{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:27:47Z","timestamp":1792506467408,"version":"4.5.0"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The research council of Kermanshah University of Medical Sciences (grant no. 990418)","award":["990418"],"award-info":[{"award-number":["990418"]}]},{"DOI":"10.13039\/501100010095","name":"Hauts-de-France Region","doi-asserted-by":"publisher","award":["STIMulE Exploratoire 2020 project"],"award-info":[{"award-number":["STIMulE Exploratoire 2020 project"]}],"id":[{"id":"10.13039\/501100010095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>In the current paper, we fabricated, characterized, and applied nanocomposite hydrogel based on alginate (Alg) and nano-hydroxyapatite (nHA) loaded with phenolic purified extracts from the aerial part of Linum usitatissimum (LOH) as the bone tissue engineering scaffold. nHA was synthesized based on the wet chemical technique\/precipitation reaction and incorporated into Alg hydrogel as the filler via physical cross-linking. The characterizations (SEM, DLS, and Zeta potential) revealed that the synthesized nHA possess a plate-like shape with nanometric dimensions. The fabricated nanocomposite has a porous architecture with interconnected pores. The average pore size was in the range of 100\u2013200 \u00b5m and the porosity range of 80\u201390%. The LOH release measurement showed that about 90% of the loaded drug was released within 12 h followed by a sustained release over 48 h. The in vitro assessments showed that the nanocomposite possesses significant antioxidant activity promoting bone regeneration. The hemolysis induction measurement showed that the nanocomposites were hemocompatible with negligible hemolysis induction. The cell viability\/proliferation confirmed the biocompatibility of the nanocomposites, which induced proliferative effects in a dose-dependent manner. This study revealed the fabricated nanocomposites are bioactive and osteoactive applicable for bone tissue engineering applications.<\/jats:p>","DOI":"10.3390\/md20010020","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T21:40:21Z","timestamp":1640295621000},"page":"20","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Fabrication and Characterization of Nanocomposite Hydrogel Based on Alginate\/Nano-Hydroxyapatite Loaded with Linum usitatissimum Extract as a Bone Tissue Engineering Scaffold"],"prefix":"10.3390","volume":"20","author":[{"given":"Mahnaz","family":"Mohammadpour","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran 6715847141, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Samadian","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nader","family":"Moradi","sequence":"additional","affiliation":[{"name":"Student\u2019s Research Committee, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah 6714415153, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhila","family":"Izadi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdieh","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3847-4247","authenticated-orcid":false,"given":"Masoud","family":"Hamidi","sequence":"additional","affiliation":[{"name":"BioMatter-Biomass Transformation Lab (BTL), \u00c9cole Polytechnique de Bruxelles, Universit\u00e9 Libre de Bruxelles, Avenue F.D. 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