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Furthermore, prolonged inflammation is undesirable, playing an important role in the development of various diseases, such as heart disease, diabetes, Alzheimer\u2019s disease, atherosclerosis, rheumatoid arthritis, and even certain cancers. Marine-derived fungi represent promising sources of structurally novel bioactive natural products, and have been a focus of research for the development of anti-inflammatory drugs. This review covers secondary metabolites with anti-inflammatory activities from marine-derived fungi, over the period spanning August 2018 to July 2024. A total of 285 anti-inflammatory metabolites, including 156 novel compounds and 11 with novel skeleton structures, are described. Their structures are categorized into five categories: terpenoids, polyketides, nitrogen-containing compounds, steroids, and other classes. The biological targets, as well as the in vitro and in vivo screening models, were surveyed and statistically summarized. This paper aims to offer valuable insights to researchers in the exploration of natural products and the discovery of anti-inflammatory drugs.<\/jats:p>","DOI":"10.3390\/md22100433","type":"journal-article","created":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T17:12:04Z","timestamp":1727284324000},"page":"433","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Natural Products from Marine-Derived Fungi with Anti-Inflammatory Activity"],"prefix":"10.3390","volume":"22","author":[{"given":"Yikang","family":"Qiu","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiji","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jueying","family":"Shi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key 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Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1779-8736","authenticated-orcid":false,"given":"Caijuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.14202\/vetworld.2018.627-635","article-title":"The crucial 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