{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:58:10Z","timestamp":1792112290726,"version":"4.4.0"},"reference-count":180,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T00:00:00Z","timestamp":1679356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Cardiovascular diseases (CVDs) are among the most impactful illnesses globally. Currently, the available therapeutic option has several side effects, including hypotension, bradycardia, arrhythmia, and alteration in different ion concentrations. Recently, bioactive compounds from natural sources, including plants, microorganisms, and marine creatures, have gained a lot of interest. Marine sources serve as reservoirs for new bioactive metabolites with various pharmacological activities. The marine-derived compound such as omega-3 acid ethyl esters, xyloketal B, asperlin, and saringosterol showed promising results in several CVDs. The present review focuses on marine-derived compounds\u2019 cardioprotective potential for hypertension, ischemic heart disease, myocardial infarction, and atherosclerosis. In addition to therapeutic alternatives, the current use of marine-derived components, the future trajectory, and restrictions are also reviewed.<\/jats:p>","DOI":"10.3390\/md21030193","type":"journal-article","created":{"date-parts":[[2023,3,21]],"date-time":"2023-03-21T06:56:48Z","timestamp":1679381808000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Marine-Derived Compounds Applied in Cardiovascular Diseases: Submerged Medicinal Industry"],"prefix":"10.3390","volume":"21","author":[{"given":"Wasim","family":"Akram","sequence":"first","affiliation":[{"name":"Department of Pharmacology, SPER, Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0632-9280","authenticated-orcid":false,"given":"Mohd","family":"Rihan","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali 160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakeel","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Mohali 160062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swamita","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, R. V. Northland Institute of Pharmacy, Dadri 203207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9232-5819","authenticated-orcid":false,"given":"Sameer","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Food Technology Jamia Hamdard, New Delhi 110062, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Vashishth","sequence":"additional","affiliation":[{"name":"School of BioSciences and Technology-Food Technology, Vellore Institute of Technology, Vellore 632014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,21]]},"reference":[{"key":"ref_1","first-page":"248","article-title":"Nanomaterials Based Flexible Devices for Monitoring and Treatment of Cardiovascular Diseases (CVDs)","volume":"89","author":"Xiang","year":"2022","journal-title":"Nano Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global Burden of Cardiovascular Diseases and Risk Factors, 1990\u20132019: Update From the GBD 2019 Study","volume":"76","author":"Roth","year":"2020","journal-title":"J. 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