{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:34:53Z","timestamp":1791516893252,"version":"4.3.4"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Schistosomiasis has been controlled for more than 40 years with a single drug, praziquantel, and only one molluscicide, niclosamide, raising concern of the possibility of the emergence of resistant strains. However, the molecular targets for both agents are thus far unknown. Consequently, the search for lead compounds from natural sources has been encouraged due to their diverse structure and function. Our search for natural compounds with potential use in schistosomiasis control led to the identification of an algal species, Laurencia dendroidea, whose extracts demonstrated significant activity toward both Schistosoma mansoni parasites and their intermediate host snails Biomphalaria glabrata. In the present study, three seaweed-derived halogenated sesquiterpenes, (\u2212)-elatol, rogiolol, and obtusol are proposed as potential lead compounds for the development of anthelminthic drugs for the treatment of and pesticides for the environmental control of schistosomiasis. The three compounds were screened for their antischistosomal and molluscicidal activities. The screening revealed that rogiolol exhibits significant activity toward the survival of adult worms, and that all three compounds showed activity against S. mansoni cercariae and B. glabrata embryos. Biomonitored fractioning of L. dendroidea extracts indicated elatol as the most active compound toward cercariae larvae and snail embryos.<\/jats:p>","DOI":"10.3390\/md20020111","type":"journal-article","created":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:12:56Z","timestamp":1643501576000},"page":"111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Algal-Derived Halogenated Sesquiterpenes from Laurencia dendroidea as Lead Compounds in Schistosomiasis Environmental Control"],"prefix":"10.3390","volume":"20","author":[{"given":"Guilherme Senna","family":"dos Santos","sequence":"first","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-000, SP CEP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Aoki","family":"Miyasato","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-000, SP CEP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3309-1944","authenticated-orcid":false,"given":"Erika Mattos","family":"Stein","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Chemistry Institute, USP\u2014Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-00, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2334-1532","authenticated-orcid":false,"given":"Pio","family":"Colepicolo","sequence":"additional","affiliation":[{"name":"Biochemistry Department, Chemistry Institute, USP\u2014Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-00, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Wright","sequence":"additional","affiliation":[{"name":"DKI College of Pharmacy, University of Hawaii at Hilo, Hilo, HI 96720, USA"},{"name":"Right Consulting, 15 Amauulu Road, Hilo, HI 96720, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-7484","authenticated-orcid":false,"given":"Carlos Alberto de Bragan\u00e7a","family":"Pereira","sequence":"additional","affiliation":[{"name":"Institute of Mathematics and Statistics, USP\u2014Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05503-000, SP CEP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Falkenberg","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Federal University of Santa Catarina, Florian\u00f3polis 88040-970, SC, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7839-9600","authenticated-orcid":false,"given":"Eliana","family":"Nakano","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology, Butantan Institute, S\u00e3o Paulo 05503-000, SP CEP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2012). 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