{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:05:29Z","timestamp":1790103929512,"version":"4.0.1"},"reference-count":48,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"POR Campania FESR 2014\u20132020 \u201cTechnology Platform for Therapeutic Strategies against Cancer\u201d\u2014Action 1.2.1 and 1.2.2.","award":["CUP B43D18000240007\u2013SURF 17061BP000000011"],"award-info":[{"award-number":["CUP B43D18000240007\u2013SURF 17061BP000000011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine invertebrates are a traditional source of natural products with relevant biological properties. Tunicates are soft-bodied, solitary or colonial, sessile organisms that provide compounds unique in their structure and activity. The aim of this work was to investigate the chemical composition of the ascidian Cystodytes dellechiajei, selected on the basis of a positive result in biological screening for ligands of relevant receptors of the innate immune system, including TLR2, TLR4, dectin-1b, and TREM2. Bioassay-guided screening of this tunicate extract yielded two known pyridoacridine alkaloids, shermilamine B (1) and N-deacetylshermilamine B (2), and a family of methyl-branched cerebrosides (3). Compounds 2 and 3 showed selective binding to TREM2 in a dose-dependent manner. N-deacetylshermilamine B (2), together with its acetylated analogue, shermilamine B (1), was also strongly cytotoxic against multiple myeloma cell lines. TREM2 is involved in immunomodulatory processes and neurodegenerative diseases. N-deacetylshermilamine B (2) is the first example of a polycyclic alkaloid to show an affinity for this receptor.<\/jats:p>","DOI":"10.3390\/md22020075","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T09:56:34Z","timestamp":1706694994000},"page":"75","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Chemical and Pharmacological Prospection of the Ascidian Cystodytes dellechiajei"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7185-4981","authenticated-orcid":false,"given":"Pedro Jatai","family":"Batista","sequence":"first","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7065-2379","authenticated-orcid":false,"given":"Genoveffa","family":"Nuzzo","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1665-2615","authenticated-orcid":false,"given":"Carmela","family":"Gallo","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalila","family":"Carbone","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6258-8407","authenticated-orcid":false,"given":"Mario","family":"dell\u2019Isola","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7980-3526","authenticated-orcid":false,"given":"Mario","family":"Affuso","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2395-6710","authenticated-orcid":false,"given":"Giusi","family":"Barra","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Albiani","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2800-3735","authenticated-orcid":false,"given":"Fabio","family":"Crocetta","sequence":"additional","affiliation":[{"name":"Department of Integrative Marine Ecology, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy"},{"name":"NBFC\u2014National Biodiversity Future Center, Piazza Marina 61, 90133 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Virgili","sequence":"additional","affiliation":[{"name":"Department of Integrative Marine Ecology, Stazione Zoologica Anton Dohrn, 80121 Naples, Italy"},{"name":"NBFC\u2014National Biodiversity Future Center, Piazza Marina 61, 90133 Palermo, Italy"},{"name":"Laboratory of Bio-Organic Chemistry and Chemical Biology, Department of Biology, University of Naples \u201cFederico II\u201d, Via Cupa Nuova Cinthia 21, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8708-2392","authenticated-orcid":false,"given":"Valerio","family":"Mazzella","sequence":"additional","affiliation":[{"name":"NBFC\u2014National Biodiversity Future Center, Piazza Marina 61, 90133 Palermo, Italy"},{"name":"Ischia Marine Centre, Department of Integrative Marine Ecology, Stazione Zoologica Anton Dohrn, 80077 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-8644","authenticated-orcid":false,"given":"Daniela","family":"Castiglia","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliana","family":"d\u2019Ippolito","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7394-020X","authenticated-orcid":false,"given":"Emiliano","family":"Manzo","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5453-461X","authenticated-orcid":false,"given":"Angelo","family":"Fontana","sequence":"additional","affiliation":[{"name":"Bio-Organic Chemistry Unit, Institute of Biomolecular Chemistry CNR, Via Campi Flegrei 34, 80078 Naples, Italy"},{"name":"Laboratory of Bio-Organic Chemistry and Chemical Biology, Department of Biology, University of Naples \u201cFederico II\u201d, Via Cupa Nuova Cinthia 21, 80126 Napoli, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"105011","DOI":"10.1016\/j.arabjc.2023.105011","article-title":"Chemical diversity and biological activities of marine-derived sulphur containing alkaloids: A comprehensive update","volume":"16","author":"Zhang","year":"2023","journal-title":"Arab. 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