{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:55Z","timestamp":1790775295811,"version":"4.1.0"},"reference-count":47,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["634674"],"award-info":[{"award-number":["634674"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The biological screening of 44 marine sponge extracts for the research of bioactive molecules, with potential application in the treatment of age-related diseases (cancer and Alzheimer\u2019s disease) and skin aging, resulted in the selection of Scopalina hapalia extract for chemical study. As no reports of secondary metabolites of S. hapalia were found in the literature, we undertook this research to further extend current knowledge of Scopalina chemistry. The investigation of this species led to the discovery of four new compounds: two butenolides sinularone J (1) and sinularone K (2), one phospholipid 1-O-octadecyl-2-pentanoyl-sn-glycero-3-phosphocholine (3) and one lysophospholipid 1-O-(3-methoxy-tetradecanoyl)-sn-glycero-3-phosphocholine (4) alongside with known lysophospholipids (5 and 6), alkylglycerols (7\u201310), epidioxysterols (11 and 12) and diketopiperazines (13 and 14). The structure elucidation of the new metabolites (1\u20134) was determined by detailed spectroscopic analysis, including 1D and 2D NMR as well as mass spectrometry. Molecular networking was also explored to complement classical investigation and unravel the chemical classes within this species. GNPS analysis provided further information on potential metabolites with additional bioactive natural compounds predicted.<\/jats:p>","DOI":"10.3390\/md20030186","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T22:53:25Z","timestamp":1646261605000},"page":"186","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["New Metabolites from the Marine Sponge Scopalina hapalia Collected in Mayotte Lagoon"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8953-0328","authenticated-orcid":false,"given":"Charifat","family":"Sa\u00efd Hassane","sequence":"first","affiliation":[{"name":"Laboratoire de Chimie et de Biotechnologie des Produits Naturels, Facult\u00e9 des Sciences et Technologies, Universit\u00e9 de La R\u00e9union, 15 Avenue Ren\u00e9 Cassin, CS 92003, CEDEX 09, 97744 Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3374-2508","authenticated-orcid":false,"given":"Ga\u00ebtan","family":"Herbette","sequence":"additional","affiliation":[{"name":"CNRS, Centrale Marseille, FSCM, Spectropole, Aix Marseille Universit\u00e9, Campus de St J\u00e9r\u00f4me-Service 511, 13397 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnur","family":"Garayev","sequence":"additional","affiliation":[{"name":"CNRS 7263, IRD 237, IMBE, Aix Marseille Universit\u00e9, Avignon Universit\u00e9, 13331 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fathi","family":"Mabrouki","sequence":"additional","affiliation":[{"name":"CNRS 7263, IRD 237, IMBE, Aix Marseille Universit\u00e9, Avignon Universit\u00e9, 13331 Marseille, 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13331 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-2772","authenticated-orcid":false,"given":"Ioannis P.","family":"Trougakos","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4483-6638","authenticated-orcid":false,"given":"Jamal","family":"Ouazzani","sequence":"additional","affiliation":[{"name":"Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Universit\u00e9 Paris-Saclay, 1, Av. de la Terrasse, 91198 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0562-2154","authenticated-orcid":false,"given":"Mireille","family":"Fouillaud","sequence":"additional","affiliation":[{"name":"Laboratoire de Chimie et de 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