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Drugs"],"abstract":"<jats:p>In the last decades, the interest in seaweed has significantly increased. Bioactive compounds from seaweed\u2019s currently receive major attention from pharmaceutical companies as they express several interesting biological activities which are beneficial for humans. The structural diversity of seaweed metabolites provides diverse biological activities which are expressed through diverse mechanisms of actions. This review mainly focuses on the antiviral activity of seaweed\u2019s extracts, highlighting the mechanisms of actions of some seaweed molecules against infection caused by different types of enveloped viruses: influenza, Lentivirus (HIV-1), Herpes viruses, and coronaviruses. Seaweed metabolites with antiviral properties can act trough different pathways by increasing the host\u2019s defense system or through targeting and blocking virus replication before it enters host cells. Several studies have already established the large antiviral spectrum of seaweed\u2019s bioactive compounds. Throughout this review, antiviral mechanisms and medical applications of seaweed\u2019s bioactive compounds are analyzed, suggesting seaweed\u2019s potential source of antiviral compounds for the formulation of novel and natural antiviral drugs.<\/jats:p>","DOI":"10.3390\/md20060385","type":"journal-article","created":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T10:25:12Z","timestamp":1654856712000},"page":"385","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Antiviral Activity and Mechanisms of Seaweeds Bioactive Compounds on Enveloped Viruses\u2014A Review"],"prefix":"10.3390","volume":"20","author":[{"given":"Silvia","family":"Lomartire","sequence":"first","affiliation":[{"name":"University of Coimbra, Faculty of Sciences and Technology, MARE-Marine and Environmental Sciences Centre, Department of Life Sciences, Cal\u00e7ada Martim de Freitas, 3000-456 Coimbra, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8611-7183","authenticated-orcid":false,"given":"Ana M. 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