{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T03:04:58Z","timestamp":1770347098168,"version":"3.49.0"},"reference-count":95,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["1221633"],"award-info":[{"award-number":["1221633"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"FONDECYT","doi-asserted-by":"publisher","award":["AYV10\/01-22"],"award-info":[{"award-number":["AYV10\/01-22"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Concurso Vicerrector\u00eda de Investigaci\u00f3n y Desarrollo (VID; University of Chile)","award":["1221633"],"award-info":[{"award-number":["1221633"]}]},{"name":"Concurso Vicerrector\u00eda de Investigaci\u00f3n y Desarrollo (VID; University of Chile)","award":["AYV10\/01-22"],"award-info":[{"award-number":["AYV10\/01-22"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>A new antioxidant lipid (AL) was synthesized from rainbow trout (Oncorhynchus mykiss) belly oil and cold-pressed maqui (CPM) (Aristotelia chilensis (Mol.) Stuntz) seed oil via enzymatic interesterification using Thermomyces lanuginosus in supercritical CO2 medium. A Box\u2013Behnken design with 15 experiments was employed, with the independent variables being the following: belly oil\/CPM oil ratio (10\/90, 50\/50, and 90\/10, w\/w), supercritical CO2 temperature (40.0, 50.0, and 60.0 \u00b0C), and supercritical CO2 pressure (100.0, 200.0, and 300.0 bar) for enzymatic interesterification. A multiple optimization was conducted based on the response variables yield and eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and tocopherol contents. The optimized conditions for the AL synthesis were: 81.4\/18.6 (w\/w), 40.0 \u00b0C and 299.99 bar, respectively. The corresponding responses variables were: 77.10% for yield, 5.12 and 4.95 g\u00b7100 g\u22121 total fatty acids for EPA and DHA, respectively, and 217.96, 4.28, 3.48, 64.48, and 6.39 mg\u00b7kg\u22121 oil for \u03b1-tocopherol, \u03b1-tocotrienol, \u03b2-tocopherol, \u03b3-tocopherol, and \u03b4-tocopherol, respectively. A novel AL was successfully synthesized starting from two abundant natural resources commonly considered as by-products during industrial processing. In agreement with the high EPA, DHA, and tocopherol presence, this AL can be recommended to be employed in nutritional and therapeutic supplements, according to its health benefits, particularly concerning antioxidant and anti-inflammatory properties.<\/jats:p>","DOI":"10.3390\/md22120547","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T06:38:25Z","timestamp":1733294305000},"page":"547","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enzymatic Interesterification of Cold-Pressed Maqui (Aristotelia chilensis (Mol.) Stuntz) Seed Oil and Belly Oil from Rainbow Trout (Oncorhynchus mykiss) Through Supercritical CO2"],"prefix":"10.3390","volume":"22","author":[{"given":"Francisca","family":"Reinoso","sequence":"first","affiliation":[{"name":"Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Dr. Carlos Lorca Tobar 964, Santiago 8380494, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2750-2468","authenticated-orcid":false,"given":"Alicia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Dr. Carlos Lorca Tobar 964, Santiago 8380494, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7955-0473","authenticated-orcid":false,"given":"Camila","family":"S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Dr. Carlos Lorca Tobar 964, Santiago 8380494, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjam\u00edn","family":"Claria","sequence":"additional","affiliation":[{"name":"Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Dr. Carlos Lorca Tobar 964, Santiago 8380494, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-5928","authenticated-orcid":false,"given":"Nalda","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Dr. Carlos Lorca Tobar 964, Santiago 8380494, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Medical Technology, Faculty of Medicine, University of Chile, Independencia 1027, Santiago 8380000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Elsa","family":"Pando","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago 8380000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9298-6142","authenticated-orcid":false,"given":"Rodrigo","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine, University of Chile, Independencia 1027, Santiago 8380000, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayana","family":"Apaza","sequence":"additional","affiliation":[{"name":"Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Dr. Carlos Lorca Tobar 964, Santiago 8380494, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0334-3661","authenticated-orcid":false,"given":"Gretel","family":"Dovale-Rosabal","sequence":"additional","affiliation":[{"name":"Department of Food Science and Chemical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Dr. Carlos Lorca Tobar 964, Santiago 