{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:58:35Z","timestamp":1789394315039,"version":"build-2803163510"},"reference-count":40,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The \u201cblue shark\u201d, Prionace glauca (class: Chondrichthyes), is a pelagic shark species commonly found in tropical and temperate oceans. This shark is mainly sold in Asian countries as food and as traditional Chinese medicine. According to the Red List of the International Union for the Conservation of Nature, P. glauca is classified as low-risk to near endangered. P. glauca cartilage contains collagen type II, which makes it suitable as a bioactive ingredient in cosmeceutical products. This study evaluated the effects of a gel containing various concentrations (0.125\u20135%) of lyophilized hydrolyzed P. glauca cartilage on the human inner wrist skin compared to a placebo (base). A skin properties evaluation test was conducted before and after applying various concentrations (0.125\u20135%) of the P. glauca cartilage gel for 10 and 20 min on the inner wrists of participants using a skin analyzer that determined the moisture level, oil level, texture level, complexion level, and the 3D level. Adding lyophilized hydrolyzed shark cartilage (LHSC) significantly improved the moisture, texture, and complexion of the skin while controlling oil and providing a wrinkle-smoothing effect. The result indicated that LHSC formulations were prepared at different concentrations, and they had significantly enhanced effects on skin hydration and elasticity (texture) and the smoothing of wrinkles (3D level). The LHSC also effectively controlled oil secretion and the complexion.<\/jats:p>","DOI":"10.3390\/md20100633","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T01:43:11Z","timestamp":1665279791000},"page":"633","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["An In Vivo Study to Evaluate the Efficacy of Blue Shark (Prionace glauca) Cartilage Collagen as a Cosmetic"],"prefix":"10.3390","volume":"20","author":[{"given":"Wen-Chien","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Food and Beverage Management, Chung-Jen Junior College of Nursing, Health Sciences and Management, Chia-Yi City 60077, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Shan","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Taichung Veterans General Hospital, Taichung 40705, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung-Jia","family":"Chan","sequence":"additional","affiliation":[{"name":"College of Biotechnology and Bioresources, Da-Yeh University, Changhua 51591, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Pin","family":"Guo","sequence":"additional","affiliation":[{"name":"Pang-Ho Trading Co., Ltd., Tainan City 700020, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Chin","family":"Lin","sequence":"additional","affiliation":[{"name":"Wisdom International Pet Science Co., Ltd., Chiayi City 600051, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Pang-Ho Trading Co., Ltd., Tainan City 700020, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Pang-Ho Trading Co., Ltd., Tainan City 700020, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda Tresiliana","family":"Mulio","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Providence University, Taichung City 43301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Hsien","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Providence University, Taichung City 43301, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4768","DOI":"10.1002\/ece3.2987","article-title":"World without borders\u2014Genetic population structure of a highly migratory marine predator, the blue shark (Prionace glauca)","volume":"7","author":"Sampaio","year":"2017","journal-title":"Ecol. 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