{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:26:21Z","timestamp":1772803581153,"version":"3.50.1"},"reference-count":81,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Northeast Bank of Brazil\u2014BNB","award":["482012"],"award-info":[{"award-number":["482012"]}]},{"name":"Northeast Bank of Brazil\u2014BNB","award":["478655\/2007-0"],"award-info":[{"award-number":["478655\/2007-0"]}]},{"name":"Northeast Bank of Brazil\u2014BNB","award":["465634\/2014-1"],"award-info":[{"award-number":["465634\/2014-1"]}]},{"name":"Northeast Bank of Brazil\u2014BNB","award":["309771\/2019-6"],"award-info":[{"award-number":["309771\/2019-6"]}]},{"name":"National Council for Scientific and Technological Development\u2014CNPq","award":["482012"],"award-info":[{"award-number":["482012"]}]},{"name":"National Council for Scientific and Technological Development\u2014CNPq","award":["478655\/2007-0"],"award-info":[{"award-number":["478655\/2007-0"]}]},{"name":"National Council for Scientific and Technological Development\u2014CNPq","award":["465634\/2014-1"],"award-info":[{"award-number":["465634\/2014-1"]}]},{"name":"National Council for Scientific and Technological Development\u2014CNPq","award":["309771\/2019-6"],"award-info":[{"award-number":["309771\/2019-6"]}]},{"name":"National Institute of Science and Technology of Tropical Marine Environments INCT AmbTropic","award":["482012"],"award-info":[{"award-number":["482012"]}]},{"name":"National Institute of Science and Technology of Tropical Marine Environments INCT AmbTropic","award":["478655\/2007-0"],"award-info":[{"award-number":["478655\/2007-0"]}]},{"name":"National Institute of Science and Technology of Tropical Marine Environments INCT AmbTropic","award":["465634\/2014-1"],"award-info":[{"award-number":["465634\/2014-1"]}]},{"name":"National Institute of Science and Technology of Tropical Marine Environments INCT AmbTropic","award":["309771\/2019-6"],"award-info":[{"award-number":["309771\/2019-6"]}]},{"name":"CNPq fellowship-honored researcher","award":["482012"],"award-info":[{"award-number":["482012"]}]},{"name":"CNPq fellowship-honored researcher","award":["478655\/2007-0"],"award-info":[{"award-number":["478655\/2007-0"]}]},{"name":"CNPq fellowship-honored researcher","award":["465634\/2014-1"],"award-info":[{"award-number":["465634\/2014-1"]}]},{"name":"CNPq fellowship-honored researcher","award":["309771\/2019-6"],"award-info":[{"award-number":["309771\/2019-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Fucans from marine algae have been the object of many studies that demonstrated a broad spectrum of biological activities, including anti-inflammatory effects. The aim of this study was to verify the protective effects of a fucan extracted from the brown algae Spatoglossum schr\u00f6ederi in animals submitted to a generalized inflammation model induced by zymosan (ZIGI). BALB\/c mice were first submitted to zymosan-induced peritonitis to evaluate the treatment dose capable of inhibiting the induced cellular migration in a simple model of inflammation. Mice were treated by the intravenous route with three doses (20, 10, and 5 mg\/kg) of our fucan and, 1 h later, were inoculated with an intraperitoneal dose of zymosan (40 mg\/kg). Peritoneal exudate was collected 24 h later for the evaluation of leukocyte migration. Doses of the fucan of Spatoglossum schr\u00f6ederi at 20 and 10 mg\/kg reduced peritoneal cellular migration and were selected to perform ZIGI experiments. In the ZIGI model, treatment was administered 1 h before and 6 h after the zymosan inoculation (500 mg\/kg). Treatments and challenges were administered via intravenous and intraperitoneal routes, respectively. Systemic toxicity was assessed 6 h after inoculation, based on three clinical signs (bristly hair, prostration, and diarrhea). The peritoneal exudate was collected to assess cellular migration and IL-6 levels, while blood samples were collected to determine IL-6, ALT, and AST levels. Liver tissue was collected for histopathological analysis. In another experimental series, weight loss was evaluated for 15 days after zymosan inoculation and fucan treatment. The fucan treatment did not present any effect on ZIGI systemic toxicity; however, a fucan dose of 20 mg\/kg was capable of reducing the weight loss in treated mice. The treatment with both doses also reduced the cellular migration and reduced IL-6 levels in peritoneal exudate and serum in doses of 20 and 10 mg\/kg, respectively. They also presented a protective effect in the liver, with a reduction in hepatic transaminase levels in both doses of treatment and attenuated histological damage in the liver at a dose of 10 mg\/kg. Fucan from S. schr\u00f6ederi presented a promising pharmacological activity upon the murine model of ZIGI, with potential anti-inflammatory and hepatic protective effects, and should be the target of profound and elucidative studies.<\/jats:p>","DOI":"10.3390\/md21110557","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T02:40:07Z","timestamp":1698288007000},"page":"557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti-Inflammatory Activity of Fucan from Spatoglossum schr\u00f6ederi in a Murine Model of Generalized Inflammation Induced by Zymosan"],"prefix":"10.3390","volume":"21","author":[{"given":"Ana Katarina Andrade","family":"Silva","sequence":"first","affiliation":[{"name":"Department of Microbiology and Parasitology, Department of Biochemistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"},{"name":"Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, EBSERH, Natal 59078-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7783-9862","authenticated-orcid":false,"given":"C\u00e1ssio Ricardo de Medeiros","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Department of Biochemistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"},{"name":"Biochemistry and Molecular Biology Post-Graduation Program, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hylarina Montenegro Diniz","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Department of Biochemistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"},{"name":"Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, EBSERH, Natal 59078-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica Teixeira","family":"Jales","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Department of Biochemistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Alves de Souza","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Department of Biochemistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericka Janine Dantas","family":"da Silveira","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, 1787, Lagoa Nova, Natal 59056-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2252-1221","authenticated-orcid":false,"given":"Hugo Alexandre Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Department of Biochemistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4115-4829","authenticated-orcid":false,"given":"Janeusa Trindade","family":"Souto","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Department of Biochemistry, Federal University of Rio Grande do Norte, Avenida Salgado Filho, BR 101, Campus Universitario, Lagoa Nova, Natal 59078-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"ref_1","first-page":"259","article-title":"Structure of the Cell Walls of Marine Algae and Ecophysiological Functions of the Matrix Polysaccharides","volume":"26","author":"Kloareg","year":"1988","journal-title":"Oceanogr. 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