{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T04:09:06Z","timestamp":1789790946941,"version":"4.0.1"},"reference-count":315,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine organisms represent a source of unique chemical entities with valuable biomedical potentialities, broad diversity, and complexity. It is essential to ensure a reliable and sustainable supply of marine natural products (MNPs) for their translation into commercial drugs and other valuable products. From a structural point of view and with few exceptions, MNPs of pharmaceutical importance derive from the so-called secondary metabolism of marine organisms. When production strategies rely on marine macroorganisms, harvesting or culturing coupled with extraction procedures frequently remain the only alternative to producing these compounds on an industrial scale. Their supply can often be implemented with laboratory scale cultures for bacterial, fungal, or microalgal sources. However, a diverse approach, combining traditional methods with modern synthetic biology and biosynthesis strategies, must be considered for invertebrate MNPs, as they are usually naturally accumulated in only very small quantities. This review offers a comprehensive examination of various production strategies for MNPs, addressing the challenges related to supply, synthesis, and scalability. It also underscores recent biotechnological advancements that are likely to transform the current industrial-scale manufacturing methods for pharmaceuticals derived from marine sources.<\/jats:p>","DOI":"10.3390\/md23020069","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T10:07:56Z","timestamp":1738922876000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Advanced Technologies for Large Scale Supply of Marine Drugs"],"prefix":"10.3390","volume":"23","author":[{"given":"Henar","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, School of Engineering (EII), University of Valladolid (UVa), Dr. Mergelina, 47002 Valladolid, Spain"},{"name":"G.I.R. Computational Chemistry Group, Department of Physical Chemistry and Inorganic Chemistry, Science Faculty, University of Valladolid (UVa), Paseo de Bel\u00e9n 7, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2877-3235","authenticated-orcid":false,"given":"Mercedes","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, School of Engineering (EII), University of Valladolid (UVa), Dr. Mergelina, 47002 Valladolid, Spain"},{"name":"G.I.R. Bioforge, University of Valladolid (UVa), CIBER-BBN, Paseo de Bel\u00e9n 19, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8661-5413","authenticated-orcid":false,"given":"Luc\u00eda","family":"Pedraza","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, Science Faculty, University of Valladolid (UVa), Paseo de Bel\u00e9n 7, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Testera","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry, School of Engineering (EII), University of Valladolid (UVa), Dr. Mergelina, 47002 Valladolid, Spain"},{"name":"G.I.R. Bioforge, University of Valladolid (UVa), CIBER-BBN, Paseo de Bel\u00e9n 19, 47011 Valladolid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111756","DOI":"10.1016\/j.biopha.2021.111756","article-title":"Biosynthetic Versatility of Marine-Derived Fungi on the Delivery of Novel Antibacterial Agents against Priority Pathogens","volume":"140","author":"Gomes","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.phytol.2024.01.001","article-title":"Exploring the Potential of Marine Natural Products in Drug Development: A Comprehensive Review","volume":"59","author":"Banday","year":"2024","journal-title":"Phytochem. 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