{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:13:12Z","timestamp":1790957592341,"version":"4.1.0"},"reference-count":64,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["JPMJCR2024"],"award-info":[{"award-number":["JPMJCR2024"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["JP21H05269"],"award-info":[{"award-number":["JP21H05269"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["JP22K19395"],"award-info":[{"award-number":["JP22K19395"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["JP22H02772"],"award-info":[{"award-number":["JP22H02772"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["18H05277"],"award-info":[{"award-number":["18H05277"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["21H05258"],"award-info":[{"award-number":["21H05258"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["21H05263"],"award-info":[{"award-number":["21H05263"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["22K19397"],"award-info":[{"award-number":["22K19397"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["JP21mk0101189"],"award-info":[{"award-number":["JP21mk0101189"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["JP22ama121031"],"award-info":[{"award-number":["JP22ama121031"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"JST CREST","doi-asserted-by":"publisher","award":["1711173698"],"award-info":[{"award-number":["1711173698"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"name":"JSPS KAKENHI","award":["JPMJCR2024"],"award-info":[{"award-number":["JPMJCR2024"]}]},{"name":"JSPS KAKENHI","award":["JP21H05269"],"award-info":[{"award-number":["JP21H05269"]}]},{"name":"JSPS KAKENHI","award":["JP22K19395"],"award-info":[{"award-number":["JP22K19395"]}]},{"name":"JSPS KAKENHI","award":["JP22H02772"],"award-info":[{"award-number":["JP22H02772"]}]},{"name":"JSPS KAKENHI","award":["18H05277"],"award-info":[{"award-number":["18H05277"]}]},{"name":"JSPS KAKENHI","award":["21H05258"],"award-info":[{"award-number":["21H05258"]}]},{"name":"JSPS KAKENHI","award":["21H05263"],"award-info":[{"award-number":["21H05263"]}]},{"name":"JSPS KAKENHI","award":["22K19397"],"award-info":[{"award-number":["22K19397"]}]},{"name":"JSPS KAKENHI","award":["JP21mk0101189"],"award-info":[{"award-number":["JP21mk0101189"]}]},{"name":"JSPS KAKENHI","award":["JP22ama121031"],"award-info":[{"award-number":["JP22ama121031"]}]},{"name":"JSPS KAKENHI","award":["1711173698"],"award-info":[{"award-number":["1711173698"]}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JPMJCR2024"],"award-info":[{"award-number":["JPMJCR2024"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP21H05269"],"award-info":[{"award-number":["JP21H05269"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP22K19395"],"award-info":[{"award-number":["JP22K19395"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP22H02772"],"award-info":[{"award-number":["JP22H02772"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["18H05277"],"award-info":[{"award-number":["18H05277"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["21H05258"],"award-info":[{"award-number":["21H05258"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["21H05263"],"award-info":[{"award-number":["21H05263"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["22K19397"],"award-info":[{"award-number":["22K19397"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP21mk0101189"],"award-info":[{"award-number":["JP21mk0101189"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["JP22ama121031"],"award-info":[{"award-number":["JP22ama121031"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["1711173698"],"award-info":[{"award-number":["1711173698"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Commercializations Promotion Agency","award":["JPMJCR2024"],"award-info":[{"award-number":["JPMJCR2024"]}]},{"name":"Commercializations Promotion Agency","award":["JP21H05269"],"award-info":[{"award-number":["JP21H05269"]}]},{"name":"Commercializations Promotion Agency","award":["JP22K19395"],"award-info":[{"award-number":["JP22K19395"]}]},{"name":"Commercializations Promotion Agency","award":["JP22H02772"],"award-info":[{"award-number":["JP22H02772"]}]},{"name":"Commercializations Promotion Agency","award":["18H05277"],"award-info":[{"award-number":["18H05277"]}]},{"name":"Commercializations Promotion Agency","award":["21H05258"],"award-info":[{"award-number":["21H05258"]}]},{"name":"Commercializations Promotion Agency","award":["21H05263"],"award-info":[{"award-number":["21H05263"]}]},{"name":"Commercializations Promotion Agency","award":["22K19397"],"award-info":[{"award-number":["22K19397"]}]},{"name":"Commercializations Promotion Agency","award":["JP21mk0101189"],"award-info":[{"award-number":["JP21mk0101189"]}]},{"name":"Commercializations Promotion Agency","award":["JP22ama121031"],"award-info":[{"award-number":["JP22ama121031"]}]},{"name":"Commercializations Promotion Agency","award":["1711173698"],"award-info":[{"award-number":["1711173698"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Abnormal sulfide catabolism, especially the accumulation of hydrogen sulfide (H2S) during hypoxic or inflammatory stresses, is a major cause of redox imbalance-associated cardiac dysfunction. Polyhydroxynaphtoquinone echinochrome A (Ech-A), a natural pigment of marine