{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:08:32Z","timestamp":1790798912259,"version":"4.1.0"},"reference-count":125,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"The National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00274576"],"award-info":[{"award-number":["RS-2023-00274576"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"The National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2021-NR060118"],"award-info":[{"award-number":["RS-2021-NR060118"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"The National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2022-NR072275"],"award-info":[{"award-number":["RS-2022-NR072275"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["RS-2023-00274576"],"award-info":[{"award-number":["RS-2023-00274576"]}]},{"name":"The Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["RS-2021-NR060118"],"award-info":[{"award-number":["RS-2021-NR060118"]}]},{"name":"The Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education","award":["RS-2022-NR072275"],"award-info":[{"award-number":["RS-2022-NR072275"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by severe pruritus and recurrent flare-ups, significantly impacting patients\u2019 quality of life. Current treatments, such as corticosteroids and immunomodulators, often provide symptomatic relief but can lead to adverse effects with prolonged use. Seaweed, a sustainable and nutrient-dense resource, has emerged as a promising alternative due to its rich bioactive compounds\u2014polysaccharides, phlorotannins, polyphenols, and chlorophyll\u2014that offer anti-inflammatory, antioxidant, and immunomodulatory properties. This review explores the therapeutic potential of brown, red, and green algae in alleviating AD symptoms, highlighting the effects of specific species, including Undaria pinnatifida, Laminaria japonica, Chlorella vulgaris, and Sargassum horneri. These seaweeds modulate immune responses, reduce epidermal thickness, and restore skin barrier function, presenting a novel, safe, and effective approach to AD management. Further clinical studies are needed to confirm their efficacy and establish dosing strategies, paving the way for seaweed-derived therapies as natural alternatives in AD treatment.<\/jats:p>","DOI":"10.3390\/md22120566","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T03:40:56Z","timestamp":1734493256000},"page":"566","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The Beneficial Roles of Seaweed in Atopic Dermatitis"],"prefix":"10.3390","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-5878-1201","authenticated-orcid":false,"given":"Ah-Reum","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myeong-Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"Korean Medicine (KM)\u2014Application Center, Korea Institute of Oriental Medicine, Daegu 41062, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaeseong","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6274-4257","authenticated-orcid":false,"given":"Kyoung Mi","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonggi","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea"},{"name":"Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea"},{"name":"Marine Integrated Biomedical Technology Center, The National Key Research Institutes, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,12,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.clindermatol.2018.05.007","article-title":"Epidemiology of adult atopic dermatitis","volume":"36","author":"Sacotte","year":"2018","journal-title":"Clin. 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