{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:49:52Z","timestamp":1787978992992,"version":"build-2784847793"},"reference-count":30,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Oceans and Fisheries, Korea","award":["Development of functional food products with natural materials derived from marine resources (No. 20170285)"],"award-info":[{"award-number":["Development of functional food products with natural materials derived from marine resources (No. 20170285)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Aquacultured fish are the richest natural source of protein. However, their overproduced biomass is often discarded due to production imbalance, causing considerable losses to the fishery industry. Therefore, it is necessary to utilize surplus fish and add value to overproduced fish. We performed complex enzyme-assisted hydrolysis to determine the correlation between its physical characteristics and anti-hypertensive activity in vitro and in vivo using an SHR model. Protamex-Pepsin assisted hydrolysate from Paralichthys olivaceus (POppH) produced by complex enzyme-assisted hydrolysis contained low-molecular-weight peptides and amino acids with anti-hypertensive activity. POppH regulated blood pressure and serum angiotensin II and angiotensin-I-converting enzyme levels, and histological and ultrasound image analysis revealed substantially reduced thickness and diameter of the carotid aorta in the POppH-administered SHR group. Therefore, we propose to reduce food loss due to overproduction by utilizing the anti-hypertensive activity and physical properties of POppH; the results demonstrate its application as a therapeutic agent.<\/jats:p>","DOI":"10.3390\/md20060346","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T08:41:33Z","timestamp":1653468093000},"page":"346","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Utility of a Hydrolysate from Overproduced Paralichthys olivaceus for Hypertension Treatment: Correlation between Physical Properties and Potent Anti-Hypertensive Activities"],"prefix":"10.3390","volume":"20","author":[{"given":"Hyo-Geun","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Young","family":"Oh","sequence":"additional","affiliation":[{"name":"Food Safety and Processing Research Division, National Institute of Fisheries Science, Busan 46083, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Min","family":"Chung","sequence":"additional","affiliation":[{"name":"Shinwoo Corporation. Ltd. 991, Worasan-ro, Munsan-eup, Jinju 52839, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Young","family":"Seo","sequence":"additional","affiliation":[{"name":"Shinwoo Corporation. Ltd. 991, Worasan-ro, Munsan-eup, Jinju 52839, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Jae","family":"Park","sequence":"additional","affiliation":[{"name":"Shinwoo Corporation. Ltd. 991, Worasan-ro, Munsan-eup, Jinju 52839, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3299-7266","authenticated-orcid":false,"given":"You-Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-500X","authenticated-orcid":false,"given":"Bo-Mi","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju 63243, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"ref_1","first-page":"115","article-title":"Analysis on the influencing factors of consumers\u2019 wasting food behaviors: Based on the theory of planned behaviors","volume":"41","author":"Liao","year":"2020","journal-title":"Res. 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