8380494, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3136-8137","authenticated-orcid":false,"given":"Santiago P.","family":"Aubourg","sequence":"additional","affiliation":[{"name":"Department of Food Technology, Marine Research Institute (CSIC), Eduardo Cabello 6, 36208 Vigo, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/ejlt.200405001","article-title":"A comprehensive classification system for lipids","volume":"107","author":"Fahy","year":"2005","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1111\/ijfs.13406","article-title":"Optimisation of rancidity stability in long-chain PUFA concentrates obtained from a rainbow trout (Oncorhynchus mykiss) by-product","volume":"52","author":"Rivera","year":"2017","journal-title":"Int. J. Food Sci. Technol."},{"key":"ref_3","unstructured":"Food and Agriculture Organization of the United Nations (FAO)-WHO-FINUT (2010). Fat and Fatty Acids in Human Nutrition. Report of an Expert Consultation, Food and Agriculture Organization of the United Nations (FAO), Ibero-American Nutrition Foundation (FINUT). Post Republished."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1161\/CIR.0000000000000574","article-title":"Seafood long-chain n-3 polyunsaturated fatty acids and cardiovascular disease: A science advisory from the American Heart Association","volume":"138","author":"Rimm","year":"2018","journal-title":"Circulation"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","article-title":"Omega-3 polyunsaturated fatty acids and their health benefits","volume":"9","author":"Shahidi","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(89)90828-3","article-title":"Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and reinfarction trial (DART)","volume":"2","author":"Burr","year":"1989","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/S0140-6736(08)61239-8","article-title":"Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial","volume":"372","year":"2008","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1001\/jama.296.15.1885","article-title":"Fish intake, contaminants, and human health: Evaluating the risks and the benefits","volume":"296","author":"Mozaffarian","year":"2006","journal-title":"JAMA"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/S0140-6736(07)60527-3","article-title":"Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis","volume":"369","author":"Yokoyama","year":"2007","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MCO.0b013e3282f795e6","article-title":"Long-chain omega-3 fatty acid supply in pregnancy and lactation","volume":"11","author":"Cetin","year":"2008","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00075197-200503000-00009","article-title":"N-3 fatty acids and pregnancy outcomes","volume":"8","author":"Decsi","year":"2005","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e472","DOI":"10.1542\/peds.2007-2762","article-title":"Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children\u2019s IQ and body mass index at 7 years of age","volume":"122","author":"Helland","year":"2008","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.foodchem.2003.08.028","article-title":"Comparison of fatty acid composition in some tissues of rainbow trout (Oncorhynchus mykiss) living in seawater and fresh-water","volume":"86","author":"Aras","year":"2004","journal-title":"Food Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/ejlt.200600054","article-title":"Effects of rainbow trout freshness on n-3 polyunsaturated fatty acids in fish offal","volume":"108","author":"Kolakowska","year":"2006","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_15","unstructured":"Servicio Nacional De Aduanas (2024, October 27). Dictamen de Clasificaci\u00f3n N\u00ba 09, de 23 Abril 1998. Available online: https:\/\/www.aduana.cl\/dictamen-de-clasificacion-n-09-de-23-abril-1998\/aduana\/2007-02-27\/175712.html."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0076-6879(81)72003-2","article-title":"Extraction of tissue lipids with a solvent of low toxicity","volume":"Volume 72","author":"Radin","year":"1981","journal-title":"Methods in Enzymology"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s11746-003-0799-5","article-title":"Concentrating PUFA from mackerel processing waste","volume":"80","author":"Zuta","year":"2003","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"ARYEE & SIMPSON (2009). Comparative studies on the yield and quality of solvent-extracted oil from salmon skin. J. Food Eng., 92, 353\u2013358.","DOI":"10.1016\/j.jfoodeng.2008.12.011"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00217-017-3013-0","article-title":"Maximization of the docosahexaenoic and eicosapentaenoic acids content in concentrates obtained from a by-product of rainbow trout (Oncorhynchus mykiss) processing","volume":"244","author":"Pando","year":"2018","journal-title":"Eur. Food Res. Technol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Nollet, L., and Toldr\u00e1, F. (2010). Lipid oxidation. Handbook of Seafood and Seafood Products Analysis, CRC Press.","DOI":"10.1201\/9781420046359"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3844\/ajassp.2010.859.877","article-title":"Fish spoilage mechanisms and preservation: Review","volume":"7","author":"Ghali","year":"2010","journal-title":"Amer. J. Appl. Sci."