{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:02:03Z","timestamp":1787504523632,"version":"build-2736575974"},"reference-count":0,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China","award":["P2022-KF07"],"award-info":[{"award-number":["P2022-KF07"]}]},{"name":"Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China","award":["MDME2308-04"],"award-info":[{"award-number":["MDME2308-04"]}]},{"name":"Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China","award":["TICMBR202304"],"award-info":[{"award-number":["TICMBR202304"]}]},{"name":"Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China","award":["GXMNPCBC-2023-01"],"award-info":[{"award-number":["GXMNPCBC-2023-01"]}]},{"name":"Open Research Fund Program of Key Laboratory of Marine Drugs (Ocean University of China), Ministry of Education","award":["P2022-KF07"],"award-info":[{"award-number":["P2022-KF07"]}]},{"name":"Open Research Fund Program of Key Laboratory of Marine Drugs (Ocean University of China), Ministry of Education","award":["MDME2308-04"],"award-info":[{"award-number":["MDME2308-04"]}]},{"name":"Open Research Fund Program of Key Laboratory of Marine Drugs (Ocean University of China), Ministry of Education","award":["TICMBR202304"],"award-info":[{"award-number":["TICMBR202304"]}]},{"name":"Open Research Fund Program of Key Laboratory of Marine Drugs (Ocean University of China), Ministry of Education","award":["GXMNPCBC-2023-01"],"award-info":[{"award-number":["GXMNPCBC-2023-01"]}]},{"name":"Fund of the Technology Innovation Center for Exploitation of Marine Biological Resources, MNR","award":["P2022-KF07"],"award-info":[{"award-number":["P2022-KF07"]}]},{"name":"Fund of the Technology Innovation Center for Exploitation of Marine Biological Resources, MNR","award":["MDME2308-04"],"award-info":[{"award-number":["MDME2308-04"]}]},{"name":"Fund of the Technology Innovation Center for Exploitation of Marine Biological Resources, MNR","award":["TICMBR202304"],"award-info":[{"award-number":["TICMBR202304"]}]},{"name":"Fund of the Technology Innovation Center for Exploitation of Marine Biological Resources, MNR","award":["GXMNPCBC-2023-01"],"award-info":[{"award-number":["GXMNPCBC-2023-01"]}]},{"name":"Opening Project of Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry","award":["P2022-KF07"],"award-info":[{"award-number":["P2022-KF07"]}]},{"name":"Opening Project of Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry","award":["MDME2308-04"],"award-info":[{"award-number":["MDME2308-04"]}]},{"name":"Opening Project of Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry","award":["TICMBR202304"],"award-info":[{"award-number":["TICMBR202304"]}]},{"name":"Opening Project of Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry","award":["GXMNPCBC-2023-01"],"award-info":[{"award-number":["GXMNPCBC-2023-01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The prevention and treatment of liver disease, a class of disease that seriously threatens human health, has always been a hot topic of medical research. In recent years, with the in-depth exploration of marine resources, marine natural products have shown great potential and value in the field of liver disease treatment. Compounds extracted and isolated from marine natural products have a variety of biological activities such as significant antiviral properties, showing potential in the management of alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD), protection of the liver from fibrosis, protection from liver injury and inhibition of the growth of hepatocellular carcinoma (HCC). This paper summarizes the progress of research on marine natural products for the treatment of liver diseases in the past decade, including the structural types of active substances from different natural products and the mechanisms underlying the modulation of different liver diseases and reviews their future prospects.<\/jats:p>","DOI":"10.3390\/md22070288","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T08:50:08Z","timestamp":1718959808000},"page":"288","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Marine Natural Products on Liver Diseases"],"prefix":"10.3390","volume":"22","author":[{"given":"Yandi","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansong","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohe","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2344-1066","authenticated-orcid":false,"given":"Haifeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China"},{"name":"Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Guangxi Academy of Sciences, Nanning 530007, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,21]]},"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/7\/288\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:02:19Z","timestamp":1760108539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/7\/288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":0,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7]]}},"alternative-id":["md22070288"],"URL":"https:\/\/doi.org\/10.3390\/md22070288","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]}}}