice and in macrophages","volume":"130","author":"Wang","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Zhang, L., Wei, X., Zhang, R., Koci, M., Si, D., Ahmad, B., Cheng, J., and Wang, J. (2019). Development of a highly efficient hybrid peptide that increases immunomodulatory activity via the TLR4-mediated nuclear factor-kappaB signaling pathway. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20246161"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"104085","DOI":"10.1016\/j.jff.2020.104085","article-title":"Ameliorative effect of low molecular weight peptides from the head of red shrimp (Solenocera crassicornis) against cyclophosphamide-induced hepatotoxicity in mice","volume":"72","author":"Jiang","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.3389\/fimmu.2019.02441","article-title":"Potential role of gut microbiota in induction and regulation of innate immune memory","volume":"10","author":"Negi","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3389\/fimmu.2017.00666","article-title":"Immunomodulatory activities of a fungal protein extracted from hericium erinaceus through regulating the gut microbiota","volume":"8","author":"Diling","year":"2017","journal-title":"Front. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"117668","DOI":"10.1016\/j.carbpol.2021.117668","article-title":"Value added immunoregulatory polysaccharides of hericium erinaceus and their effect on the gut microbiota","volume":"262","author":"Yang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"104219","DOI":"10.1016\/j.jff.2020.104219","article-title":"Immunomodulatory effects of fermented fig (Ficus carica L.) fruit extracts on cyclophosphamide-treated mice","volume":"75","author":"Zhao","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"112305","DOI":"10.1016\/j.fct.2021.112305","article-title":"The effect of microbial composition and proteomic on improvement of functional constipation by chrysanthemum morifolium polysaccharide","volume":"153","author":"Wang","year":"2021","journal-title":"Food Chem. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.molmed.2016.01.002","article-title":"Sulfide as a mucus barrier-breaker in inflammatory bowel disease?","volume":"22","author":"Ijssennagger","year":"2016","journal-title":"Trends Mol. Med."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40168-020-00886-x","article-title":"Microbiota from alginate oligosaccharide-dosed mice successfully mitigated small intestinal mucositis","volume":"8","author":"Zhang","year":"2020","journal-title":"Microbiome"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"11047","DOI":"10.1038\/s41598-017-10369-z","article-title":"Sulfonolipids as novel metabolite markers of alistipes and odoribacter affected by high-fat diets","volume":"7","author":"Walker","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.jff.2018.09.003","article-title":"Immune enhancing effects of weissella cibaria JW15 on BALB\/c mice immunosuppressed by cyclophosphamide","volume":"49","author":"Park","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4014\/jmb.1210.10010","article-title":"Lactobacillus plantarum HY7712 ameliorates cyclophosphamide-induced immunosuppression in mice","volume":"23","author":"Jang","year":"2013","journal-title":"J. Microbiol. Biotechnol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/s41563-019-0462-9","article-title":"Hyaluronic acid-bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis","volume":"19","author":"Lee","year":"2020","journal-title":"Nat. Mater."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"104424","DOI":"10.1016\/j.jff.2021.104424","article-title":"Probiotic-fermented Chinese dwarf cherry [Cerasus humilis (Bge.) Sok.] juice modulates the intestinal mucosal barrier and increases the abundance of akkermansia in the gut in association with polyphenols","volume":"80","author":"Guo","year":"2021","journal-title":"J. Funct. Foods"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1093\/ibd\/izz046","article-title":"Microbiota metabolite butyrate differentially regulates Th1 and Th17 cells\u2019 differentiation and function in induction of colitis","volume":"25","author":"Chen","year":"2019","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1161\/CIRCULATIONAHA.118.036652","article-title":"Short-chain fatty acid propionate protects from hypertensive cardiovascular damage","volume":"139","author":"Bartolomaeus","year":"2019","journal-title":"Circulation"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"11128","DOI":"10.1021\/acs.jafc.0c04253","article-title":"Ascorbic acid derivative 2-O-beta-d-glucopyranosyl-l-ascorbic acid from the fruit of lycium barbarum modulates microbiota in the small intestine and colon and exerts an immunomodulatory effect on cyclophosphamide-treated BALB\/c mice","volume":"68","author":"Huang","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"109433","DOI":"10.1016\/j.foodres.2020.109433","article-title":"Effects of probiotic litchi juice on immunomodulatory function and gut microbiota in mice","volume":"137","author":"Wen","year":"2020","journal-title":"Food Res. Int."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"110393","DOI":"10.1016\/j.foodres.2021.110393","article-title":"Sulfated modification enhances the modulatory effect of yam polysaccharide on gut microbiota in cyclophosphamide-treated mice","volume":"145","author":"Huang","year":"2021","journal-title":"Food Res. Int."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1039\/C9FO01433K","article-title":"Identification and molecular mechanism of antithrombotic peptides from oyster proteins released in simulated gastro-intestinal digestion","volume":"10","author":"Chen","year":"2019","journal-title":"Food Funct."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/19\/8\/456\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:43:49Z","timestamp":1760165029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/19\/8\/456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":86,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["md19080456"],"URL":"https:\/\/doi.org\/10.3390\/md19080456","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,11]]}}}