},{"key":"ref_22","first-page":"421","article-title":"Browning from lipid-protein interactions","volume":"5","year":"1981","journal-title":"Prog. Food Nutr. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF01187514","article-title":"A comparison between conventional and fluorescence detection methods of cooking-induced damage to tuna fish lipids","volume":"200","author":"Aubourg","year":"1995","journal-title":"Z. Lebensm. Unters. Forsch."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Haard, N., and Simpson, B. (2000). Endogenous enzyme activity and seafood quality: Influence of chilling, freezing, and other environmental factors. Seafood Enzymes, Marcel Dekker.","DOI":"10.1201\/9781482289916-19"},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Nollet, L., and Toldr\u00e1, F. (2010). Antioxidants. Handbook of Seafood and Seafood Products Analysis, CRC Press.","DOI":"10.1201\/9781420046359"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Mei, J., Ma, X., and Xie, J. (2019). Review on natural preservatives for extending fish shelf life. Foods, 8.","DOI":"10.3390\/foods8100490"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0308-8146(00)00223-5","article-title":"Natural antioxidants from residual sources","volume":"72","author":"Moure","year":"2001","journal-title":"Food Chem."},{"key":"ref_28","first-page":"107","article-title":"Nonenzymatic antioxidant defense systems","volume":"Volume 4","author":"Frei","year":"1994","journal-title":"Natural Antioxidants in Human Health and Diseases"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"111036","DOI":"10.1016\/j.fct.2019.111036","article-title":"Chemoprotective and antiobesity effects of tocopherols from seed oil of Maqui berry: Their antioxidative and digestive enzyme inhibition potential","volume":"136","author":"Monterrosa","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.17660\/th2019\/74.5.2","article-title":"Maqui (Aristotelia chilensis [Molina] Stuntz): The most antioxidant wild berry towards agricultural production","volume":"74","author":"Preller","year":"2019","journal-title":"Fruits"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.foodchem.2007.08.092","article-title":"Antioxidant and cardioprotective activities of phenolic extracts from fruits of Chilean blackberry Aristotelia chilensis (Elaeocarpaceae), Maqui","volume":"107","year":"2008","journal-title":"Food Chem."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.fct.2016.12.036","article-title":"The chilean superfruit blackberry Aristotelia chilensis (Elaeocarpaceae), Maqui as mediator in inflammation-associated disorders","volume":"108","author":"Cespedes","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jfca.2017.01.003","article-title":"Characterization of anthocyanins in novel Chilean maqui berry clones by HPLC\u2013DAD\u2013ESI\/MSn and NMR-spectroscopy","volume":"58","author":"Brauch","year":"2017","journal-title":"J. Food Compos. Anal."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s11130-019-00746-6","article-title":"A Review of the Potential of Chilean Native Berries in the Treatment of Obesity and its Related Features","volume":"74","author":"Jimenez","year":"2019","journal-title":"Plant Foods Hum. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"7542","DOI":"10.1021\/jf025797n","article-title":"Juice and Phenolic Fractions of the Berry Aristotelia chilensis Inhibit LDL Oxidation in Vitro and Protect Human Endothelial Cells against Oxidative Stress","volume":"50","author":"Aspillaga","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"ref_36","first-page":"11","article-title":"Aristotelia chilensis, rutin and quercetin amielorates acute vascular endothelial dysfunction in rat thoracic aorta exposed to oxidative stress","volume":"14","author":"Fuentes","year":"2015","journal-title":"Bol. Latinoam. Caribe Plantas Med."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1039\/C8FO02429D","article-title":"A comprehensive review on fruit Aristotelia chilensis (Maqui) for modern health: Towards a better understanding","volume":"10","author":"Masoodi","year":"2019","journal-title":"Food Funct."