origin found in the shells and needles of many species of sea urchins, is a potent antioxidant and inhibits acute myocardial ferroptosis after ischemia\/reperfusion, but the chronic effect of Ech-A on heart failure is unknown. Reactive sulfur species (RSS), which include catenated sulfur atoms, have been revealed as true biomolecules with high redox reactivity required for intracellular energy metabolism and signal transduction. Here, we report that continuous intraperitoneal administration of Ech-A (2.0 mg\/kg\/day) prevents RSS catabolism-associated chronic heart failure after myocardial infarction (MI) in mice. Ech-A prevented left ventricular (LV) systolic dysfunction and structural remodeling after MI. Fluorescence imaging revealed that intracellular RSS level was reduced after MI, while H2S\/HS\u2212 level was increased in LV myocardium, which was attenuated by Ech-A. This result indicates that Ech-A suppresses RSS catabolism to H2S\/HS\u2212 in LV myocardium after MI. In addition, Ech-A reduced oxidative stress formation by MI. Ech-A suppressed RSS catabolism caused by hypoxia in neonatal rat cardiomyocytes and human iPS cell-derived cardiomyocytes. Ech-A also suppressed RSS catabolism caused by lipopolysaccharide stimulation in macrophages. Thus, Ech-A has the potential to improve chronic heart failure after MI, in part by preventing sulfide catabolism.<\/jats:p>","DOI":"10.3390\/md21010052","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T02:29:57Z","timestamp":1673576997000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Echinochrome Prevents Sulfide Catabolism-Associated Chronic Heart Failure after Myocardial Infarction in Mice"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-4636","authenticated-orcid":false,"given":"Xiaokang","family":"Tang","sequence":"first","affiliation":[{"name":"Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Department of Physiological Sciences, SOKENDAI (School of Life Science, The Graduate University for Advanced Studies), Okazaki 444-8787, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2309-3994","authenticated-orcid":false,"given":"Akiyuki","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Department of Physiological Sciences, SOKENDAI (School of Life Science, The Graduate University for Advanced Studies), Okazaki 444-8787, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Ariyoshi","sequence":"additional","affiliation":[{"name":"Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6263-3562","authenticated-orcid":false,"given":"Kazuhiro","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9426-911X","authenticated-orcid":false,"given":"Yuri","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7526-026X","authenticated-orcid":false,"given":"Elena","family":"Vasileva","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7616-574X","authenticated-orcid":false,"given":"Natalia","family":"Mishchenko","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4199-2099","authenticated-orcid":false,"given":"Sergey","family":"Fedoreyev","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Stonik","sequence":"additional","affiliation":[{"name":"G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-Eastern Branch of the Russian Academy of Science, Vladivostok 690022, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1791-7865","authenticated-orcid":false,"given":"Hyoung-Kyu","family":"Kim","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disease Center (CMDC), Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1859-3425","authenticated-orcid":false,"given":"Jin","family":"Han","sequence":"additional","affiliation":[{"name":"Cardiovascular and Metabolic Disease Center (CMDC), Inje University, Busan 47392, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2527-3526","authenticated-orcid":false,"given":"Yasunari","family":"Kanda","sequence":"additional","affiliation":[{"name":"Division of Pharmacology, National Institute of Health Sciences, Kawasaki 210-9501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2380-4453","authenticated-orcid":false,"given":"Keitaro","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Research Team for Mechanism of Aging, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuteru","family":"Urano","sequence":"additional","affiliation":[{"name":"Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan"},{"name":"Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0623-1710","authenticated-orcid":false,"given":"Takaaki","family":"Akaike","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2587-5458","authenticated-orcid":false,"given":"Motohiro","family":"Nishida","sequence":"additional","affiliation":[{"name":"Division of Cardiocirculatory Signaling, National Institute for Physiological Sciences (NIPS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, Okazaki 444-8787, Japan"},{"name":"Department of Physiological Sciences, SOKENDAI (School of Life Science, The Graduate University for Advanced Studies), Okazaki 444-8787, Japan"},{"name":"Department of Physiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e005375","DOI":"10.1161\/CIRCOUTCOMES.118.005375","article-title":"Mortality from ischemic heart disease: Analysis of data from the world health organization and coronary artery disease risk factors from NCD risk factor collaboration","volume":"12","author":"Nowbar","year":"2019","journal-title":"Circ. Cardiovasc. Qual. Outcomes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/eurheartj\/ehy462","article-title":"Fourth universal definition of myocardial infarction (2018)","volume":"40","author":"Thygesen","year":"2019","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1161\/CIRCRESAHA.113.300987","article-title":"Historical Perspective on the Pathology of Myocardial Ischemia\/Reperfusion Injury","volume":"113","author":"Jennings","year":"2013","journal-title":"Circ. