{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:21:53Z","timestamp":1760232113073,"version":"build-2065373602"},"reference-count":40,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T00:00:00Z","timestamp":1652745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Marine Biodiversity Institute (MABIK) Research Program","award":["2022M00400","20180430","20182MFDS423"],"award-info":[{"award-number":["2022M00400","20180430","20182MFDS423"]}]},{"name":"Ministry of Oceans and Fisheries (MOF)","award":["2022M00400","20180430","20182MFDS423"],"award-info":[{"award-number":["2022M00400","20180430","20182MFDS423"]}]},{"name":"Ministry of Food and Drug Safety","award":["2022M00400","20180430","20182MFDS423"],"award-info":[{"award-number":["2022M00400","20180430","20182MFDS423"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Discovering new drug candidates with high efficacy and few side effects is a major challenge in new drug development. The two evolutionarily related peptides oxytocin (OXT) and arginine vasopressin (AVP) are known to be associated with a variety of physiological and psychological processes via the association of OXT with three types of AVP receptors. Over decades, many synthetic analogs of these peptides have been designed and tested for therapeutic applications; however, only a few studies of their natural analogs have been performed. In this study, we investigated the bioactivity and usefulness of two natural OXT\/AVP analogs that originate from the marine invertebrate Octopus vulgaris, named octopressin (OTP) and cephalotocin (CPT). By measuring the intracellular Ca2+ or cyclic AMP increase in each OXT\/AVP receptor subtype\u2013overexpressing cell, we found that CPT, but not OTP, acts as a selective agonist of human AVP type 1b and 2 receptors. This behavior is reminiscent of desmopressin, the most widely prescribed antidiuretic drug in the world. Similar to the case for desmopressin, a single intravenous tail injection of CPT into Sprague-Dawley rats reduced urine output and increased urinary osmolality. In conclusion, we suggest that CPT has a significant antidiuretic effect and that CPT might be beneficial for treating urological conditions such as nocturia, enuresis, and diabetes insipidus.<\/jats:p>","DOI":"10.3390\/md20050328","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T08:34:29Z","timestamp":1652776469000},"page":"328","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An Octopus-Derived Peptide with Antidiuretic Activity in Rats"],"prefix":"10.3390","volume":"20","author":[{"given":"Ye-Ji","family":"Kim","sequence":"first","affiliation":[{"name":"Research Center for Convergence Toxicology, Korea Institute of Toxicology, Daejeon 34114, Korea"},{"name":"Human and Environmental Toxicology, University of Science and Technology, Daejeon 34114, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jei Ha","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9870-0923","authenticated-orcid":false,"given":"Seung-Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Hoon","family":"Choi","sequence":"additional","affiliation":[{"name":"Research Center for Convergence Toxicology, Korea Institute of Toxicology, Daejeon 34114, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0305-3250","authenticated-orcid":false,"given":"Seonmi","family":"Jo","sequence":"additional","affiliation":[{"name":"Department of Genetic Resources, National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-3831","authenticated-orcid":false,"given":"Dong Ho","family":"Woo","sequence":"additional","affiliation":[{"name":"Research Center for Convergence Toxicology, Korea Institute of Toxicology, Daejeon 34114, Korea"},{"name":"Human and Environmental Toxicology, University of Science and Technology, Daejeon 34114, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1152\/physrev.2001.81.2.629","article-title":"The oxytocin receptor system: Structure, function, and regulation","volume":"81","author":"Gimpl","year":"2001","journal-title":"Physiol. 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