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.bbalip.2018.08.004","article-title":"Intake of stigmasterol and \u03b2-sitosterol alters lipid metabolism and alleviates NAFLD in mice fed a high-fat western-style diet","volume":"1863","author":"Feng","year":"2018","journal-title":"Biochim. Et Biophys. Acta-Mol. Cell Bioll"},{"key":"ref_39","first-page":"582","article-title":"Phytosterols Suppress Phagocytosis and Inhibit Inflammatory Mediators via ERK Pathway on LPS-Triggered Inflammatory Responses in RAW264","volume":"8","author":"Yuan","year":"2019","journal-title":"7 Macrophages and the Correlation with Their Structure. Foods"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0003-9861(83)90145-5","article-title":"Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?","volume":"221","author":"Burton","year":"1983","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.redox.2014.02.002","article-title":"Regulatory metabolites of vitamin E and their putative relevance for atherogenesis","volume":"2","author":"Wallert","year":"2014","journal-title":"Redox. Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/carcin\/bgp205","article-title":"Cancer-preventive activities of tocopherols and tocotrienols","volume":"31","author":"Ju","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3614","DOI":"10.1111\/1750-3841.14963","article-title":"Study on Antioxidant Activity of Amino Acids at Frying Temperatures and Their Interaction with Rosemary Extract, Green Tea Extract, and Ascorbic Acid","volume":"84","author":"Hwang","year":"2019","journal-title":"J. Food Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s11746-006-1181-3","article-title":"Lipase-catalyzed transesterification of trilinolein or trilinolenin with selected phenolic acids","volume":"83","author":"Sabally","year":"2006","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_45","unstructured":"Hoboken, N.J. (2005). Bailey\u2019s Industrial Oil & Fats Products, John Wiley & Sons. [6th ed.]."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Akoh, C., and Pande, G. (2020). Structured Lipids and Health. Bailey\u2019s Industrial Oil and Fat Products, John Wiley & Sons.","DOI":"10.1002\/047167849X.bio085"},{"key":"ref_47","first-page":"150","article-title":"Enzymatic interesterification","volume":"15","author":"Cowan","year":"2004","journal-title":"Process advantage and product benefits inform Edible Appl. Technol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1271\/bbb.56.324","article-title":"Comparison of the Antioxidative Activity of Some Acid-phenols: Structure-Activity Relationship","volume":"56","author":"Cuvelier","year":"1992","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1007\/s11746-006-5012-3","article-title":"Enzymatic glycerolysis and transesterification of vegetable oil for enhanced production of feruloylated glycerols","volume":"83","author":"Laszlo","year":"2006","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_50","first-page":"11","article-title":"Current trends and future perspectives on omega-3 fatty acids","volume":"5","author":"Ofosu","year":"2017","journal-title":"RRJOB"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3390\/life4030331","article-title":"Supercritical carbon dioxide and its potential as a life-sustaining solvent in a planetary environment","volume":"4","author":"Budisa","year":"2014","journal-title":"Life"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"105645","DOI":"10.1016\/j.supflu.2022.105645","article-title":"Production of biopharmaceutical dried-powders using supercritical CO2 technology","volume":"187","author":"Ryan","year":"2022","journal-title":"J. Supercrit. Fluids"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"150166","DOI":"10.1016\/j.cej.2024.150166","article-title":"State-of-the-art conceptual design of supercritical carbon dioxide as a green technology involved in bioresource conversion processes","volume":"486","author":"Yan","year":"2024","journal-title":"Chem. Eng. J."},{"key":"ref_54","unstructured":"Luque de Castro, M.D., Valc\u00e1rcel, M., and Cases, M.V. (1993). Extracci\u00f3n Fluidos Supercr\u00edticos Proceso Anal\u00edtico, Revert\u00e9."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1080\/10916460008949872","article-title":"Recovery of asphaltenes from tar sand by supercritical fluid extraction","volume":"18","author":"Demirbas","year":"2000","journal-title":"Pet. Sci. Technol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0001-8686(97)90021-X","article-title":"Supercritical fluids: An interesting medium for chemical and biochemical processes","volume":"71","author":"Ikushima","year":"1997","journal-title":"Adv. Colloid. Interface Sci."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.biortech.2014.01.021","article-title":"Application of response surface methodology and artificial neural network methods in modelling and optimization of biosorption process","volume":"160","author":"Chojnacka","year":"2014","journal-title":"Bioresour. Technol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"111621","DOI":"10.1016\/j.foodres.2022.111621","article-title":"A unifying approach to lipid oxidation in emulsions: Modelling and experimental validation","volume":"160","year":"2022","journal-title":"Food Res. Int."},{"key":"ref_59","unstructured":"American Oil Chemists\u2019 Society (AOCS) (1993). Official Methods and Recommended Practices of the AOCS, AOCS. [4th ed.]