{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:03Z","timestamp":1787028903680,"version":"build-2736575974"},"reference-count":30,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,14]],"date-time":"2023-03-14T00:00:00Z","timestamp":1678752000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["U20A2001"],"award-info":[{"award-number":["U20A2001"]}]},{"name":"the National Natural Science Foundation of China","award":["42276114"],"award-info":[{"award-number":["42276114"]}]},{"name":"the National Natural Science Foundation of China","award":["82104228"],"award-info":[{"award-number":["82104228"]}]},{"name":"the National Natural Science Foundation of China","award":["2020B1111030005"],"award-info":[{"award-number":["2020B1111030005"]}]},{"name":"the National Natural Science Foundation of China","award":["2021GDASYL\u201320210103057"],"award-info":[{"award-number":["2021GDASYL\u201320210103057"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["U20A2001"],"award-info":[{"award-number":["U20A2001"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["42276114"],"award-info":[{"award-number":["42276114"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["82104228"],"award-info":[{"award-number":["82104228"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2020B1111030005"],"award-info":[{"award-number":["2020B1111030005"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2021GDASYL\u201320210103057"],"award-info":[{"award-number":["2021GDASYL\u201320210103057"]}]},{"name":"GDAS Special Project of Science and Technology Development","award":["U20A2001"],"award-info":[{"award-number":["U20A2001"]}]},{"name":"GDAS Special Project of Science and Technology Development","award":["42276114"],"award-info":[{"award-number":["42276114"]}]},{"name":"GDAS Special Project of Science and Technology Development","award":["82104228"],"award-info":[{"award-number":["82104228"]}]},{"name":"GDAS Special Project of Science and Technology Development","award":["2020B1111030005"],"award-info":[{"award-number":["2020B1111030005"]}]},{"name":"GDAS Special Project of Science and Technology Development","award":["2021GDASYL\u201320210103057"],"award-info":[{"award-number":["2021GDASYL\u201320210103057"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Seven new polyketides, including four indenone derivatives, cytoindenones A\u2013C (1, 3\u20134), 3\u2032-methoxycytoindenone A (2), a benzophenone derivative, cytorhizophin J (6), and a pair of tetralone enantiomers, (\u00b1)-4,6-dihydroxy-5-methoxy-\u03b1-tetralone (7), together with a known compound (5) were obtained from the endophytic fungus Cytospora heveae NSHSJ-2 isolated from the fresh stem of the mangrove plant Sonneratia caseolaris. Compound 3 represented the first natural indenone monomer substituted by two benzene moieties at C-2 and C-3. Their structures were determined by the analysis of 1D and 2D NMR, as well as mass spectroscopic data, and the absolute configurations of (\u00b1)-7 were determined on the basis of the observed specific rotation value compared with those of the tetralone derivatives previously reported. In bioactivity assays, compounds 1, 4\u20136 showed potent DPPH\u00b7 scavenging activities, with EC50 values ranging from 9.5 to 16.6 \u00b5M, better than the positive control ascorbic acid (21.9 \u00b5M); compounds 2\u20133 also exhibited DPPH\u00b7 scavenging activities comparable to ascorbic acid.<\/jats:p>","DOI":"10.3390\/md21030181","type":"journal-article","created":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T04:39:45Z","timestamp":1678855185000},"page":"181","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Antioxidative Indenone and Benzophenone Derivatives from the Mangrove-Derived Fungus Cytospora heveae NSHSJ-2"],"prefix":"10.3390","volume":"21","author":[{"given":"Ge","family":"Zou","sequence":"first","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taobo","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wencong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghui","family":"Ou","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Institute of Zoology, Guangdong Academy of Sciences, Guangzhou 510260, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-6701","authenticated-orcid":false,"given":"Zhigang","family":"She","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1002\/slct.202100177","article-title":"Medicinal chemistry of indane and its analogues: A mini review","volume":"6","author":"Prasher","year":"2021","journal-title":"ChemistrySelect"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1016\/j.bmc.2018.06.040","article-title":"Indenone derivatives as inhibitor of human DNA dealkylation repair enzyme AlkBH3","volume":"26","author":"Nigam","year":"2018","journal-title":"Bioorgan. 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