{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:58:05Z","timestamp":1792112285733,"version":"4.4.0"},"reference-count":113,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:00:00Z","timestamp":1650585600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This research was funded by the National Research Foundation of Korea (NRF) through Brain Pool Program","award":["Grant No. 2021H1D3A2A01100053"],"award-info":[{"award-number":["Grant No. 2021H1D3A2A01100053"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Fucoxanthin, belonging to the xanthophyll class of carotenoids, is a natural antioxidant pigment of marine algae, including brown macroalgae and diatoms. It represents 10% of the total carotenoids in nature. The plethora of scientific evidence supports the potential benefits of nutraceutical and pharmaceutical uses of fucoxanthin for boosting human health and disease management. Due to its unique chemical structure and action as a single compound with multi-targets of health effects, it has attracted mounting attention from the scientific community, resulting in an escalated number of scientific publications from January 2017 to February 2022. Fucoxanthin has remained the most popular option for anti-cancer and anti-tumor activity, followed by protection against inflammatory, oxidative stress-related, nervous system, obesity, hepatic, diabetic, kidney, cardiac, skin, respiratory and microbial diseases, in a variety of model systems. Despite much pharmacological evidence from in vitro and in vivo findings, fucoxanthin in clinical research is still not satisfactory, because only one clinical study on obesity management was reported in the last five years. Additionally, pharmacokinetics, safety, toxicity, functional stability, and clinical perspective of fucoxanthin are substantially addressed. Nevertheless, fucoxanthin and its derivatives are shown to be safe, non-toxic, and readily available upon administration. This review will provide pharmacological insights into fucoxanthin, underlying the diverse molecular mechanisms of health benefits. However, it requires more activity-oriented translational research in humans before it can be used as a multi-target drug.<\/jats:p>","DOI":"10.3390\/md20050279","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T21:39:45Z","timestamp":1650749985000},"page":"279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["A Systematic Review on Marine Algae-Derived Fucoxanthin: An Update of Pharmacological Insights"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7845-5908","authenticated-orcid":false,"given":"Md.","family":"Mohibbullah","sequence":"first","affiliation":[{"name":"Department of Fishing and Post Harvest Technology, Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh"},{"name":"Seafood Research Center, Silla University, #605, Advanced Seafood Processing Complex, Wonyang-ro, Amnam-dong, Seo-gu, Busan 49277, Korea"},{"name":"Department of Food Biotechnology, Division of Bioindustry, College of Medical and Life Sciences, Silla University, Busan 46958, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Nazmul","family":"Haque","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 38066, Korea"},{"name":"Department of Fisheries Biology and Genetics, Patuakhali Science and Technology University, Patuakhali 8602, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9084-2364","authenticated-orcid":false,"given":"Abdullah Al Mamun","family":"Sohag","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3603-669X","authenticated-orcid":false,"given":"Md. Tahmeed","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5768-4317","authenticated-orcid":false,"given":"Md. Sarwar","family":"Zahan","sequence":"additional","affiliation":[{"name":"ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2911-3255","authenticated-orcid":false,"given":"Md. Jamal","family":"Uddin","sequence":"additional","affiliation":[{"name":"ABEx Bio-Research Center, East Azampur, Dhaka 1230, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6640-4495","authenticated-orcid":false,"given":"Md. Abdul","family":"Hannan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1608-016X","authenticated-orcid":false,"given":"Il Soo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 38066, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-6054","authenticated-orcid":false,"given":"Jae-Suk","family":"Choi","sequence":"additional","affiliation":[{"name":"Seafood Research Center, Silla University, #605, Advanced Seafood Processing Complex, Wonyang-ro, Amnam-dong, Seo-gu, Busan 49277, Korea"},{"name":"Department of Food Biotechnology, Division of Bioindustry, College of Medical and Life Sciences, Silla University, Busan 46958, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Khaw, Y.S., Yusoff, F.M., Tan, H.T., Noor Mazli, N.A.I., Nazarudin, M.F., Shaharuddin, N.A., and Omar, A.R. 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