{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T03:39:37Z","timestamp":1781408377628,"version":"3.54.1"},"reference-count":100,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T00:00:00Z","timestamp":1697932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Foundation of Zhejiang Province","award":["LGF21H300003"],"award-info":[{"award-number":["LGF21H300003"]}]},{"name":"Natural Foundation of Zhejiang Province","award":["2022YFC2804104"],"award-info":[{"award-number":["2022YFC2804104"]}]},{"name":"Natural Foundation of Zhejiang Province","award":["2022YFC2804205"],"award-info":[{"award-number":["2022YFC2804205"]}]},{"name":"Natural Foundation of Zhejiang Province","award":["42276137"],"award-info":[{"award-number":["42276137"]}]},{"name":"Natural Foundation of Zhejiang Province","award":["2021C03084"],"award-info":[{"award-number":["2021C03084"]}]},{"name":"National Key Research and Development Program of China","award":["LGF21H300003"],"award-info":[{"award-number":["LGF21H300003"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFC2804104"],"award-info":[{"award-number":["2022YFC2804104"]}]},{"name":"National Key Research and Development Program of China","award":["2022YFC2804205"],"award-info":[{"award-number":["2022YFC2804205"]}]},{"name":"National Key Research and Development Program of China","award":["42276137"],"award-info":[{"award-number":["42276137"]}]},{"name":"National Key Research and Development Program of China","award":["2021C03084"],"award-info":[{"award-number":["2021C03084"]}]},{"name":"National Natural Science Foundation of China","award":["LGF21H300003"],"award-info":[{"award-number":["LGF21H300003"]}]},{"name":"National Natural Science Foundation of China","award":["2022YFC2804104"],"award-info":[{"award-number":["2022YFC2804104"]}]},{"name":"National Natural Science Foundation of China","award":["2022YFC2804205"],"award-info":[{"award-number":["2022YFC2804205"]}]},{"name":"National Natural Science Foundation of China","award":["42276137"],"award-info":[{"award-number":["42276137"]}]},{"name":"National Natural Science Foundation of China","award":["2021C03084"],"award-info":[{"award-number":["2021C03084"]}]},{"name":"Key Research and Development Program of Zhejiang Province","award":["LGF21H300003"],"award-info":[{"award-number":["LGF21H300003"]}]},{"name":"Key Research and Development Program of Zhejiang Province","award":["2022YFC2804104"],"award-info":[{"award-number":["2022YFC2804104"]}]},{"name":"Key Research and Development Program of Zhejiang Province","award":["2022YFC2804205"],"award-info":[{"award-number":["2022YFC2804205"]}]},{"name":"Key Research and Development Program of Zhejiang Province","award":["42276137"],"award-info":[{"award-number":["42276137"]}]},{"name":"Key Research and Development Program of Zhejiang Province","award":["2021C03084"],"award-info":[{"award-number":["2021C03084"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>In the post-antibiotic era, the rapid development of antibiotic resistance and the shortage of available antibiotics are triggering a new health-care crisis. The discovery of novel and potent antibiotics to extend the antibiotic pipeline is urgent. Small-molecule antimicrobial peptides have a wide variety of antimicrobial spectra and multiple innovative antimicrobial mechanisms due to their rich structural diversity. Consequently, they have become a new research hotspot and are considered to be promising candidates for next-generation antibiotics. Therefore, we have compiled a collection of small-molecule antimicrobial peptides derived from marine microorganisms from the last fifteen years to show the recent advances in this field. We categorize these compounds into three classes\u2014cyclic oligopeptides, cyclic depsipeptides, and cyclic lipopeptides\u2014according to their structural features, and present their sources, structures, and antimicrobial spectrums, with a discussion of the structure activity relationships and mechanisms of action of some compounds.<\/jats:p>","DOI":"10.3390\/md21100547","type":"journal-article","created":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T07:02:53Z","timestamp":1697958173000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Recent Advances in Polypeptide Antibiotics Derived from Marine Microorganisms"],"prefix":"10.3390","volume":"21","author":[{"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Gu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xubin","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wei","sequence":"additional","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2430-3845","authenticated-orcid":false,"given":"Huawei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-060X","authenticated-orcid":false,"given":"Hong","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5819-8441","authenticated-orcid":false,"given":"Jianwei","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education & Key Laboratory Pharmaceutical Engineering of Zhejiang Province & College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00253-011-3587-6","article-title":"Penicillin: The medicine with the greatest impact on therapeutic outcomes","volume":"92","author":"Kardos","year":"2011","journal-title":"Appl. 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