{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T03:40:01Z","timestamp":1784000401108,"version":"3.55.0"},"reference-count":121,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"VII Program of Inner Initiative for Research and Transfer of the University of Seville","award":["VIIPPIT-2022-III.2"],"award-info":[{"award-number":["VIIPPIT-2022-III.2"]}]},{"name":"VII Program of Inner Initiative for Research and Transfer of the University of Seville","award":["DOC_00587\/2020"],"award-info":[{"award-number":["DOC_00587\/2020"]}]},{"name":"a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University","award":["VIIPPIT-2022-III.2"],"award-info":[{"award-number":["VIIPPIT-2022-III.2"]}]},{"name":"a postdoctoral fellowship from the Andalusian Government Ministry of Economy, Knowledge, Business, and University","award":["DOC_00587\/2020"],"award-info":[{"award-number":["DOC_00587\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Cancer affects more than 19 million people and is the second leading cause of death in the world. One of the principal strategies used in cancer therapy is the inhibition of topoisomerase II, involved in the survival of cells. Side effects and adverse reactions limit the use of topoisomerase II inhibitors; hence, research is focused on discovering novel compounds that can inhibit topoisomerase II and have a safer toxicological profile. Marine organisms are a source of secondary metabolites with different pharmacological properties including anticancer activity. The objective of this review is to present and discuss the pharmacological potential of marine-derived compounds whose antitumor activity is mediated by topoisomerase II inhibition. Several compounds derived from sponges, fungi, bacteria, ascidians, and other marine sources have been demonstrated to inhibit topoisomerase II. However, some studies only report docking interactions, whereas others do not fully explain the mechanisms of topoisomerase II inhibition. Further in vitro and in vivo studies are needed, as well as a careful toxicological profile evaluation with a focus on cancer cell selectivity.<\/jats:p>","DOI":"10.3390\/md20110674","type":"journal-article","created":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T22:36:17Z","timestamp":1666910177000},"page":"674","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Marine-Derived Compounds Targeting Topoisomerase II in Cancer Cells: A Review"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-9977","authenticated-orcid":false,"given":"Giulia","family":"Greco","sequence":"first","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Pellicioni","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6547-8078","authenticated-orcid":false,"given":"Ivan","family":"Cruz-Chamorro","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"},{"name":"Departamento de Bioqu\u00edmica M\u00e9dica y Biolog\u00eda Molecular e Inmunolog\u00eda, Universidad de Sevilla, 41009 Seville, Spain"},{"name":"Instituto de Biomedicina de Sevilla, IBiS (Universidad de Sevilla, HUVR, Junta de Andaluc\u00eda, CSIC), 41013 Seville, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6939-3330","authenticated-orcid":false,"given":"Giuseppe","family":"Attisani","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Stefanelli","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2461-8214","authenticated-orcid":false,"given":"Carmela","family":"Fimognari","sequence":"additional","affiliation":[{"name":"Department for Life Quality Studies, University of Bologna, Corso d\u2019Augusto 237, 47921 Rimini, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"ref_1","unstructured":"(2022, September 13). 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