{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:34:26Z","timestamp":1788572066081,"version":"build-2803163510"},"reference-count":54,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Peptic ulcer is a widespread disease, with a lifetime frequency of 5\u201310% among the general population and an annual incidence of 0.1\u20130.3%. Ovothiol A is naturally produced from sea urchin eggs with special antioxidant activity. Gastric ulcers were induced in rats by a single ethanol dose (5 mL\/kg). The rats were divided into control, ulcer, and ulcer with 250 and 500 mg\/kg ovothiol A doses. Molecular docking studies were used to examine the interactions between ovothiol A and the H+\/K+ ATPase active site residues. Ovothiol A led to a significant decline (p &lt; 0.05) in gastric juice volume, ulcer index, MDA, IL-6, and cytochrome c, while levels of gastric juice pH, GSH, CAT, GST, SOD, and NO increased. Histopathological investigation of stomach sections revealed architecture preservation of the gastric mucosa after ovothiol A administration. The anti-ulcerogenic activity of ovothiol A includes scavenging free radicals, inhibition of inflammation, regulation of apoptosis, and stabilization of fibroblast growth factors to promote gastric ulcers healing.<\/jats:p>","DOI":"10.3390\/md21010025","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T02:54:42Z","timestamp":1672282482000},"page":"25","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Therapeutic Potency of Ovothiol A on Ethanol-Induced Gastric Ulcers in Wistar Rats"],"prefix":"10.3390","volume":"21","author":[{"given":"Amira Tarek","family":"Salaheldin","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Faculty of Sciences, Cairo University, Giza 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-0285","authenticated-orcid":false,"given":"Mohamed Refaat","family":"Shehata","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Sciences, Cairo University, Giza 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2917-2423","authenticated-orcid":false,"given":"Hader I.","family":"Sakr","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Faculty of Medicine, Cairo University, Giza 12613, Egypt"},{"name":"Department of Medical Physiology, Medicine Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek","family":"Atia","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 16273, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman Saber","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science, Cairo University, Giza 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Kuna, L., Jakab, J., Smolic, R., Raguz-Lucic, N., Vcev, A., and Smolic, M. 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