{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T22:08:17Z","timestamp":1783462097758,"version":"3.55.0"},"reference-count":81,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Fishes of the genus Pterois possess spines that provoke intense pain, which can last for weeks. Since the first toxicological description of their spine venom, a significant amount of research has been published regarding their biochemical characterization. This minireview presents research published from 1959 to 2024 on bioactive substances found in Pterois species. Pterois venom mainly contains peptides and proteins that display a range of biological activities, including anticancer, antimicrobial, antioxidant, antiviral, enzymatic, cardiovascular, procoagulant, neurological, neuromuscular, and nutraceutical effects. Although Pterois venom contains bioactive substances, the toxic side effects, such as hemolysis and nociception, of these venoms should be considered. Hence, further intense research is needed to establish the potential uses of Pterois venom for human health.<\/jats:p>","DOI":"10.3390\/md23020055","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T09:01:13Z","timestamp":1737622873000},"page":"55","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Components and Biological Activities of Venom from Lionfishes (Scorpaenidae: Pterois)"],"prefix":"10.3390","volume":"23","author":[{"given":"Candelario","family":"Rodriguez","sequence":"first","affiliation":[{"name":"Estaci\u00f3n Cient\u00edfica Coiba-AIP, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"},{"name":"Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Cient\u00edficas y Servicios de Alta Tecnolog\u00eda-AIP, (INDICASAT), Ciudad del Saber, Clayton, Panama 0843-01103, Panama"},{"name":"Sistema Nacional de Investigaci\u00f3n, Secretar\u00eda Nacional de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-8724","authenticated-orcid":false,"given":"Jafeth","family":"Carrasco","sequence":"additional","affiliation":[{"name":"Centro de Biolog\u00eda Celular y Molecular de Enfermedades, INDICASAT, Ciudad del Saber, Clayton, Panama 0843-01103, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-0338","authenticated-orcid":false,"given":"Gaspar","family":"Bruner-Montero","sequence":"additional","affiliation":[{"name":"Estaci\u00f3n Cient\u00edfica Coiba-AIP, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"},{"name":"Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Cient\u00edficas y Servicios de Alta Tecnolog\u00eda-AIP, (INDICASAT), Ciudad del Saber, Clayton, Panama 0843-01103, Panama"},{"name":"Sistema Nacional de Investigaci\u00f3n, Secretar\u00eda Nacional de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9875-9407","authenticated-orcid":false,"given":"Osmindo Rodrigues","family":"Pires J\u00fanior","sequence":"additional","affiliation":[{"name":"Estaci\u00f3n Cient\u00edfica Coiba-AIP, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"},{"name":"Laboratory of Toxinology, Department of Physiological Sciences, Institute of Biological Sciences, University of Brasilia, Brasilia 70910-900, DF, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-3772","authenticated-orcid":false,"given":"Marcelino","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Centro de Biodiversidad y Descubrimiento de Drogas, Instituto de Investigaciones Cient\u00edficas y Servicios de Alta Tecnolog\u00eda-AIP, (INDICASAT), Ciudad del Saber, Clayton, Panama 0843-01103, Panama"},{"name":"Sistema Nacional de Investigaci\u00f3n, Secretar\u00eda Nacional de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgardo","family":"D\u00edaz-Ferguson","sequence":"additional","affiliation":[{"name":"Estaci\u00f3n Cient\u00edfica Coiba-AIP, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"},{"name":"Sistema Nacional de Investigaci\u00f3n, Secretar\u00eda Nacional de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n, Ciudad del Saber, Clayton, Panama 0816-02852, Panama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aau7761","article-title":"Venoms to Rescue","volume":"361","author":"Holford","year":"2018","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/jhered\/esj034","article-title":"Venom Evolution Widespread in Fishes: A Phylogenetic Road Map for the Bioprospecting of Piscine Venoms","volume":"97","author":"Smith","year":"2006","journal-title":"J. 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