. Official Methods Aa 4-38,Ca 5a-40, Cd 8b-90, Cd 18-90, Cg 3-91, Ti; 1a-64, Cc 13e-92, Ce 8-89."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/ijms11010233","article-title":"A review on the effects of supercritical carbon dioxide on enzyme activity","volume":"11","author":"Wimmer","year":"2010","journal-title":"Int. J. Mol. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0141-0229(98)00164-1","article-title":"A study of hydrolases stability in supercritical carbon dioxide (SC-CO2)","volume":"24","author":"Giessauf","year":"1999","journal-title":"Enzym. Microb. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00217-020-03643-4","article-title":"Acylglycerol synthesis including EPA and DHA from rainbow trout (Oncorhynchus mykiss) belly flap oil and caprylic acid catalyzed by Thermomyces lanuginosus lipase under supercritical carbon dioxide","volume":"247","author":"Pando","year":"2021","journal-title":"Eur. Food Res. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Dovale-Rosabal, G., Espinosa, A., Rodr\u00edguez, A., Barriga, A., Palomino-Calder\u00f3n, A., Romero, N., Troncoso, R.H., and Aubourg, S.P. (2022). Effect of structured phenolic lipids with EPA\/DHA and gallic acid against metabolic-associated fatty liver disease (MAFLD) in mice. Molecules, 27.","DOI":"10.3390\/molecules27227702"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez, C., Rodr\u00edguez, A., Reinoso, F., Dovale-Rosabal, G., Romero, N., Espinosa, A., Pando, M.E., Claria, B., Valenzuela, R., and Char, C. (2024). Optimization of Oil and Tocopherol Extraction from Maqui (Aristotelia chilensis (Mol.) Stuntz) by Supercritical CO2 Procedure. Antioxidants, 13.","DOI":"10.3390\/antiox13070845"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s12393-023-09343-5","article-title":"Solubility of food-relevant substances in pure and modified supercritical carbon dioxide: Experimental data (2011\u2013Present), modeling, and related applications","volume":"15","author":"Dias","year":"2023","journal-title":"Food Eng. Rev."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.foodchem.2006.08.037","article-title":"Lipase-catalysed acylglycerol synthesis of glycerol and n \u2212 3 PUFA from tuna oil: Optimisation of process parameters","volume":"103","author":"Liu","year":"2007","journal-title":"Food Chem."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.apm.2011.07.067","article-title":"Optimization of probabilistic multiple response surfaces","volume":"36","author":"Hejazi","year":"2012","journal-title":"Appl. Math. Model."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.talanta.2014.01.034","article-title":"Experimental design and multiple response optimization. Using the desirability function in analytical methods development","volume":"124","author":"Candioti","year":"2014","journal-title":"Talanta"},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Fajdek-Bieda, A. (2023). Optimization of the Geraniol Transformation Process in the Presence of Natural Mineral Diatomite as a Catalyst. Catalysts, 13.","DOI":"10.3390\/catal13040777"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1556\/AMicr.55.2008.3.1","article-title":"Microbial lipases: At the interface of aqueous and nonaqueous media\u2014A review","volume":"55","author":"Verma","year":"2008","journal-title":"Acta Microbiol. Immunol. Hung."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10529-008-9823-1","article-title":"Wheat germ lipase catalyzed kinetic resolution of secondary alcohols in non-aqueous media","volume":"31","author":"Xia","year":"2009","journal-title":"Biotechnol. Lett."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.bej.2003.12.004","article-title":"Enzyme-catalyzed optical resolution of mandelic acid via RS(\u2212\/+)-methyl mandelate in non-aqueous media Source","volume":"19","author":"Yadav","year":"2004","journal-title":"Biochem. Eng. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3989\/gya.010710","article-title":"Physico-chemical properties of blends of palm olein with other vegetable oils","volume":"61","author":"Siddique","year":"2010","journal-title":"Grasas Y Aceites"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Talebi, S.M., Darbandi, N., Naziri, F., and Matsyura, A. (2024). Seed morphometry and fatty acid profile in oilseed and non-oilseed sunflower cultivars. Biochem. Syst. Ecol., 113.","DOI":"10.1016\/j.bse.2024.104805"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jfoodeng.2008.03.007","article-title":"Thermal and rheological properties and the effects of temperature on the viscosity and oxidation rate of unpurified salmon oil","volume":"89","author":"Huang","year":"2008","journal-title":"J. Food Eng."