{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:10:49Z","timestamp":1789873849810,"version":"4.0.1"},"reference-count":73,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Genova","award":["CN_00000033"],"award-info":[{"award-number":["CN_00000033"]}]},{"name":"National Recovery and Resilience Plan (NRRP)","award":["CN_00000033"],"award-info":[{"award-number":["CN_00000033"]}]},{"name":"European Union","award":["CN_00000033"],"award-info":[{"award-number":["CN_00000033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>There is a growing interest in using brown algal extracts thanks to the bioactive substances they produce for adaptation to the marine benthic environment. We evaluated the anti-aging and photoprotective properties of two types of extracts (50%-ethanol and DMSO) obtained from different portions, i.e., apices and thalli, of the brown seaweed, Ericaria amentacea. The apices of this alga, which grow and develop reproductive structures during summer when solar radiation is at its peak, were postulated to be rich in antioxidant compounds. We determined the chemical composition and pharmacological effects of their extracts and compared them to the thallus-derived extracts. All the extracts contained polyphenols, flavonoids and antioxidants and showed significant biological activities. The hydroalcoholic apices extracts demonstrated the highest pharmacological potential, likely due to the higher content of meroditerpene molecular species. They blocked toxicity in UV-exposed HaCaT keratinocytes and L929 fibroblasts and abated the oxidative stress and the production of pro-inflammatory cytokines, typically released after sunburns. Furthermore, the extracts showed anti-tyrosinase and anti-hydrolytic skin enzyme activity, counteracting the collagenase and hyaluronidase degrading activities and possibly slowing down the formation of uneven pigmentation and wrinkles in aging skin. In conclusion, the E. amentacea apices derivatives constitute ideal components for counteracting sunburn symptoms and for cosmetic anti-aging lotions.<\/jats:p>","DOI":"10.3390\/md21050306","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T07:03:58Z","timestamp":1684393438000},"page":"306","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Photoprotective and Anti-Aging Properties of the Apical Frond Extracts from the Mediterranean Seaweed Ericaria amentacea"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3395-9579","authenticated-orcid":false,"given":"Serena","family":"Mirata","sequence":"first","affiliation":[{"name":"Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, 16132 Genova, Italy"},{"name":"Centro 3R, Interuniversity Center for the Promotion of the Principles of the 3Rs in Teaching and Research, 56122 Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-2613","authenticated-orcid":false,"given":"Valentina","family":"Asnaghi","sequence":"additional","affiliation":[{"name":"Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy"},{"name":"National Biodiversity Future Center (NBFC), 90133 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariachiara","family":"Chiantore","sequence":"additional","affiliation":[{"name":"Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy"},{"name":"National Biodiversity Future Center (NBFC), 90133 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3082-2908","authenticated-orcid":false,"given":"Annalisa","family":"Salis","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-7143","authenticated-orcid":false,"given":"Mirko","family":"Benvenuti","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8769-2051","authenticated-orcid":false,"given":"Gianluca","family":"Damonte","sequence":"additional","affiliation":[{"name":"Department of Experimental Medicine (DIMES), Biochemistry Section, University of Genova, 16132 Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-6919","authenticated-orcid":false,"given":"Sonia","family":"Scarf\u00ec","sequence":"additional","affiliation":[{"name":"Centro 3R, Interuniversity Center for the Promotion of the Principles of the 3Rs in Teaching and Research, 56122 Pisa, Italy"},{"name":"Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, 16132 Genova, Italy"},{"name":"National Biodiversity Future Center (NBFC), 90133 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1111\/j.1529-8817.2012.01222.x","article-title":"How Many Species of Algae Are There?","volume":"48","author":"Guiry","year":"2012","journal-title":"J. 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