{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:17:00Z","timestamp":1774462620532,"version":"3.50.1"},"reference-count":68,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["41906106"],"award-info":[{"award-number":["41906106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2021A1515011416"],"award-info":[{"award-number":["2021A1515011416"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GDNRC (2021)054"],"award-info":[{"award-number":["GDNRC (2021)054"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["41906106"],"award-info":[{"award-number":["41906106"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["2021A1515011416"],"award-info":[{"award-number":["2021A1515011416"]}]},{"name":"Natural Science Foundation of Guangdong Province, China","award":["GDNRC (2021)054"],"award-info":[{"award-number":["GDNRC (2021)054"]}]},{"name":"Guangdong Provincial Special Fund for Marine Economic Development Project","award":["41906106"],"award-info":[{"award-number":["41906106"]}]},{"name":"Guangdong Provincial Special Fund for Marine Economic Development Project","award":["2021A1515011416"],"award-info":[{"award-number":["2021A1515011416"]}]},{"name":"Guangdong Provincial Special Fund for Marine Economic Development Project","award":["GDNRC (2021)054"],"award-info":[{"award-number":["GDNRC (2021)054"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Organosulfur natural products (NPs) refer to the different kinds of small molecular-containing sulfur (S) elements. Sulfur-containing NPs tightly link to the biochemical processes and play an important role in the pharmaceutical industry. The majority of S-containing NPs are generally isolated from Alliaceae plants or bacteria, and those from fungi are still relatively rare. In recent years, an increasing number of S-containing metabolites have been discovered in marine and terrestrial fungi, but there is no comprehensive and targeted review to summarize the studies. In order to make it more straightforward to better grasp the fungal-derived S-containing NPs and understand the particularity of marine S-containing NPs compared to those from terrestrial fungi, we summarized the chemical structures and biological activities of 89 new fungal-derived S-containing metabolites from 1929 when the penicillin was discovered to the present in this current review. The structural and bioactive diversity of these S-containing metabolites were concluded in detail, and the preliminary mechanism for C-S bond formation in fungi was also discussed briefly.<\/jats:p>","DOI":"10.3390\/md20120765","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T04:00:37Z","timestamp":1670385637000},"page":"765","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Sulfur-Containing Metabolites from Marine and Terrestrial Fungal Sources: Origin, Structures, and Bioactivities"],"prefix":"10.3390","volume":"20","author":[{"given":"Zhaoming","family":"Liu","sequence":"first","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqiong","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibin","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8945-9448","authenticated-orcid":false,"given":"Weimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, 100 Central Xianlie Road, Yuexiu District, Guangzhou 510070, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1093\/jn\/136.6.1636S","article-title":"The sulfur-containing amino acid: An overview","volume":"136","author":"Brosnan","year":"2006","journal-title":"J. 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