{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:49:20Z","timestamp":1772304560463,"version":"3.50.1"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,17]],"date-time":"2022-03-17T00:00:00Z","timestamp":1647475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2020B1111030005"],"award-info":[{"award-number":["2020B1111030005"]}]},{"name":"Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)","award":["GML2019ZD0406"],"award-info":[{"award-number":["GML2019ZD0406"]}]},{"name":"Guangdong Local Innovation Team Program","award":["2019BT02Y262"],"award-info":[{"award-number":["2019BT02Y262"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20101"],"award-info":[{"award-number":["U20A20101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973235"],"award-info":[{"award-number":["81973235"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018617","name":"Liao Ning Revitalization Talents Program","doi-asserted-by":"publisher","award":["XLYC1802037"],"award-info":[{"award-number":["XLYC1802037"]}],"id":[{"id":"10.13039\/501100018617","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Five undescribed butenolides including two pairs of enantiomers, (+)-asperteretal G (1a), (\u2212)-asperteretal G (1b), (+)-asperteretal H (2a), (\u2212)-asperteretal H (2b), asperteretal I (3), and para-hydroxybenzaldehyde derivative, (S)-3-(2,3-dihydroxy-3-methylbutyl)-4-hydroxybenzaldehyde (14), were isolated together with ten previously reported butenolides 4\u201313, from the coral-derived fungus Aspergillus terreus SCSIO41404. Enantiomers 1a\/1b and 2a\/2b were successfully purified by high performance liquid chromatography (HPLC) using a chiral column, and the enantiomers 1a and 1b were new natural products. Structures of the unreported compounds, including the absolute configurations, were elucidated by NMR and MS data, optical rotation, experimental and calculated electronic circular dichroism, induced circular dichroism, and X-ray crystal data. The isolated butenolides were evaluated for antibacterial, cytotoxic, and enzyme inhibitory activities. Compounds 7 and 12 displayed weak antibacterial activity, against Enterococcus faecalis (IC50 = 25 \u03bcg\/mL) and Klebsiella pneumoniae (IC50 = 50 \u03bcg\/mL), respectively, whereas 6 showed weak inhibitory effect on acetylcholinesterase. Nevertheless, most of the butenolides showed inhibition against pancreatic lipase (PL) with an inhibition rate of 21.2\u201373.0% at a concentration of 50 \u03bcg\/mL.<\/jats:p>","DOI":"10.3390\/md20030212","type":"journal-article","created":{"date-parts":[[2022,3,20]],"date-time":"2022-03-20T21:30:14Z","timestamp":1647811814000},"page":"212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Butenolides from the Coral-Derived Fungus Aspergillius terreus SCSIO41404"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-5718","authenticated-orcid":false,"given":"Qingyun","family":"Peng","sequence":"first","affiliation":[{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"},{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihao","family":"Chen","sequence":"additional","affiliation":[{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"},{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuping","family":"Lin","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8417-1784","authenticated-orcid":false,"given":"Jiao","family":"Xiao","sequence":"additional","affiliation":[{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-3108","authenticated-orcid":false,"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"},{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-4869","authenticated-orcid":false,"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China"},{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"602","DOI":"10.2174\/1389557520666200925142514","article-title":"An updated review of secondary metabolites from marine fungi","volume":"21","author":"Shabana","year":"2021","journal-title":"Mini-Rev. 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