{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:50:48Z","timestamp":1787500248489,"version":"build-2736575974"},"reference-count":51,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T00:00:00Z","timestamp":1667520000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004242","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2022R166"],"award-info":[{"award-number":["PNURSP2022R166"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004242","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["172116086-SFB 926"],"award-info":[{"award-number":["172116086-SFB 926"]}],"id":[{"id":"10.13039\/501100004242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["PNURSP2022R166"],"award-info":[{"award-number":["PNURSP2022R166"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Princess Nourah bint Abdulrahman University","doi-asserted-by":"publisher","award":["172116086-SFB 926"],"award-info":[{"award-number":["172116086-SFB 926"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>A potential fucoidan-based PEGylated PLGA nanoparticles (NPs) offering a proper delivery of N-methyl anthranilic acid (MA, a model of hydrophobic anti-inflammatory drug) have been developed via the formation of fucoidan aqueous coating surrounding PEGylated PLGA NPs. The optimum formulation (FuP2) composed of fucoidan:m-PEG-PLGA (1:0.5 w\/w) with particle size (365 \u00b1 20.76 nm), zeta potential (\u221222.30 \u00b1 2.56 mV), % entrapment efficiency (85.45 \u00b1 7.41), drug loading (51.36 \u00b1 4.75 \u00b5g\/mg of NPs), % initial burst (47.91 \u00b1 5.89), and % cumulative release (102.79 \u00b1 6.89) has been further investigated for the anti-inflammatory in vivo study. This effect of FuP2 was assessed in rats\u2019 carrageenan-induced acute inflammation model. The average weight of the paw edema was significantly lowered (p \u2264 0.05) by treatment with FuP2. Moreover, cyclooxygenase-2 and tumor necrosis factor-alpha immunostaining were decreased in FuP2 treated group compared to the other groups. The levels of prostaglandin E2, nitric oxide, and malondialdehyde were significantly reduced (p \u2264 0.05) in the FuP2-treated group. A significant reduction (p \u2264 0.05) in the expression of interleukins (IL-1\u03b2 and IL-6) with an improvement of the histological findings of the paw tissues was observed in the FuP2-treated group. Thus, fucoidan-based PEGylated PLGA\u2013MA NPs are a promising anti-inflammatory delivery system that can be applied for other similar drugs potentiating their pharmacological and pharmacokinetic properties.<\/jats:p>","DOI":"10.3390\/md20110694","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T04:00:51Z","timestamp":1667534451000},"page":"694","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Insight into Fucoidan-Based PEGylated PLGA Nanoparticles Encapsulating Methyl Anthranilic Acid: In Vitro Evaluation and In Vivo Anti-Inflammatory Study"],"prefix":"10.3390","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6277-3565","authenticated-orcid":false,"given":"Dalia","family":"Abdelkader","sequence":"first","affiliation":[{"name":"Pharmaceutical Technology Department, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8287-1026","authenticated-orcid":false,"given":"Engy","family":"Elekhnawy","sequence":"additional","affiliation":[{"name":"Pharmaceutical Microbiology Department, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0463-8047","authenticated-orcid":false,"given":"Walaa","family":"Negm","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thanaa","family":"El-Masry","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6732-7591","authenticated-orcid":false,"given":"May","family":"Almukainzi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Science, College Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-6972","authenticated-orcid":false,"given":"Ahmed","family":"Zayed","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt"},{"name":"Institute of Bioprocess Engineering, Technical University of Kaiserslautern, Gottlieb-Daimler-Stra\u00dfe 49, 67663 Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Ulber","sequence":"additional","affiliation":[{"name":"Institute of Bioprocess Engineering, Technical University of Kaiserslautern, Gottlieb-Daimler-Stra\u00dfe 49, 67663 Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s11101-020-09694-5","article-title":"Natural compounds with dual antimicrobial and anti-inflammatory effects","volume":"19","year":"2020","journal-title":"Phytochem. 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