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1161\/01.CIR.53.2.293","article-title":"Influence of acute changes in preload, afterload, contractile state and heart rate on ejection and isovolumic indices of myocardial contractility in man","volume":"53","author":"Quinones","year":"1976","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1161\/01.CIR.0000070420.51787.A8","article-title":"Left Ventricular Remodeling and Ventricular Arrhythmias After Myocardial Infarction","volume":"107","author":"Sutton","year":"2003","journal-title":"Circulation"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s41467-017-01311-y","article-title":"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics","volume":"8","author":"Akaike","year":"2017","journal-title":"Nat. Commun."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1021\/ja01492a058","article-title":"Reactivity of Nucleophilic Reagents toward Esters","volume":"82","author":"Jencks","year":"1960","journal-title":"J. Am. Chem. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1021\/ja00860a005","article-title":"The Factors Determining Nucleophilic Reactivities","volume":"84","author":"Edwards","year":"1962","journal-title":"J. Am. Chem. Soc."},{"key":"ref_9","first-page":"139","article-title":"Biogenesis of reactive sulfur species for signaling by hydrogen sulfide oxidation pathways","volume":"176","author":"Khalil","year":"2016","journal-title":"Physiol. Behav."},{"key":"ref_10","first-page":"237","article-title":"Chemical Foundations of Hydrogen Sulfide Biology","volume":"23","author":"Ebert","year":"2013","journal-title":"Bone"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"eaaw1920","DOI":"10.1126\/scisignal.aaw1920","article-title":"Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload","volume":"12","author":"Nishimura","year":"2019","journal-title":"Sci. Signal."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","article-title":"The possible role of hydrogen sulfide as an endogenous neuromodulator","volume":"16","author":"Abe","year":"1996","journal-title":"J. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrm3391","article-title":"H2S signalling through protein sulfhydration and beyond","volume":"13","author":"Paul","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"52082","DOI":"10.1074\/jbc.C400481200","article-title":"Production of the Neuromodulator H2S by Cystathionine \u03b2-Synthase via the Condensation of Cysteine and Homocysteine","volume":"279","author":"Chen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1038\/s41467-021-23363-x","article-title":"Sulfide catabolism ameliorates hypoxic brain injury","volume":"12","author":"Marutani","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s11101-018-9547-3","article-title":"Naphthoquinone pigments from sea urchins: Chemistry and pharmacology","volume":"17","author":"Shikov","year":"2018","journal-title":"Phytochem. Rev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s10337-013-2427-5","article-title":"Evaluation of Free Radical-Scavenging Activity of Sea Urchin Pigments Using HPTLC with Post-Chromatographic Derivatization","volume":"76","author":"Pozharitskaya","year":"2013","journal-title":"Chromatographia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"111933","DOI":"10.1016\/j.jep.2019.111933","article-title":"Animal-derived medicinal products in Russia: Current nomenclature and specific aspects of quality control","volume":"240","author":"Prokopov","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kim, H., Vasileva, E., Mishchenko, N., Fedoreyev, S., and Han, J. (2021). Multifaceted Clinical Effects of Echinochrome. Mar. Drugs, 19.","DOI":"10.3390\/md19080412"},{"key":"ref_21","first-page":"12","article-title":"Effect of the bioantioxidant histochrome on myocardial injury in reperfusion therapy on patients with myocardial infarction","volume":"74","author":"Maksimov","year":"2002","journal-title":"Ter. arkhiv"},{"key":"ref_22","first-page":"21","article-title":"Pharmacokinetics and clinical efficacy of histochrome in patients with acute myocardial infarction","volume":"60","author":"Zakirova","year":"1997","journal-title":"Eksp. Klin. Farmakol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1007\/BF02445124","article-title":"ATP-sparing effect of histochrome in acute myocardial ischemia in patients with coronary heart disease","volume":"124","author":"Lasukova","year":"1997","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Hwang, J.-W., Park, J.-H., Park, B.-W., Kim, H., Kim, J.-J., Sim, W.-S., Mishchenko, N.P., Fedoreyev, S.A., Vasileva, E.A., and Ban, K. (2021). Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death. Antioxidants, 10.","DOI":"10.3390\/antiox10101624"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Kim, R., Hur, D., Kim, H.K., Han, J., Mishchenko, N.P., Fedoreyev, S.A., Stonik, V.A., and Chang, W. (2019). Echinochrome a Attenuates Cerebral Ischemic Injury through Regulation of Cell Survival after Middle Cerebral Artery Occlusion in Rat. Mar. Drugs, 17.","DOI":"10.3390\/md17090501"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10517-005-0469-x","article-title":"Effect of Natural Antioxidants on Antioxidant Activity and Lipid Peroxidation in Eye Tissue of Rabbits with Chemical Burns","volume":"140","author":"Gakhramanov","year":"2005","journal-title":"Bull. Exp. Biol. Med."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Yun, H.R., Ahn, S.W., Seol, B., Vasileva, E.A., Mishchenko, N.P., Fedoreyev, S.A., Stonik, V.A., Han, J., Ko, K.S., and Rhee, B.D. (2021). Echinochrome A Treatment Alleviates Atopic Dermatitis-like Skin Lesions in NC\/Nga Mice via IL-4 and IL-13 Suppression. Mar. Drugs, 19.","DOI":"10.3390\/md19110622"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Park, G.-T., Yoon, J.-W., Yoo, S.-B., Song, Y.-C., Song, P., Kim, H.-K., Han, J., Bae, S.-J., Ha, K.-T., and Mishchenko, N. (2021). Echinochrome A Treatment Alleviates Fibrosis and Inflammation in Bleomycin-Induced Scleroderma. Mar. Drugs, 19.","DOI":"10.3390\/md19050237"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.3390\/md12052922","article-title":"Echinochrome A Protects Mitochondrial Function in Cardiomyocytes against Cardiotoxic Drugs","volume":"12","author":"Jeong","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/01.CIR.101.25.2981","article-title":"Left Ventricular Remodeling After Myocardial Infarction: Pathophysiology and therapy","volume":"101","author":"Sutton","year":"2000","journal-title":"Circulation"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.psychres.2018.09.046","article-title":"Longitudinal associations between 4-hydroxynonenal and depression in coronary artery disease patients","volume":"270","author":"Rosen","year":"2018","journal-title":"Psychiatry Res."},{"key":"ref_32","first-page":"139","article-title":"Polymeric persulfide prodrugs: Mitigating oxidative stress through controlled delivery of reactive sulfur species","volume":"176","author":"Dillon","year":"2017","journal-title":"Physiol. Behav."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"srep41984","DOI":"10.1038\/srep41984","article-title":"Metabolomic profiling of reactive persulfides and polysulfides in the aqueous and vitreous humors","volume":"7","author":"Kunikata","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1039\/C6CC08372B","article-title":"Development of a reversible fluorescent probe for reactive sulfur species, sulfane sulfur, and its biological application","volume":"53","author":"Takano","year":"2017","journal-title":"Chem. Commun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7131","DOI":"10.1073\/pnas.1302193110","article-title":"Cell-trappable fluorescent probes for endogenous hydrogen sulfide signaling and imaging H2O2-dependent H2S production","volume":"110","author":"Lin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"9346","DOI":"10.1002\/anie.201804309","article-title":"A Reversible Fluorescent Probe for Real-Time Live-Cell Imaging and Quantification of Endogenous Hydropolysulfides","volume":"57","author":"Umezawa","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1007\/s10753-021-01467-2","article-title":"New Insights and Novel Therapeutic Potentials for Macrophages in Myocardial Infarction","volume":"44","author":"Zhang","year":"2021","journal-title":"Inflammation"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1161\/CIRCRESAHA.119.312321","article-title":"Obesity, hypertension, and cardiac dysfunction novel roles of immunometabolism in macrophage activation and inflammation","volume":"126","author":"Mouton","year":"2020","journal-title":"Circ. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s00109-012-0963-3","article-title":"NADPH oxidases as a source of oxidative stress and molecular target in ischemia\/reperfusion injury","volume":"90","author":"Kleikers","year":"2012","journal-title":"J. Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"174368","DOI":"10.1016\/j.ejphar.2021.174368","article-title":"Allopurinol attenuates oxidative injury in rat hearts suffered ischemia\/reperfusion via suppressing the xanthine oxidase\/vascular peroxidase 1 pathway","volume":"908","author":"Zhang","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1161\/CIRCULATIONAHA.111.041814","article-title":"Impaired Autophagosome Clearance Contributes to Cardiomyocyte Death in Ischemia\/Reperfusion Injury","volume":"125","author":"Ma","year":"2012","journal-title":"Circulation"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/01.RES.88.5.529","article-title":"Mitochondrial DNA Damage and Dysfunction Associated With Oxidative Stress in Failing Hearts After Myocardial Infarction","volume":"88","author":"Ide","year":"2001","journal-title":"Circ. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.biopha.2018.07.173","article-title":"Echinochrome pigment as novel therapeutic agent against experimentally\u2014Induced gastric ulcer in rats","volume":"107","author":"Sayed","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jss.2018.10.004","article-title":"Hepatoprotective Effect of Echinochrome Pigment in Septic Rats","volume":"234","author":"Mohamed","year":"2019","journal-title":"J. Surg. Res."