{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:50:54Z","timestamp":1793040654890,"version":"4.5.0"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"framework of the state assignment registration","award":["1023022100045-0"],"award-info":[{"award-number":["1023022100045-0"]}]},{"name":"framework of the state assignment registration","award":["122022800132-1"],"award-info":[{"award-number":["122022800132-1"]}]},{"name":"framework of the state assignment registration","award":["121030300149-0"],"award-info":[{"award-number":["121030300149-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The incidence of diseases brought on by resistant strains of micro-organisms, including tuberculosis, is rising globally as a result of the rapid rise in pathogenic micro-organism resistance to antimicrobial treatments. Secondary metabolites with potential for antibacterial activity are produced by cyanobacteria and microalgae. In this study, gram-positive (S. aureus, E. faecalis) and gram-negative (K. pneumoniae, A. baumannii, P. aeruginosa) bacteria were isolated from pulmonary tuberculosis patients receiving long-term antituberculosis therapy. The antimicrobial potential of extracts from the cyanobacteria Leptolyngbya cf. ectocarpi, Planktothrix agardhii, Arthrospira platensis, Rohotiella mixta sp. nov., Nanofrustulum shiloi, and Tetraselmis (Platymonas) viridis Rouchijajnen was evaluated. On mouse splenocytes and peritoneal macrophages, extracts of cyanobacteria and microalgae had inhibitory effects. In vitro studies have shown that cyanobacteria and microalgae extracts suppress the growth of bacteria and mycobacteria. At the same time, it has been demonstrated that cyanobacterial and microalgal extracts can encourage bacterial growth in a test tube. Additionally, the enhanced fucoxanthin fraction significantly reduced the development of bacteria in vitro. In a mouse experiment to simulate tuberculosis, the mycobacterial load in internal organs was considerably decreased by fucoxanthin. According to the information gathered, cyanobacteria and microalgae are potential sources of antibacterial compounds that can be used in the manufacturing of pharmaceutical raw materials.<\/jats:p>","DOI":"10.3390\/md21090492","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:06:13Z","timestamp":1694750773000},"page":"492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Study of the Antimicrobial Potential of the Arthrospira\u00a0platensis, Planktothrix agardhii, Leptolyngbya cf. ectocarpi, Roholtiella mixta nov., Tetraselmis viridis, and Nanofrustulum shiloi against Gram-Positive, Gram-Negative Bacteria, and Mycobacteria"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-8676","authenticated-orcid":false,"given":"Alexander","family":"Lykov","sequence":"first","affiliation":[{"name":"Novosibirsk Tuberculosis Research Institute MH RF, Okhotskaya 81 A, Novosibirsk 630040, Russia"},{"name":"Research Institute of Clinical and Experimental Lymphology\u2014Filial of the Institute of Cytology and Genetics, Timakova 2, Novosibirsk 630060, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8323-6513","authenticated-orcid":false,"given":"Alexei","family":"Salmin","sequence":"additional","affiliation":[{"name":"Novosibirsk Tuberculosis Research Institute MH RF, Okhotskaya 81 A, Novosibirsk 630040, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8017-5593","authenticated-orcid":false,"given":"Ruslan","family":"Gevorgiz","sequence":"additional","affiliation":[{"name":"Kovalevsky Research Institute of Biology of Southern Seas RAS, Nakhimova 2, Sevastopol 299011, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Zheleznova","sequence":"additional","affiliation":[{"name":"Kovalevsky Research Institute of Biology of Southern Seas RAS, Nakhimova 2, Sevastopol 299011, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov","family":"Rachkovskaya","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology\u2014Filial of the Institute of Cytology and Genetics, Timakova 2, Novosibirsk 630060, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4752-988X","authenticated-orcid":false,"given":"Maria","family":"Surovtseva","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology\u2014Filial of the Institute of Cytology and Genetics, Timakova 2, Novosibirsk 630060, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Poveshchenko","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical and Experimental Lymphology\u2014Filial of the Institute of Cytology and Genetics, Timakova 2, Novosibirsk 630060, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.29296\/25877313-2021-07-04","article-title":"Microalgae as a new source of biologically active compounds with antibacterial activity","volume":"24","author":"Mitishev","year":"2021","journal-title":"Probl. 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