{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T06:40:57Z","timestamp":1771828857767,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland (SFI) and the Marine Institute","doi-asserted-by":"publisher","award":["SFI\/15\/1A\/3100"],"award-info":[{"award-number":["SFI\/15\/1A\/3100"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland (SFI) and the Marine Institute","doi-asserted-by":"publisher","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland (SFI) and the Marine Institute","doi-asserted-by":"publisher","award":["R21 AT010939"],"award-info":[{"award-number":["R21 AT010939"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland (SFI) and the Marine Institute","doi-asserted-by":"publisher","award":["R56 AI154922"],"award-info":[{"award-number":["R56 AI154922"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland (SFI) and the Marine Institute","doi-asserted-by":"publisher","award":["CE16006"],"award-info":[{"award-number":["CE16006"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Regional Development Fund","award":["SFI\/15\/1A\/3100"],"award-info":[{"award-number":["SFI\/15\/1A\/3100"]}]},{"name":"European Regional Development Fund","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}]},{"name":"European Regional Development Fund","award":["R21 AT010939"],"award-info":[{"award-number":["R21 AT010939"]}]},{"name":"European Regional Development Fund","award":["R56 AI154922"],"award-info":[{"award-number":["R56 AI154922"]}]},{"name":"European Regional Development Fund","award":["CE16006"],"award-info":[{"award-number":["CE16006"]}]},{"name":"US National Institutes of Health","award":["SFI\/15\/1A\/3100"],"award-info":[{"award-number":["SFI\/15\/1A\/3100"]}]},{"name":"US National Institutes of Health","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}]},{"name":"US National Institutes of Health","award":["R21 AT010939"],"award-info":[{"award-number":["R21 AT010939"]}]},{"name":"US National Institutes of Health","award":["R56 AI154922"],"award-info":[{"award-number":["R56 AI154922"]}]},{"name":"US National Institutes of Health","award":["CE16006"],"award-info":[{"award-number":["CE16006"]}]},{"name":"Irish National Shiptime Programme","award":["SFI\/15\/1A\/3100"],"award-info":[{"award-number":["SFI\/15\/1A\/3100"]}]},{"name":"Irish National Shiptime Programme","award":["2014-2020"],"award-info":[{"award-number":["2014-2020"]}]},{"name":"Irish National Shiptime Programme","award":["R21 AT010939"],"award-info":[{"award-number":["R21 AT010939"]}]},{"name":"Irish National Shiptime Programme","award":["R56 AI154922"],"award-info":[{"award-number":["R56 AI154922"]}]},{"name":"Irish National Shiptime Programme","award":["CE16006"],"award-info":[{"award-number":["CE16006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>New technology has opened opportunities for research and exploration of deep-water ecosystems, highlighting deep-sea coral reefs as a rich source of novel bioactive natural products. During our ongoing investigation of the chemodiversity of the Irish deep sea and the soft coral Anthothela grandiflora, we report 12 unreported cadinene-like functionalized sesquiterpenes, anthoteibinenes F\u2013Q. The metabolites were isolated using both bioassay- and 1H NMR-guided approaches. One-\/two-dimensional NMR spectroscopy and high-resolution mass spectrometry were used for structure elucidation, while a combination of NOESY NMR experiments, GIAO NMR calculations coupled with DP4+ probabilities measures, and ECD comparisons were incorporated to propose relative and absolute configurations of the anthoteibinenes. The metabolites were screened against the Respiratory Syncytial Virus (RSV), ESKAPE pathogens, five Candida albicans strains, and one strain of C. auris.<\/jats:p>","DOI":"10.3390\/md23010044","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T11:24:56Z","timestamp":1737113096000},"page":"44","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anthoteibinenes F\u2013Q: New Sesquiterpenes from the Irish Deep-Sea Coral Anthothela grandiflora"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4621-6291","authenticated-orcid":false,"given":"Stine S. H.","family":"Olsen","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0479-8032","authenticated-orcid":false,"given":"Sam","family":"Afoullouss","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ezequiel","family":"Cruz Rosa","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of South Florida, 4202 E. Fowler Avenue, CHE205, Tampa, FL 33620, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryan M.","family":"Young","sequence":"additional","affiliation":[{"name":"School of Natural Sciences and Ryan Institute, University of Galway, University Road, H91TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Johnson","sequence":"additional","affiliation":[{"name":"School of Natural Sciences and Ryan Institute, University of Galway, University Road, H91TK33 Galway, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4806-0040","authenticated-orcid":false,"given":"A. 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