{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T22:01:30Z","timestamp":1774476090351,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key R&amp;D Program of Shandong Province, China","award":["2024CXPT029"],"award-info":[{"award-number":["2024CXPT029"]}]},{"name":"Key R&amp;D Program of Shandong Province, China","award":["82404502"],"award-info":[{"award-number":["82404502"]}]},{"name":"Key R&amp;D Program of Shandong Province, China","award":["82304375"],"award-info":[{"award-number":["82304375"]}]},{"name":"Key R&amp;D Program of Shandong Province, China","award":["SYS202205"],"award-info":[{"award-number":["SYS202205"]}]},{"name":"Key R&amp;D Program of Shandong Province, China","award":["CATASCXTD202416"],"award-info":[{"award-number":["CATASCXTD202416"]}]},{"name":"National Natural Science Foundation of China","award":["2024CXPT029"],"award-info":[{"award-number":["2024CXPT029"]}]},{"name":"National Natural Science Foundation of China","award":["82404502"],"award-info":[{"award-number":["82404502"]}]},{"name":"National Natural Science Foundation of China","award":["82304375"],"award-info":[{"award-number":["82304375"]}]},{"name":"National Natural Science Foundation of China","award":["SYS202205"],"award-info":[{"award-number":["SYS202205"]}]},{"name":"National Natural Science Foundation of China","award":["CATASCXTD202416"],"award-info":[{"award-number":["CATASCXTD202416"]}]},{"name":"Shandong Laboratory Program","award":["2024CXPT029"],"award-info":[{"award-number":["2024CXPT029"]}]},{"name":"Shandong Laboratory Program","award":["82404502"],"award-info":[{"award-number":["82404502"]}]},{"name":"Shandong Laboratory Program","award":["82304375"],"award-info":[{"award-number":["82304375"]}]},{"name":"Shandong Laboratory Program","award":["SYS202205"],"award-info":[{"award-number":["SYS202205"]}]},{"name":"Shandong Laboratory Program","award":["CATASCXTD202416"],"award-info":[{"award-number":["CATASCXTD202416"]}]},{"name":"Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center","award":["2024CXPT029"],"award-info":[{"award-number":["2024CXPT029"]}]},{"name":"Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center","award":["82404502"],"award-info":[{"award-number":["82404502"]}]},{"name":"Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center","award":["82304375"],"award-info":[{"award-number":["82304375"]}]},{"name":"Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center","award":["SYS202205"],"award-info":[{"award-number":["SYS202205"]}]},{"name":"Chinese Academy of Tropical Agricultural Sciences for Science and Technology Innovation Team of National Tropical Agricultural Science Center","award":["CATASCXTD202416"],"award-info":[{"award-number":["CATASCXTD202416"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>A chemical investigation of the soft coral Lobophytum sp. and the sponge Xestospongia sp. from the South China Sea led to the isolation of five steroids, including two new compounds (1 and 4) and one known natural product (3). Compounds 1\u20133 were derived from the soft coral Lobophytum sp., while 4 and 5 were obtained from the sponge Xestospongia sp. The structures of these compounds were determined by extensive spectroscopic analysis, the time-dependent density functional theory\u2013electronic circular dichroism (TDDFT-ECD) calculation method, and comparison with the spectral data previously reported in the literature. The antibacterial and anti-inflammatory activities of isolated compounds were evaluated in vitro. Compounds 1\u20133, 4, and 5 exhibited weak antibacterial activity against vancomycin-resistant Enterococcus faecium G1, Streptococcus parauberis KSP28, Photobacterium damselae FP2244, Lactococcus garvieae FP5245, and Pseudomonas aeruginosa ZJ028. Moreover, compound 3 showed significant anti-inflammatory activity by inhibiting lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells, with an IC50 value of 13.48 \u03bcM.<\/jats:p>","DOI":"10.3390\/md23010036","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:42:15Z","timestamp":1736750535000},"page":"36","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Bioactive Steroids with Structural Diversity from the South China Sea Soft Coral Lobophytum sp. and Sponge Xestospongia sp."],"prefix":"10.3390","volume":"23","author":[{"given":"Lin-Mao","family":"Ke","sequence":"first","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"},{"name":"Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"},{"name":"Ocean College of Hebei Agricultural University, Qinhuangdao 066000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9828-7431","authenticated-orcid":false,"given":"Song-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Shanghai University, Shanghai 200444, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8992-4151","authenticated-orcid":false,"given":"Yan-Bo","family":"Zeng","sequence":"additional","affiliation":[{"name":"Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-Resources, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8805-3963","authenticated-orcid":false,"given":"Ming-Zhi","family":"Su","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-2070","authenticated-orcid":false,"given":"Yue-Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"},{"name":"School of Medicine, Shanghai University, Shanghai 200444, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Rodrigues, I.G., Miguel, M.G., and Mnif, W. 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