{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:27:22Z","timestamp":1772670442885,"version":"3.50.1"},"reference-count":47,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries, Korea","doi-asserted-by":"publisher","award":["20220560"],"award-info":[{"award-number":["20220560"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003566","name":"Ministry of Oceans and Fisheries, Korea","doi-asserted-by":"publisher","award":["NRF-RS-2023-00208880"],"award-info":[{"award-number":["NRF-RS-2023-00208880"]}],"id":[{"id":"10.13039\/501100003566","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["20220560"],"award-info":[{"award-number":["20220560"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"Ministry of Science and ICT","doi-asserted-by":"publisher","award":["NRF-RS-2023-00208880"],"award-info":[{"award-number":["NRF-RS-2023-00208880"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Ishige okamurae (I. okamuare), an edible brown alga, is rich in isophloroglucin A (IPA) phlorotannin compounds and is effective in preventing diseases, including diabetes. We evaluated its anti-glycation ability, intracellular reactive oxygen species scavenging activity, inhibitory effect on the accumulation of intracellular MGO\/MGO-derived advanced glycation end products (AGE), and regulation of downstream signaling pathways related to the AGE\u2013receptor for AGEs (RAGE) interaction. IPA (0.2, 1, and 5 \u03bcM) demonstrated anti-glycation ability by inhibiting the formation of glucose-fructose-BSA-derived AGEs by up to 54.63% compared to the untreated control, reducing the formation of irreversible cross-links between MGO-derived AGEs and collagen by 67.68% and the breaking down of existing cross-links by approximately 91% (p &lt; 0.001). IPA protected cells from MGO-induced oxidative stress by inhibiting intracellular MGO accumulation (untreated cells: 1.62 \u03bcg\/mL, MGO treated cells: 25.27 \u03bcg\/mL, and IPA 5 \u03bcM: 11.23 \u03bcg\/mL) (p &lt; 0.001) and AGE generation and inhibited MGO-induced renal cell damage via the downregulation of MGO-induced RAGE protein expression (relative protein expression levels of MGO treated cells: 9.37 and IPA 5 \u03bcM:1.74) (p &lt; 0.001). Overall, these results suggest that IPA has the potential to be utilized as a useful natural agent for the prevention and management of AGE-related diabetic nephropathy, owing to its strong anti-glycation activity.<\/jats:p>","DOI":"10.3390\/md23010048","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T10:32:15Z","timestamp":1737369135000},"page":"48","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ishophloroglucin A Isolated from Ishige okamurae Protects Glomerular Cells from Methylglyoxal-Induced Diacarbonyl Stress and Inhibits the Pathogenesis of Diabetic Nephropathy"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-3209","authenticated-orcid":false,"given":"Chi-Heung","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-5714","authenticated-orcid":false,"given":"Min-Gyeong","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea"},{"name":"Department of Food Biotechnology, University of Science and Technology, Daejeon 34113, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5797-500X","authenticated-orcid":false,"given":"Bomi","family":"Ryu","sequence":"additional","affiliation":[{"name":"Major of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-4213","authenticated-orcid":false,"given":"Sang-Hoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Functional Food Research, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea"},{"name":"Department of Food Biotechnology, University of Science and Technology, Daejeon 34113, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.kint.2017.11.034","article-title":"Advanced glycation end products in the pathogenesis of chronic kidney disease","volume":"93","author":"Rabbani","year":"2018","journal-title":"Kidney Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1365-2796.2002.00932.x","article-title":"Diabetes and advanced glycation endproducts","volume":"251","author":"Vlassara","year":"2002","journal-title":"J. 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