{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:45:36Z","timestamp":1790631936165,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Fisheries science, Food safety and Processing Research Division","award":["2024058"],"award-info":[{"award-number":["2024058"]}]},{"name":"National Institute of Fisheries science, Food safety and Processing Research Division","award":["202202240002"],"award-info":[{"award-number":["202202240002"]}]},{"name":"National Institute of Fisheries science, Food safety and Processing Research Division","award":["202312170001"],"award-info":[{"award-number":["202312170001"]}]},{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["2024058"],"award-info":[{"award-number":["2024058"]}]},{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["202202240002"],"award-info":[{"award-number":["202202240002"]}]},{"name":"National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["202312170001"],"award-info":[{"award-number":["202312170001"]}]},{"name":"Pukyong National University Industry-university Cooperation Research Fund","award":["2024058"],"award-info":[{"award-number":["2024058"]}]},{"name":"Pukyong National University Industry-university Cooperation Research Fund","award":["202202240002"],"award-info":[{"award-number":["202202240002"]}]},{"name":"Pukyong National University Industry-university Cooperation Research Fund","award":["202312170001"],"award-info":[{"award-number":["202312170001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The anti-inflammatory effect of the ethanol extract of Sargassum yezoense and its fractions were investigated in this study. The ethanol extract exhibited a strong anti-inflammatory effect on lipopolysaccharide-stimulated RAW 264.7 macrophages and effectively suppressed the M1 polarization of murine bone-marrow-derived macrophages stimulated by lipopolysaccharides and IFN-\u03b3 (interferon-gamma). Through a liquid\u2013liquid extraction process, five fractions (n-hexane, chloroform, ethyl acetate, butanol, and aqueous) were acquired. Among these fractions, the chloroform fraction (SYCF) was found to contain the highest concentration of phenolic compounds, along with two primary meroterpenoids, sargahydroquinoic acid (SHQA) and sargachromenol (SCM), and exhibit significant antioxidant capacity. It also demonstrated a robust anti-inflammatory effect. A direct comparison was conducted to assess the relative contribution of SHQA and SCM to the anti-inflammatory properties of SYCF. The concentrations of SHQA and SCM tested were determined based on their relative abundance in SYCF. SHQA contributed to a significant portion of the anti-inflammatory property of SYCF, while SCM played a limited role. These findings not only highlight the potential of the chloroform\u2013ethanol fractionation approach for concentrating meroterpenoids in S. yezoense but also demonstrate that SHQA and other bioactive compounds work additively or synergistically to produce the potent anti-inflammatory effect of SYCF.<\/jats:p>","DOI":"10.3390\/md22030107","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T03:34:04Z","timestamp":1708918444000},"page":"107","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The Role of Sargahydroquinoic Acid and Sargachromenol in the Anti-Inflammatory Effect of Sargassum yezoense"],"prefix":"10.3390","volume":"22","author":[{"given":"Yena","family":"Park","sequence":"first","affiliation":[{"name":"Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Food Science and Biotechnology, Gachon University, Seongnam 13120, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhyeon","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9261-2247","authenticated-orcid":false,"given":"Seungjin","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Jung","family":"Yun","sequence":"additional","affiliation":[{"name":"Food Safety and Processing Research Division, National Institute of Fisheries Science, Busan 46083, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2598-6066","authenticated-orcid":false,"given":"Mi-Bo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, College of Fisheries Science, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Gil","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea"},{"name":"Department of Food Science and Nutrition, College of Fisheries Science, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"5195","DOI":"10.1002\/fsn3.1835","article-title":"Therapeutic and nutraceutical potentials of a brown seaweed Sargassum fusiforme","volume":"8","author":"Liu","year":"2020","journal-title":"Food Sci. 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