{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:31:03Z","timestamp":1792092663307,"version":"4.4.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T00:00:00Z","timestamp":1736985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00e3o Paulo Research Foundation (FAPESP), Brasil","award":["2021\/02974-9"],"award-info":[{"award-number":["2021\/02974-9"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP), Brasil","award":["2023\/13928-3"],"award-info":[{"award-number":["2023\/13928-3"]}]},{"name":"S\u00e3o Paulo Research Foundation (FAPESP), Brasil","award":["2019\/19708-0"],"award-info":[{"award-number":["2019\/19708-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The rise in multidrug-resistant (MDR) bacteria has prompted extensive research into antibacterial compounds, as these resistant strains compromise current treatments. This resistance leads to prolonged hospitalization, increased mortality rates, and higher healthcare costs. To address this challenge, the pharmaceutical industry is increasingly exploring natural products, particularly those of marine origin, as promising candidates for antimicrobial drugs. Marine sponges, in particular, are of interest because of their production of secondary metabolites (SM), which serve as chemical defenses against predators and pathogens. These metabolites exhibit a wide range of therapeutic properties, including antibacterial activity. This systematic review examines recent advancements in identifying new sponge-derived compounds with antimicrobial activity, specifically targeting Pseudomonas aeruginosa, a prevalent Gram-negative pathogen with the highest incidence rates in clinical settings. The selection criteria focused on antimicrobial compounds with reported Minimum Inhibitory Concentration (MIC) values. The identified SM include alkaloids, sesterterpenoids, nitrogenous diterpene, and bromotyrosine-derived derivatives. The structural features of the active compounds selected in this review may provide a foundational framework for developing new, highly bioactive antimicrobial agents.<\/jats:p>","DOI":"10.3390\/md23010043","type":"journal-article","created":{"date-parts":[[2025,1,16]],"date-time":"2025-01-16T06:46:10Z","timestamp":1737009970000},"page":"43","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Exploring Antibacterial Properties of Marine Sponge-Derived Natural Compounds: A Systematic Review"],"prefix":"10.3390","volume":"23","author":[{"given":"Cintia Cristina","family":"Santi Martignago","sequence":"first","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"},{"name":"Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, Switzerland"},{"name":"School of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"de Souza Barbosa","sequence":"additional","affiliation":[{"name":"Department of Microbiology Immunobiology and Parasitology, Paulist School of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04023-062, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homero","family":"Garcia Motta","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Soares-Silva","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Paloma","family":"Maso Lopes Peres","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lais Caroline","family":"Souza e Silva","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian","family":"Bonif\u00e1cio","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolyne","family":"dos Santos Jorge Sousa","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4902-513X","authenticated-orcid":false,"given":"Amanda","family":"Sardeli Alqualo","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4325-0638","authenticated-orcid":false,"given":"J\u00falia","family":"Parisi","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Metropolitan University of Santos (UNIMES), Santos 11045-001, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3752-2198","authenticated-orcid":false,"given":"Olivier","family":"Jordan","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, Switzerland"},{"name":"School of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Claudia","family":"Muniz Renno","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Federal University of S\u00e3o Paulo, Santos 11015-020, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Caroline Campos","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Immunobiology and Parasitology, Paulist School of Medicine, Federal University of S\u00e3o Paulo, S\u00e3o Paulo 04023-062, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3906-2041","authenticated-orcid":false,"given":"Viorica","family":"Patrulea","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Sciences of Western Switzerland (ISPSO), University of Geneva, 1206 Geneva, Switzerland"},{"name":"School of Pharmaceutical Sciences, University of Geneva, 1206 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Muteeb, G., Rehman, M.T., Shahwan, M., and Aatif, M. 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