{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:57:09Z","timestamp":1789509429807,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:00:00Z","timestamp":1725494400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Marine Economy Development Special Project","award":["GDNRC [2023]39"],"award-info":[{"award-number":["GDNRC [2023]39"]}]},{"name":"Guangdong Marine Economy Development Special Project","award":["U20A2001"],"award-info":[{"award-number":["U20A2001"]}]},{"name":"Guangdong Marine Economy Development Special Project","award":["42276114"],"award-info":[{"award-number":["42276114"]}]},{"name":"Guangdong Marine Economy Development Special Project","award":["22407145"],"award-info":[{"award-number":["22407145"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["GDNRC [2023]39"],"award-info":[{"award-number":["GDNRC [2023]39"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A2001"],"award-info":[{"award-number":["U20A2001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["42276114"],"award-info":[{"award-number":["42276114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22407145"],"award-info":[{"award-number":["22407145"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Twelve compounds, including four undescribed cytochalasins, xylariachalasins A\u2013D (1\u20134), four undescribed polyketides (5\u20138), and four known cytochalasins (9\u201312), were isolated from the mangrove endophytic fungus Xylaria arbuscula QYF. Their structures and absolute configurations were established by extensive spectroscopic analyses (1D and 2D NMR, HRESIMS), electronic circular dichroism (ECD) calculations, 13C NMR calculation and DP4+ analysis, single-crystal X-ray diffraction, and the modified Mosher ester method. Compounds 1 and 2 are rare cytochalasin hydroperoxides. In bioactivity assays, Compound 2 exhibited moderate antimicrobial activities against Staphylococcus aureus and Candida albicans with MIC values of 12.5 \u03bcM for both Compound 10 exhibited significant cytotoxic activity against MDA-MB-435 with an IC50 value of 3.61 \u00b1 1.60 \u03bcM.<\/jats:p>","DOI":"10.3390\/md22090407","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T05:30:02Z","timestamp":1725514202000},"page":"407","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Cytochalasins and Polyketides from a Mangrove Endophytic Fungus Xylaria arbuscula QYF"],"prefix":"10.3390","volume":"22","author":[{"given":"Qi","family":"Tan","sequence":"first","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Fu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3944-2609","authenticated-orcid":false,"given":"Yihao","family":"Yin","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufeng","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianying","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5676-3176","authenticated-orcid":false,"given":"Fei","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, Hebei University, Baoding 071002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingshun","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-0332","authenticated-orcid":false,"given":"Wencong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"},{"name":"School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0130-6701","authenticated-orcid":false,"given":"Zhigang","family":"She","sequence":"additional","affiliation":[{"name":"School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1039\/b807365a","article-title":"Natural products from true mangrove flora: Source, chemistry and bioactivities","volume":"25","author":"Wu","year":"2008","journal-title":"Nat. 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