{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:23:52Z","timestamp":1791102232646,"version":"4.1.0"},"reference-count":45,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Science and Technology Base Special Talents","award":["2021AC19424"],"award-info":[{"award-number":["2021AC19424"]}]},{"name":"Guangxi Science and Technology Base Special Talents","award":["2023GXNSFAA026228"],"award-info":[{"award-number":["2023GXNSFAA026228"]}]},{"name":"Guangxi Science and Technology Base Special Talents","award":["42006092"],"award-info":[{"award-number":["42006092"]}]},{"name":"Guangxi Science and Technology Base Special Talents","award":["CMEMR2020-A"],"award-info":[{"award-number":["CMEMR2020-A"]}]},{"name":"Guangxi Natural Science Foundation of China","award":["2021AC19424"],"award-info":[{"award-number":["2021AC19424"]}]},{"name":"Guangxi Natural Science Foundation of China","award":["2023GXNSFAA026228"],"award-info":[{"award-number":["2023GXNSFAA026228"]}]},{"name":"Guangxi Natural Science Foundation of China","award":["42006092"],"award-info":[{"award-number":["42006092"]}]},{"name":"Guangxi Natural Science Foundation of China","award":["CMEMR2020-A"],"award-info":[{"award-number":["CMEMR2020-A"]}]},{"name":"Program of National Natural Science Foundation of China","award":["2021AC19424"],"award-info":[{"award-number":["2021AC19424"]}]},{"name":"Program of National Natural Science Foundation of China","award":["2023GXNSFAA026228"],"award-info":[{"award-number":["2023GXNSFAA026228"]}]},{"name":"Program of National Natural Science Foundation of China","award":["42006092"],"award-info":[{"award-number":["42006092"]}]},{"name":"Program of National Natural Science Foundation of China","award":["CMEMR2020-A"],"award-info":[{"award-number":["CMEMR2020-A"]}]},{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)","award":["2021AC19424"],"award-info":[{"award-number":["2021AC19424"]}]},{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)","award":["2023GXNSFAA026228"],"award-info":[{"award-number":["2023GXNSFAA026228"]}]},{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)","award":["42006092"],"award-info":[{"award-number":["42006092"]}]},{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University)","award":["CMEMR2020-A"],"award-info":[{"award-number":["CMEMR2020-A"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Six new highly oxidized seco-terpenoids, including three 3-nor-labdane type diterpenes, talaroterpenoids A\u2013C (1\u20133), and three meroterpenoids containing an orthoester group, talaroterpenoids D\u2013F (6\u20138), together with five known compounds (4\u20135 and 9\u201311), were isolated from the marine-derived fungus Talaromyces aurantiacus. Their chemical structures were elucidated through 1D, 2D NMR, HRESIMS, J-based configuration analysis (JBCA), computational ECD calculations, and single-crystal X-ray diffraction analysis. Compounds 1 and 2 contain an unusual 6,20-\u03b3-lactone-bridged scaffold. Compounds 10 and 11 presented inhibitory effects on NO release in lipopolysaccharide (LPS)-induced BV-2 cells with IC50 values of 11.47 and 11.32 \u03bcM, respectively. Talaroterpenoid C (3) showed moderate antifungal activity against A. alternata and P. theae Steyaert.<\/jats:p>","DOI":"10.3390\/md22100475","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T06:46:52Z","timestamp":1729234012000},"page":"475","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Talaroterpenoids A\u2013F: Six New Seco-Terpenoids from the Marine-Derived Fungus Talaromyces aurantiacus"],"prefix":"10.3390","volume":"22","author":[{"given":"Zi-Hong","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Liang","family":"Luo","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Tong","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Han","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Design, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang-Ke","family":"Qin","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-2195","authenticated-orcid":false,"given":"Guo-Hai","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Yun","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2590-4820","authenticated-orcid":false,"given":"Wei-Feng","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1039\/D2NP00083K","article-title":"Marine