{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T21:54:45Z","timestamp":1772315685659,"version":"3.50.1"},"reference-count":41,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["NSTC 112-2628-B-110-005"],"award-info":[{"award-number":["NSTC 112-2628-B-110-005"]}]},{"name":"National Science and Technology Council, Taiwan","award":["ZBH108-25"],"award-info":[{"award-number":["ZBH108-25"]}]},{"name":"National Science and Technology Council, Taiwan","award":["KAFGH-ZY-A-112016"],"award-info":[{"award-number":["KAFGH-ZY-A-112016"]}]},{"name":"Zuoying Armed Forces General Hospital","award":["NSTC 112-2628-B-110-005"],"award-info":[{"award-number":["NSTC 112-2628-B-110-005"]}]},{"name":"Zuoying Armed Forces General Hospital","award":["ZBH108-25"],"award-info":[{"award-number":["ZBH108-25"]}]},{"name":"Zuoying Armed Forces General Hospital","award":["KAFGH-ZY-A-112016"],"award-info":[{"award-number":["KAFGH-ZY-A-112016"]}]},{"name":"Tzu-Hui Institute of Technology","award":["NSTC 112-2628-B-110-005"],"award-info":[{"award-number":["NSTC 112-2628-B-110-005"]}]},{"name":"Tzu-Hui Institute of Technology","award":["ZBH108-25"],"award-info":[{"award-number":["ZBH108-25"]}]},{"name":"Tzu-Hui Institute of Technology","award":["KAFGH-ZY-A-112016"],"award-info":[{"award-number":["KAFGH-ZY-A-112016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Octocoral of the genus Clavularia is a kind of marine invertebrate possessing abundant cytotoxic secondary metabolites, such as prostanoids and dolabellanes. In our continuous natural product study of C. spp., two previously undescribed prostanoids [clavulone I-15-one (1) and 12-O-deacetylclavulone I (2)] and eleven known analogs (3\u201313) were identified. The structures of these new compounds were elucidated based on analysis of their 1D and 2D NMR, HRESIMS, and IR data. Additionally, all tested prostanoids (1 and 3\u201313) showed potent cytotoxic activities against the human oral cancer cell line (Ca9-22). The major compound 3 showed cytotoxic activity against the Ca9-22 cells with the IC50 value of 2.11 \u00b1 0.03 \u03bcg\/mL, which echoes the cytotoxic effect of the coral extract. In addition, in silico tools were used to predict the possible effects of isolated compounds on human tumor cell lines and nitric oxide production, as well as the pharmacological potentials.<\/jats:p>","DOI":"10.3390\/md22050219","type":"journal-article","created":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T03:35:55Z","timestamp":1715744155000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Marine Prostanoids with Cytotoxic Activity from Octocoral Clavularia spp."],"prefix":"10.3390","volume":"22","author":[{"given":"Ming-Ya","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I-Chi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Division of Pharmacy, Zuoying Armed Forces General Hospital, Kaohsiung 813204, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0370-1553","authenticated-orcid":false,"given":"Shi-Ying","family":"Huang","sequence":"additional","affiliation":[{"name":"College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Ting","family":"Chuang","sequence":"additional","affiliation":[{"name":"PhD Program in Life Sciences, Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tzi-Yi","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-2366","authenticated-orcid":false,"given":"Hsueh-Wei","family":"Chang","sequence":"additional","affiliation":[{"name":"PhD Program in Life Sciences, Department of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Center for Cancer Research, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"},{"name":"Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 807378, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian-Huei","family":"Chu","sequence":"additional","affiliation":[{"name":"Medical Laboratory, Medical Education and Research Center, Kaohsiung Armed Forces General Hospital, Kaohsiung 802301, Taiwan"},{"name":"Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 804201, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Yeu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Tzu-Hui Institute of Technology, Pingtung 926001, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6581-1320","authenticated-orcid":false,"given":"Yuan-Bin","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804201, Taiwan"},{"name":"Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807378, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,5,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0040-4020(01)96467-1","article-title":"New prostanoids from soft coral","volume":"41","author":"Kitagawa","year":"1985","journal-title":"Tetrahedron"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1021\/np010106n","article-title":"Cytotoxic dolabellane diterpenes from the Formosan soft coral Clavularia inflata","volume":"64","author":"Duh","year":"2001","journal-title":"J. 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