{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:22:04Z","timestamp":1780089724720,"version":"3.54.0"},"reference-count":28,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2023B1111050008"],"award-info":[{"award-number":["2023B1111050008"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["GDNRC [2022]35"],"award-info":[{"award-number":["GDNRC [2022]35"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2021A1515011711"],"award-info":[{"award-number":["2021A1515011711"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2021A1515410002"],"award-info":[{"award-number":["2021A1515410002"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2020A1515110560"],"award-info":[{"award-number":["2020A1515110560"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province","award":["GZC20232777"],"award-info":[{"award-number":["GZC20232777"]}]},{"name":"Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province","award":["2023B1111050008"],"award-info":[{"award-number":["2023B1111050008"]}]},{"name":"Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province","award":["GDNRC [2022]35"],"award-info":[{"award-number":["GDNRC [2022]35"]}]},{"name":"Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province","award":["2021A1515011711"],"award-info":[{"award-number":["2021A1515011711"]}]},{"name":"Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province","award":["2021A1515410002"],"award-info":[{"award-number":["2021A1515410002"]}]},{"name":"Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province","award":["2020A1515110560"],"award-info":[{"award-number":["2020A1515110560"]}]},{"name":"Special Funds for Promoting Economic Development (Marine Economic Development) of Guangdong Province","award":["GZC20232777"],"award-info":[{"award-number":["GZC20232777"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["2023B1111050008"],"award-info":[{"award-number":["2023B1111050008"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["GDNRC [2022]35"],"award-info":[{"award-number":["GDNRC [2022]35"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["2021A1515011711"],"award-info":[{"award-number":["2021A1515011711"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["2021A1515410002"],"award-info":[{"award-number":["2021A1515410002"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["2020A1515110560"],"award-info":[{"award-number":["2020A1515110560"]}]},{"name":"Natural Science Foundation of Guangdong Province","award":["GZC20232777"],"award-info":[{"award-number":["GZC20232777"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["2023B1111050008"],"award-info":[{"award-number":["2023B1111050008"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GDNRC [2022]35"],"award-info":[{"award-number":["GDNRC [2022]35"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["2021A1515011711"],"award-info":[{"award-number":["2021A1515011711"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["2021A1515410002"],"award-info":[{"award-number":["2021A1515410002"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["2020A1515110560"],"award-info":[{"award-number":["2020A1515110560"]}]},{"name":"Postdoctoral Fellowship Program of CPSF","award":["GZC20232777"],"award-info":[{"award-number":["GZC20232777"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Two new sesquiterpenoid derivatives, elgonenes M (1) and N (2), and a new shikimic acid metabolite, methyl 5-O-acetyl-5-epi-shikimate (3), were isolated from the mangrove sediment-derived fungus Roussoella sp. SCSIO 41427 together with fourteen known compounds (4\u201317). The planar structures were elucidated through nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. The relative configurations of 1\u20133 were ascertained by NOESY experiments, while their absolute configurations were determined by electronic circular dichroism (ECD) calculation. Elgonene M (1) exhibited inhibition of interleukin-1\u03b2 (IL-1\u03b2) mRNA, a pro-inflammatory cytokine, at a concentration of 5 \u03bcM, with an inhibitory ratio of 31.14%. On the other hand, elgonene N (2) demonstrated inhibition at a concentration of 20 \u03bcM, with inhibitory ratios of 27.57%.