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In this paper, five new cembranoid diterpenes, meijicrassolins A\u2013E (1\u20135), were isolated from the soft coral Sarcophyton crassocaule, along with five previously reported compounds (6\u201310). The structures and absolute configuration for new compounds 1\u20135 were assigned by extensive spectroscopic analysis, single-crystal X-ray crystallography, quantum mechanical nuclear magnetic resonance (QM-NMR), and time-dependent density functional theory\/electronic circular dichroism (TDDFT\/ECD) calculations. Compounds 3, 4, and 9 showed moderate inhibition of nitric oxide generation in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Overall, our research results have enriched the library of secondary metabolites from soft corals, providing more molecular entities for subsequent research and development of related compounds.<\/jats:p>","DOI":"10.3390\/md22120536","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T05:02:22Z","timestamp":1732856542000},"page":"536","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cembranoid Diterpenes from South China Sea Soft Coral Sarcophyton crassocaule"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-8569-8934","authenticated-orcid":false,"given":"Hanyang","family":"Peng","sequence":"first","affiliation":[{"name":"Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources & National Key Laboratory for Tropical Crop Breeding, Institute of Tropical Bioscience and Biotechnology, Chinese 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