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1590\/1519-6984.192697","article-title":"Protective effect of Echinochrome against intrahepatic cholestasis induced by alpha-naphthylisothiocyanate in rats","volume":"80","author":"Fahmy","year":"2020","journal-title":"Braz. J. Biol."},{"key":"ref_47","first-page":"171","article-title":"Amelioration of endotoxin-induced uveitis treated with the sea urchin pigment echinochrome in rats","volume":"20","author":"Lennikov","year":"2014","journal-title":"Mol. Vis."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Oh, S.-J., Seo, Y., Ahn, J.-S., Shin, Y.Y., Yang, J.W., Kim, H.K., Han, J., Mishchenko, N.P., Fedoreyev, S.A., and Stonik, V.A. (2019). Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells. Mar. Drugs, 17.","DOI":"10.3390\/md17110622"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Artyukov, A.A., Zelepuga, E.A., Bogdanovich, L.N., Lupach, N.M., Novikov, V.L., Rutckova, T.A., and Kozlovskaya, E.P. (2020). Marine Polyhydroxynaphthoquinone, Echinochrome A: Prevention of Atherosclerotic Inflammation and Probable Molecular Targets. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051494"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3389\/fphys.2017.00525","article-title":"The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency","volume":"8","author":"Quinzii","year":"2017","journal-title":"Front. Physiol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.tox.2004.05.020","article-title":"H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation","volume":"203","author":"Eghbal","year":"2004","journal-title":"Toxicology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s10863-008-9166-6","article-title":"The inhibition of mitochondrial cytochrome oxidase by the gases carbon monoxide, nitric oxide, hydrogen cyanide and hydrogen sulfide: Chemical mechanism and physiological significance","volume":"40","author":"Cooper","year":"2008","journal-title":"J. Bioenerg. Biomembr."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1111\/j.1476-5381.2011.01681.x","article-title":"Sulphide quinone reductase contributes to hydrogen sulphide metabolism in murine peripheral tissues but not in the CNS","volume":"165","author":"Linden","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nchembio.1018","article-title":"Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration","volume":"8","author":"Nishida","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3164\/jcbn.20-13","article-title":"Antioxidative and anti-inflammatory actions of reactive cysteine persulfides","volume":"68","author":"Zhang","year":"2021","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3164\/jcbn.21-84","article-title":"Cardiac robustness regulated by reactive sulfur species","volume":"70","author":"Nishimura","year":"2021","journal-title":"J. Clin. Biochem. Nutr."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"eaat5185","DOI":"10.1126\/scisignal.aat5185","article-title":"Hypoxia-induced interaction of filamin with Drp1 causes mitochondrial hyperfission\u2013associated myocardial senescence","volume":"11","author":"Nishimura","year":"2018","journal-title":"Sci. Signal."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1089\/ars.2007.1825","article-title":"LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species\u2013Dependent Manner","volume":"10","author":"Nishi","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.chembiol.2019.02.003","article-title":"Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Chem. Biol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.mito.2021.06.007","article-title":"Polysulfide inhibits hypoxia-elicited hypoxia-inducible factor activation in a mitochondria-dependent manner","volume":"59","author":"Uba","year":"2021","journal-title":"Mitochondrion"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"e13688","DOI":"10.14814\/phy2.13688","article-title":"A simple antegrade perfusion method for isolating viable single cardiomyocytes from neonatal to aged mice","volume":"6","author":"Yoshioka","year":"2018","journal-title":"Physiol. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.intimp.2017.12.003","article-title":"Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling","volume":"55","author":"Nishiyama","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"8686","DOI":"10.1073\/pnas.0500419102","article-title":"The primary mechanism of the IL-10-regulated antiinflammatory response is to selectively inhibit transcription","volume":"102","author":"Murray","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"eabj0644","DOI":"10.1126\/scisignal.abj0644","article-title":"Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression","volume":"15","author":"Nishiyama","year":"2022","journal-title":"Sci. Signal."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/21\/1\/52\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:04:47Z","timestamp":1760119487000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/21\/1\/52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["md21010052"],"URL":"https:\/\/doi.org\/10.3390\/md21010052","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,12]]}}}