<\/jats:p>","DOI":"10.3390\/md22030103","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T10:47:30Z","timestamp":1708685250000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Two New Sesquiterpenoids and a New Shikimic Acid Metabolite from Mangrove Sediment-Derived Fungus Roussoella sp. SCSIO 41427"],"prefix":"10.3390","volume":"22","author":[{"given":"Zimin","family":"Xiao","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cai","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Stomatology, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1375-8176","authenticated-orcid":false,"given":"Yilin","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Stomatology, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Chen","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Chen","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4748-2484","authenticated-orcid":false,"given":"Bin","family":"Yang","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-4869","authenticated-orcid":false,"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-1345","authenticated-orcid":false,"given":"Huaming","family":"Tao","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Sun, Y., Chen, P., Zhai, B., Zhang, M., Xiang, Y., Fang, J., Xu, S., Gao, Y., Chen, X., and Sui, X. (2020). The Emerging Role of Ferroptosis in Inflammation. Biomed. Pharmacother., 127.","DOI":"10.1016\/j.biopha.2020.110108"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Coxib and traditional NSAID Trialists\u2019 (CNT) Collaboration, Bhala, N., Emberson, J., Merhi, A., Abramson, S., Arber, N., Baron, J.A., Bombardier, C., Cannon, C., and Farkouh, M.E. (2013). Vascular and Upper Gastrointestinal Effects of Non-Steroidal Anti-Inflammatory Drugs: Meta-Analyses of Individual Participant Data from Randomised Trials. Lancet, 382, 769\u2013779.","DOI":"10.1016\/S0140-6736(13)60900-9"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1039\/D2NP00083K","article-title":"Marine Natural Products","volume":"40","author":"Carroll","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"114117","DOI":"10.1016\/j.ejmech.2022.114117","article-title":"Natural Products from Mangrove Sediments-Derived Microbes: Structural Diversity, Bioactivities, Biosynthesis, and Total Synthesis","volume":"230","author":"Li","year":"2022","journal-title":"Eur. J. Med. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/mpp.12162","article-title":"The Past, Present and Future of Secondary Metabolite Research in the Dothideomycetes","volume":"16","author":"Chooi","year":"2015","journal-title":"Mol. Plant Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1021\/np400045z","article-title":"Roussoellols A and B, Tetracyclic Fusicoccanes from Roussoella Hysterioides","volume":"76","author":"Takekawa","year":"2013","journal-title":"J. Nat. Prod."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Phukhamsakda, C., Macabeo, A.P.G., Yuyama, K.T., Hyde, K.D., and Stadler, M. (2018). Biofilm Inhibitory Abscisic Acid Derivatives from the Plant-Associated Dothideomycete Fungus, Roussoella Sp.. Molecules, 23.","DOI":"10.3390\/molecules23092190"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Chen, C., Ren, X., Tao, H., Cai, W., Chen, Y., Luo, X., Guo, P., and Liu, Y. (2022). Anti-Inflammatory Polyketides from an Alga-Derived Fungus Aspergillus ochraceopetaliformis SCSIO 41020. Mar. Drugs, 20.","DOI":"10.3390\/md20050295"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Peng, B., Cai, J., Xiao, Z., Liu, M., Li, X., Yang, B., Fang, W., Huang, Y., Chen, C., and Zhou, X. (2023). Bioactive Polyketides and Benzene Derivatives from Two Mangrove Sediment-Derived Fungi in the Beibu Gulf. Mar. Drugs, 21.","DOI":"10.3390\/md21060327"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ye, Y., Liang, J., She, J., Lin, X., Wang, J., Liu, Y., Yang, D., Tan, Y., Luo, X., and Zhou, X. (2023). Two New Alkaloids and a New Butenolide Derivative from the Beibu Gulf Sponge-Derived Fungus Penicillium sp. SCSIO 41413. Mar. Drugs, 21.","DOI":"10.3390\/md21010027"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"5401","DOI":"10.1016\/j.tet.2006.03.074","article-title":"Influence of Intramolecular Hydrogen Bonds in the Enzyme-Catalyzed Regioselective Acylation of Quinic and Shikimic Acid Derivatives","volume":"62","author":"Armesto","year":"2006","journal-title":"Tetrahedron"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1021\/acs.jnatprod.8b01086","article-title":"Sesquiterpenes from an Eastern African Medicinal Mushroom Belonging to the Genus Sanghuangporus","volume":"82","author":"Cheng","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/10575639408044041","article-title":"Isocoumarins of the Fungus Ceratocystis Fimbriata coffea","volume":"5","author":"Gremaud","year":"1994","journal-title":"Nat. Prod. Lett."