natural products","volume":"40","author":"Carroll","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1007\/s42995-021-00101-2","article-title":"The intriguing chemistry and biology of sulfur-containing natural products from marine microorganisms (1987\u20132020)","volume":"3","author":"Hai","year":"2021","journal-title":"Mar. Life Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1021\/acs.orglett.5b01995","article-title":"(+)- and (\u2212)-Pestaloxazine A, a pair of antiviral enantiomeric alkaloid dimers with a symmetric spiro [oxazinane-piperazinedione] skeleton from Pestalotiopsis sp","volume":"17","author":"Jia","year":"2015","journal-title":"Org. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s42995-022-00157-8","article-title":"Targeted isolation of antitubercular cycloheptapeptides and an unusual pyrroloindoline-containing new analog, asperpyrroindotide A, using LC\u2013MS\/MS-based molecular networking","volume":"5","author":"Han","year":"2023","journal-title":"Mar. Life Sci. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Haque, N., Parveen, S., Tang, T., Wei, J., and Huang, Z. (2022). Marine natural products in clinical use. Mar. Drugs, 20.","DOI":"10.3390\/md20080528"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Cutolo, E.A., Campitiello, R., Caferri, R., Pagliuca, V.F., Li, J., Agathos, S.N., and Cutolo, M. (2024). Immunomodulatory compounds from the sea: From the origins to a modern marine pharmacopoeia. Mar. Drugs, 22.","DOI":"10.3390\/md22070304"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Zhang, K., Zhang, X., Lin, R., Yang, H., Song, F., Xu, X., and Wang, L. (2022). New secondary metabolites from the marine-derived fungus Talaromyces mangshanicus BTBU20211089. Mar. Drugs, 20.","DOI":"10.3390\/md20020079"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Peng, B., Cai, J., Xiao, Z., Liu, M., Li, X., Yang, B., Fang, W., Huang, Y.Y., Chen, C., and Zhou, X. (2023). Bioactive polyketides and benzene derivatives from two mangrove sediment-derived fungi in the beibu gulf. Mar. Drugs, 21.","DOI":"10.3390\/md21060327"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Youssef, F.S., Ashour, M.L., Singab, A.N.B., and Wink, M.A. (2019). Comprehensive review of bioactive peptides from marine fungi and their biological significance. Mar. Drugs, 17.","DOI":"10.3390\/md17100559"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chen, C.M., Sun, W.G., Liu, X.R., Wei, M.S., Liang, Y., Wang, J.P., Zhu, H.C., and Zhang, Y.H. (2019). Anti-inflammatory spiroaxane and drimane sesquiterpenoids from Talaromyces minioluteus (Penicillium minioluteum). Bioorg. Chem., 91.","DOI":"10.1016\/j.bioorg.2019.103166"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Song, F.H., Dong, Y.F., Wei, S.Z., Zhang, X.W., Zhang, K., and Xu, X.L. (2022). New antibacterial secondary metabolites from a marine-derived Talaromyces sp. Strain BTBU20213036. Antibiotics, 11.","DOI":"10.3390\/antibiotics11020222"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1021\/np200164k","article-title":"Cytotoxic norsesquiterpene peroxides from the endophytic fungus Talaromyces flavus isolated from the mangrove plant Sonneratia apetala","volume":"74","author":"Li","year":"2011","journal-title":"J. Nat. Prod."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Zhang, J., Yang, Z., Liang, Y., Zhong, L., Lin, H., Zhong, B., Li, L., Xu, S., and Liu, Y. (2018). Four new C9 metabolites from the sponge-associated fungus Gliomastix sp. ZSDS1-F7-2. Mar. Drugs, 16.","DOI":"10.3390\/md16070231"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1039\/B801470C","article-title":"Unusually cyclized triterpenes: Occurrence, biosynthesis and chemical synthesis","volume":"26","author":"Domingo","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"ref_15","first-page":"1027","article-title":"Plant triterpenoids with bond-missing skeletons: Biogenesis, distribution and bioactivity","volume":"37","author":"Aldo","year":"2020","journal-title":"Nat. Prod. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"6367","DOI":"10.1002\/chem.202004574","article-title":"seco-Labdanes: A study of terpenoid structural diversity resulting from biosynthetic C\u2013C bond cleavage","volume":"27","author":"Phillip","year":"2021","journal-title":"Chem. Eur. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"5013","DOI":"10.1016\/j.tetlet.2015.07.014","article-title":"Penioxalicin, a novel 3-nor-2,3-seco-labdane type diterpene from the fungus Penicillium oxalicum TW01-1","volume":"56","author":"Bian","year":"2015","journal-title":"Tetrahedron Lett."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1021\/acs.jnatprod.1c00098","article-title":"17-Hydroxybrevianamide N and its N1-methyl derivative, quinazolinones from a soft-coral-derived Aspergillus sp. fungus: 13S enantiomers as the true natural products","volume":"84","author":"Xu","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1021\/acs.jnatprod.0c00804","article-title":"Targeted isolation of asperheptatides from a coral-derived fungus using LC-MS\/MS-Based molecular networking and antitubercular activities of modified cinnamate derivatives","volume":"84","author":"Chao","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Xu, W.F., Mao, N., Xue, X.J., Qi, Y.X., Wei, M.Y., Wang, C.Y., and Shao, C.L. (2019). Structures and absolute configurations of diketopiperazine alkaloids chrysopiperazines A\u2013C from the gorgonian-derived Penicillium chrysogenum fungus. Mar. Drugs, 17.","DOI":"10.3390\/md17050250"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1007\/s42995-021-00103-0","article-title":"Structure modification, antialgal, antiplasmodial, and toxic evaluations of a series of new marine-derived 14-membered resorcylic acid lactone derivatives","volume":"4","author":"Xu","year":"2022","journal-title":"Mar. Life Sci. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3434","DOI":"10.1080\/14786419.2022.2079124","article-title":"Furanone, morpholinone and tetrahydrofuran derivatives from the marine-derived fungus Talaromyces sp. PSU-MF07","volume":"37","author":"Nuansri","year":"2023","journal-title":"Nat. Prod. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"14823","DOI":"10.1039\/C8RA02430H","article-title":"Bioactive terpenoids from Santalum album derived endophytic fungus Fusarium sp. YD-2","volume":"8","author":"Yan","year":"2018","journal-title":"RSC Adv."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1016\/j.bmcl.2015.06.026","article-title":"Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an indonesian ascidian-derived Penicillium verruculosum","volume":"25","author":"Hiroyuki","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref_25","first-page":"207","article-title":"Pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages produced by Penicillium cecidicola FKI-3765-1: II","volume":"62","author":"Hiroyuki","year":"2009","journal-title":"Structure elucidation. J. Antibiot."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1021\/jo981810k","article-title":"Stereochemical determination of acyclic structures based on carbon\u2013proton spin-coupling constants. A method of configuration analysis for natural products","volume":"64","author":"Matsumori","year":"1999","journal-title":"J. Org. Chem."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1021\/acs.jnatprod.4c00015","article-title":"Acremosides A\u2013G, sugar alcohol-conjugated acyclic sesquiterpenes from a sponge-derived Acremonium species","volume":"87","author":"Hao","year":"2024","journal-title":"J. Nat. Prod."},{"key":"ref_28","first-page":"814","article-title":"Two new diterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata","volume":"25","author":"Qi","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1002\/hlca.201400272","article-title":"Paecilomycines A and B, novel diterpenoids, isolated from insect-pathogenic fungi Paecilomyces sp. ACCC 37762","volume":"98","author":"Zhou","year":"2015","journal-title":"Helv. Chim. Acta"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1021\/acs.jnatprod.0c01343","article-title":"Amaurones A\u2013K: Polyketides from the fish gut-derived fungus Amauroascus sp. CMB-F713","volume":"84","author":"Wu","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1021\/acs.jnatprod.6b00013","article-title":"Asnovolins A\u2013G, spiromeroterpenoids isolated from the fungus Aspergillus novofumigatus, and suppression of fibronectin expression by asnovolin E","volume":"79","author":"Ishikawa","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1021\/ol7026834","article-title":"Novofumigatonin, a new orthoester meroterpenoid from Aspergillus novofumigatus","volume":"10","author":"Rank","year":"2008","journal-title":"Org. Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1038\/s41467-018-04983-2","article-title":"Novofumigatonin biosynthesis involves a non-heme iron-dependent endoperoxide isomerase for orthoester formation","volume":"20","author":"Matsuda","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Liu, X.R., Chen, C.M., Zheng, Y.Y., Zhang, M., Tong, Q.Y., Liu, J.J., Zhou, Q., Wang, J.P., Luo, Z.W., and Zhu, H.C. (2018). (\u00b1)-Peniorthoesters A and B, two pairs of novel spiro-orthoester enantiomers with an unusual 1,4,6-trioxaspiro[4.5]decane-7-one unit from Penicillium minioluteum. Front. Chem., 6.","DOI":"10.3389\/fchem.2018.00605"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1021\/acschemneuro.0c00719","article-title":"Viral involvement in alzheimer\u2019s disease","volume":"12","author":"Sait","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1021\/acs.jnatprod.9b00091","article-title":"Cyathane diterpenes from cultures of the bird\u2019s nest fungus cyathus hookeri and their neurotrophic and anti-neuroinflammatory activities","volume":"82","author":"Tang","year":"2019","journal-title":"J. Nat. Prod."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Huang, L.L., Li, Y.X., Pang, J., Lv, L.X., Zhou, J.T., Liang, L.Q., He, X.H., Li, J., Xu, W.F., and Yang, R.Y. (2024). Isolation and characterization of antimicrobial metabolites from the Sophora tonkinensis-associated fungus Penicillium sp. GDGJ-N37. Molecules, 29.","DOI":"10.3390\/molecules29020348"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/wcms.81","article-title":"The ORCA program system","volume":"2","author":"Neese","year":"2012","journal-title":"Wiley Interdiscip. Rev. Comput. Mol. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/chir.20733","article-title":"ECD cotton effect approximated by the Gaussian curve and other methods","volume":"22","author":"Stephens","year":"2010","journal-title":"Chirality"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1107\/S0021889808042726","article-title":"OLEX2: A complete structure solution, refinement and analysis program","volume":"42","author":"Dolomanov","year":"2009","journal-title":"J. Appl. Crystallogr."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1107\/S1600576715005580","article-title":"DSR: Enhanced modelling and refinement of disordered structures with SHELXL","volume":"8","author":"Kratzert","year":"2015","journal-title":"J. Appl. Crystallogr."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Zhu, Y.Z., Deng, L., Dai, X.Y., Song, J.Q., Zhu, Y., Liu, T., Kong, X.L., Zhang, L.J., and Liao, H.B. (2023). Tinopanoids K\u2013T, clerodane diterpenoids with anti-inflammatory activity from Tinospora crispa. Bioorg. Chem., 140.","DOI":"10.1016\/j.bioorg.2023.106812"},{"key":"ref_43","first-page":"3262","article-title":"Three new andrastin derivatives from the endophytic fungus Penicillium vulpinum","volume":"36","author":"Qin","year":"2022","journal-title":"Nat. Prod. Res."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/nprot.2008.141","article-title":"A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing","volume":"3","author":"Pierce","year":"2008","journal-title":"Nat. Protoc."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1021\/acs.jnatprod.6b01016","article-title":"Antimicrobial metabolites from Streptomyces sp. SN0280","volume":"80","author":"Tian","year":"2017","journal-title":"J. Nat. Prod."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/10\/475\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T16:15:50Z","timestamp":1760112950000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/22\/10\/475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,18]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10]]}},"alternative-id":["md22100475"],"URL":"https:\/\/doi.org\/10.3390\/md22100475","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,18]]}}}