},{"key":"ref_76","doi-asserted-by":"crossref","unstructured":"Broadhurst, C.L., Schmidt, W.F., Qin, J., Chao, K., and Kim, M.S. (2018). Continuous gradient temperature Raman spectroscopy of fish oils provides detailed vibrational analysis and rapid, nondestructive graphical product authentication. Molecules, 23.","DOI":"10.3390\/molecules23123293"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11746-005-1057-6","article-title":"Thermal and flow properties of oils from salmon heads","volume":"82","author":"Sathivel","year":"2005","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ejlt.200900173","article-title":"Effect of high-pressure treatment on microbial activity and lipid oxidation in chilled coho salmon","volume":"112","author":"Aubourg","year":"2010","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_79","unstructured":"Ministerio de Salud MINSAL (2024, September 09). Reglamento Sanitario de los Alimentos DTO. N\u25e6 977\/96. ChileAlimentos., Available online: https:\/\/dinta.cl\/wp-content\/uploads\/2024\/06\/DECRETO_977_96_actualizado_-mayo-2024_DINTA.pdf."},{"key":"ref_80","first-page":"93","article-title":"Analytical investigation of oxidative deterioration of sunflower oil stored under different conditions","volume":"3","author":"Raza","year":"2009","journal-title":"Biharean Biol."},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Decker, E.A., Elias, R.J., and McClements, D.J. (2010). Oxidation in foods and beverages and antioxidant applications. Oxidation of Edible Oils, Woodhead Publishing.","DOI":"10.1533\/9780857090331"},{"key":"ref_82","unstructured":"CODEX Alimentarius (2017, January 17\u201321). Codex Draft Standard for Fish Oil. Proceedings of the 40th Session of the Codex Alimentarius Committee (CAC40), Geneva, Switzerland."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3989\/gya.096908","article-title":"Relationship between changes in peroxide value and conjugated dienes during oxidation of sunflower oils with different degrees of unsaturation","volume":"60","author":"Marmesat","year":"2009","journal-title":"Grasas Y Aceites"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Dovale-Rosabal, G., Rodr\u00edguez, A., Espinosa, A., Barriga, A., and Aubourg, S.P. (2021). Synthesis of EPA-and DHA-enriched structured acylglycerols at the sn-2 position starting from commercial salmon oil by enzymatic lipase catalysis under supercritical conditions. Molecules, 26.","DOI":"10.3390\/molecules26113094"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"35183","DOI":"10.1021\/acsomega.3c04634","article-title":"Stabilization of the antioxidant properties in spray-dried microcapsules of fish and chia oil blends","volume":"8","author":"Rahim","year":"2023","journal-title":"ACS Omega"},{"key":"ref_86","unstructured":"Sapkota, B. Effects of Dichlorvos on Freshwater Fish Rohu (Labeo rohita Hamilton, 1822). [Master\u2019s Thesis, University of Tribhuvan]."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1021\/jf048615t","article-title":"Fatty acid composition and antioxidant properties of cold-pressed marionberry, boysenberry, red raspberry, and blueberry seed oils","volume":"53","author":"Parry","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/ejlt.201300239","article-title":"Lipid and sensory quality of canned Atlantic salmon (Salmo salar): Effect of the use of different seaweed extracts as covering liquids","volume":"116","author":"Ortiz","year":"2014","journal-title":"Eur. J. Lipid Sci. Technol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1365-2621.1994.tb06942.x","article-title":"Tocopherol deposition in the muscle of Atlantic salmon (Salmo salar)","volume":"59","author":"Sigurgisladottlr","year":"1994","journal-title":"J. Food Sci."},{"key":"ref_90","unstructured":"Myers, R.H., and Montgomery, D.C. (1995). Response Surface Methodology: Process and Product Optimization Using Design Experiments, John Wiley & Sons, Inc."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2307\/1266632","article-title":"A review of response surface methodology: A literature survey","volume":"8","author":"Hill","year":"1966","journal-title":"Technometrics"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jfoodeng.2005.01.020","article-title":"Concentration of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) of tuna oil by urea complexation: Optimization of process parameters","volume":"73","author":"Liu","year":"2006","journal-title":"J. Food Eng."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s11746-001-0280-5","article-title":"Interesterification of tallow and sunflower oil","volume":"78","author":"Castro","year":"2001","journal-title":"J. Am. Oil Chem. Soc."},{"key":"ref_94","doi-asserted-by":"crossref","unstructured":"Paquot, C., and Hautfenne, A. (1986). IUPAC Standard Methods for the Analysis of Oils, Fats and Derivatives, Blackwell Scientific. [7th ed.].","DOI":"10.1016\/S0003-2670(00)85376-3"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.foodchem.2017.09.130","article-title":"Effect of the composition of extra virgin olive oils on the differentiation and antioxidant capacities of twelve monovarietals","volume":"243","author":"Fuentes","year":"2018","journal-title":"Food Chem. Sci. 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