{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:35:15Z","timestamp":1792805715895,"version":"4.5.0"},"reference-count":43,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Oceans and Fisheries, Republic of Korea","award":["20220027"],"award-info":[{"award-number":["20220027"]}],"id":[{"id":"https:\/\/ror.org\/00c5s4a53","id-type":"ROR","asserted-by":"crossref"}]},{"name":"\u2018Efficacy\/standardization technology development of marine healing resources and its life cycle safety\u2019 Project","award":["20220027"],"award-info":[{"award-number":["20220027"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>This study was conducted to estimate the effectiveness of marine-derived resources for treating specific diseases, as well as identify the most effective methods for applying such resources in therapeutic applications. Bibliographic databases (PubMed, Embase, and Cochrane) were searched from their inception until May 2023 using Medical Subject Headings terms and text keywords related to seawater, mineral water, or ocean therapy. Fifteen eligible studies were included, involving 1325 participants aged 42.7\u201363.0 years. In the subgroup analysis based on treatment type, the mean difference was \u22121.581 (95% CI: \u22121.889, \u22121.274) for seawater with sun exposure and \u22121.210 (95% CI: \u22121.417, \u22121.002) for seawater with sun exposure, mud pack application, and sulfur pool therapy. The pooled standardized mean difference was calculated for different outcomes; the results were \u22121.110 (95% CI: \u22123.028, 0.806) for osteoarthritis severity, \u22120.795 (95% CI: \u22120.982, \u22120.607) for arthritis pain, \u22121.623 (95% CI: \u22122.036, \u22121.209) for fibromyalgia pain, and \u22121.498 (95% CI: \u22121.888, \u22121.108) for quality of life. Marine therapy is, therefore, promising for treating chronic skin issues, easing musculoskeletal discomfort, and enhancing the quality of life among patients with musculoskeletal pain.<\/jats:p>","DOI":"10.3390\/md21120604","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T11:31:25Z","timestamp":1700739085000},"page":"604","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Unveiling the Therapeutic Potential and Healthcare Applications of Marine Therapy: A Systematic Review with Meta-Analysis and Meta-Regression"],"prefix":"10.3390","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4143-7383","authenticated-orcid":false,"given":"Sung Ryul","family":"Shim","sequence":"first","affiliation":[{"name":"Department of Biomedical Informatics, College of Medicine, Konyang University, Daejeon 35365, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-184X","authenticated-orcid":false,"given":"Dayeon","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food and Nutrition, Inha University, Incheon 22212, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong-Jang","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, College of Medicine, Pusan National University, Yangsan 50612, Republic of Korea"},{"name":"BioMedical Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan 50612, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6037-8449","authenticated-orcid":false,"given":"Young Kook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, College of Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea"},{"name":"EyeLight Data Science Laboratory, Seoul 03080, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s Rehabilitation, National Rehabilitation Center, Seoul 01022, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"ref_1","unstructured":"(2020). 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