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1016\/j.tet.2017.02.019","article-title":"Polyketides from the Endophytic Fungus Phomopsis sp. Sh917 by Using the One Strain\/Many Compounds Strategy","volume":"73","author":"Tang","year":"2017","journal-title":"Tetrahedron"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.1016\/j.tetlet.2015.07.048","article-title":"Isochromanone Derivatives from the Endophytic Fungus Fusarium sp. PDB51F5","volume":"56","author":"Boonyaketgoson","year":"2015","journal-title":"Tetrahedron Lett."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1271\/bbb.110621","article-title":"Absolute Stereochemistry of Novel Isochromanone Derivatives from Leptosphaeria sp. KTC 727","volume":"75","author":"Tayone","year":"2011","journal-title":"Biosci. Biotech. Bioch."},{"key":"ref_17","first-page":"1165","article-title":"Study on the Secondary Metabolites from the Deep-Sea-Derived Fungus Neoroussoella sp. and Their Biological Activities","volume":"33","author":"Zhong","year":"2021","journal-title":"Nat. Prod. Res. Dev."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"6695","DOI":"10.1016\/j.tetlet.2013.09.060","article-title":"Saccharonol B, a New Cytotoxic Methylated Isocoumarin from Saccharomonospora azurea","volume":"54","author":"Singh","year":"2013","journal-title":"Tetrahedron Lett."},{"key":"ref_19","first-page":"2555","article-title":"Polymer-Bound Cationic Rh(I) Phosphine Catalyst for Homogeneous Asymmetric Hydrogenation","volume":"44B","author":"Koshti","year":"2005","journal-title":"Indian J. Chem. B"},{"key":"ref_20","first-page":"51","article-title":"Chemical Constituents of Endophytic Fungus Hypocreales sp. Derived from the Red Alga Symphyocladia Latiuscula","volume":"32","author":"Li","year":"2008","journal-title":"Haiyang Kexue."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1007\/BF02975427","article-title":"Constituents of the Halophyte Salicornia Herbacea","volume":"27","author":"Lee","year":"2004","journal-title":"Arch. Pharmacal Res."},{"key":"ref_22","first-page":"42","article-title":"Study on Anti-HBV Secondary Metabolites from Sponge-associated Fungus Penicillium janthinellum LZDX-32-1","volume":"36","author":"Cui","year":"2017","journal-title":"Chin. J. Mar. Drugs"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s00044-021-02777-8","article-title":"Bioassay-Guided Isolation and Identification of Anti-Alzheimer\u2019s Active Compounds from Spiranthes Sinensis (Pers.) Ames","volume":"30","author":"Zou","year":"2021","journal-title":"Med. Chem. Res."},{"key":"ref_24","first-page":"77","article-title":"Chemical Constituents in the Fruits of Mangrove Plant Sonneratia Apetala Buch. Ham","volume":"34","author":"Cao","year":"2015","journal-title":"J. Trop. Oceanogr."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/eji.201141550","article-title":"Clinical Perspective of IL-1\u03b2 as the Gatekeeper of Inflammation","volume":"41","author":"Dinarello","year":"2011","journal-title":"Eur. J. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.phytol.2023.03.006","article-title":"Bisabolane and Drimane Sesquiterpenes from the Fungus Coprinellus sp.","volume":"55","author":"Chi","year":"2023","journal-title":"Phytochem. Lett."},{"key":"ref_27","first-page":"1767","article-title":"Sesquiterpenes from Essential Oils and Anti-Inflammatory Activity","volume":"10","author":"Andrade","year":"2015","journal-title":"Nat. Prod. Commun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1021\/acs.jnatprod.7b01053","article-title":"Isochromophilones A\u2013F, Cytotoxic Chloroazaphilones from the Marine Mangrove Endophytic Fungus Diaporthe sp. SCSIO 41011","volume":"81","author":"Luo","year":"2018","journal-title":"J. Nat. Prod."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/3\/103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:04:02Z","timestamp":1760105042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/3\/103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,23]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["md22030103"],"URL":"https:\/\/doi.org\/10.3390\/md22030103","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,23]]}}}