{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:16:58Z","timestamp":1791245818938,"version":"4.1.0"},"reference-count":27,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T00:00:00Z","timestamp":1732924800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korean government (MSIT)","award":["2021R1C1C1009609"],"award-info":[{"award-number":["2021R1C1C1009609"]}]},{"name":"Korean government (MSIT)","award":["2022R1C1C2003274"],"award-info":[{"award-number":["2022R1C1C2003274"]}]},{"name":"Korean government (MSIT)","award":["2021R1A6C101C369"],"award-info":[{"award-number":["2021R1A6C101C369"]}]},{"name":"Korean government (MSIT)","award":["2022R1A4A3022401"],"award-info":[{"award-number":["2022R1A4A3022401"]}]},{"name":"Korean government (MSIT)","award":["C230430"],"award-info":[{"award-number":["C230430"]}]},{"name":"Korean government (MSIT)","award":["2023-RIS-008"],"award-info":[{"award-number":["2023-RIS-008"]}]},{"name":"Korea Basic Science Institute","award":["2021R1C1C1009609"],"award-info":[{"award-number":["2021R1C1C1009609"]}]},{"name":"Korea Basic Science Institute","award":["2022R1C1C2003274"],"award-info":[{"award-number":["2022R1C1C2003274"]}]},{"name":"Korea Basic Science Institute","award":["2021R1A6C101C369"],"award-info":[{"award-number":["2021R1A6C101C369"]}]},{"name":"Korea Basic Science Institute","award":["2022R1A4A3022401"],"award-info":[{"award-number":["2022R1A4A3022401"]}]},{"name":"Korea Basic Science Institute","award":["C230430"],"award-info":[{"award-number":["C230430"]}]},{"name":"Korea Basic Science Institute","award":["2023-RIS-008"],"award-info":[{"award-number":["2023-RIS-008"]}]},{"name":"Ministry of Education (MOE)","award":["2021R1C1C1009609"],"award-info":[{"award-number":["2021R1C1C1009609"]}]},{"name":"Ministry of Education (MOE)","award":["2022R1C1C2003274"],"award-info":[{"award-number":["2022R1C1C2003274"]}]},{"name":"Ministry of Education (MOE)","award":["2021R1A6C101C369"],"award-info":[{"award-number":["2021R1A6C101C369"]}]},{"name":"Ministry of Education (MOE)","award":["2022R1A4A3022401"],"award-info":[{"award-number":["2022R1A4A3022401"]}]},{"name":"Ministry of Education (MOE)","award":["C230430"],"award-info":[{"award-number":["C230430"]}]},{"name":"Ministry of Education (MOE)","award":["2023-RIS-008"],"award-info":[{"award-number":["2023-RIS-008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>In this study, metagenomic analysis was employed to investigate the bacterial communities in the Muan tidal mudflat of the Republic of Korea. We used metagenomic analysis to identify the microbial community in tidal soil dominated by Proteobacteria. From this environment, the bacterial strain, Saccharomonospora sp. CMS18, was isolated and yielded two previously unknown compounds, penipaline D (3) and N-acetyl-dimethylallyltryptophan (4). The chemical structures of the isolated compounds along with 6-dimethylallyl-indole (1), 6-dimethylallyltryptophan (2), penipaline D (3), and N-acetyl-dimethylallyltryptophan (4) were structurally investigated using HR-ESI-MS and NMR spectroscopy. The isolated compound 6-dimethylallyl-indole (1) demonstrated broad-spectrum antifungal activity, with IC50 value of 0.04 mM against Candida\u00a0glabrata and 0.35 mM against both Candida\u00a0albicans and Cryptococcus\u00a0neoformans. Additionally, it exhibited additive interaction with caspofungin against C. albicans.<\/jats:p>","DOI":"10.3390\/md22120539","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T04:04:04Z","timestamp":1733198644000},"page":"539","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Isolation and Characterization of Bioactive Compounds from Saccharomonospora sp. CMS18 and Their Antifungal Properties"],"prefix":"10.3390","volume":"22","author":[{"given":"Soohyun","family":"Um","sequence":"first","affiliation":[{"name":"College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeongju","family":"Jeong","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Eun","family":"Park","sequence":"additional","affiliation":[{"name":"Korea Research Institute for Veterinary Biologics, Iksan 54531, Republic of Korea"},{"name":"Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongwon","family":"Seo","sequence":"additional","affiliation":[{"name":"Research Institute of Pharmaceutical Sciences, College of Pharmacy, Chonnam National University, Gwangju 61186, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Heon","family":"Jung","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munhyung","family":"Bae","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Gachon University, Incheon 21936, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0068-6220","authenticated-orcid":false,"given":"Kyung-Tae","family":"Lee","sequence":"additional","affiliation":[{"name":"Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1287-3514","authenticated-orcid":false,"given":"Kyuho","family":"Moon","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Kyung Hee University, Seoul 02447, Republic of Korea"},{"name":"Department of Biomedical and Pharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00248-012-0155-2","article-title":"Methyl coenzyme M reductase A (mcrA) gene-based investigation of methanogens in the mudflat sediments of Yangtze River Estuary, China","volume":"66","author":"Zeleke","year":"2013","journal-title":"Microb. 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