{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:10:23Z","timestamp":1790881823017,"version":"4.1.0"},"reference-count":51,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060697"],"award-info":[{"award-number":["82060697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20212BBG71007"],"award-info":[{"award-number":["20212BBG71007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jiangxi Key Research and Development Program","award":["82060697"],"award-info":[{"award-number":["82060697"]}]},{"name":"Jiangxi Key Research and Development Program","award":["20212BBG71007"],"award-info":[{"award-number":["20212BBG71007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The rising prevalence of Alzheimer\u2019s disease (AD) underscores the urgent need for novel therapeutic agents derived from natural sources. Among flavonoids, 3\u2032,4\u2032,5,7-tetramethoxyflavone (TMF), a structural analog of luteolin, has gained attention for its favorable pharmacokinetics and potential neuroprotective properties. Despite the significant neuroprotective effects and favorable pharmacokinetics of TMF, its efficacy and mechanism of action in AD remain unclear. This study explored TMF\u2019s pharmacological effects in AD models, highlighting its ability to improve memory and cognitive deficits in APP\/PS1 mice. TMF reduced A\u03b2 plaques, NFTs formation, and glial activation while suppressing neuroinflammation through the MAPK\/NF-\u03baB pathway. Further analysis in LPS-induced BV2 cells revealed TMF\u2019s ability to reduce microglial activation. These findings highlight the anti-neuroinflammatory activity of TMF, suggesting its potential as a treatment for AD.<\/jats:p>","DOI":"10.3390\/md23020074","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T10:25:57Z","timestamp":1739355957000},"page":"74","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["TMF Attenuates Cognitive Impairment and Neuroinflammation by Inhibiting the MAPK\/NF-\u03baB Pathway in Alzheimer\u2019s Disease: A Multi-Omics Analysis"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-3966-7557","authenticated-orcid":false,"given":"Yonglin","family":"Liu","sequence":"first","affiliation":[{"name":"National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang 330096, China"},{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8644-2886","authenticated-orcid":false,"given":"Xinli","family":"Liang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang 330096, China"},{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4823-0590","authenticated-orcid":false,"given":"Yiguang","family":"Li","sequence":"additional","affiliation":[{"name":"National Key Laboratory for the Modernization of Classical and Famous Prescriptions of Chinese Medicine, Nanchang 330096, China"},{"name":"School of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, China"},{"name":"Research and Development Department, Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330103, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/0891988710383571","article-title":"Genetics of Alzheimer disease","volume":"23","author":"Bekris","year":"2010","journal-title":"J. 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