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Currently, the global prevalence of talaromycosis caused by TM is increasing, leading to an increased demand for anti-TM drugs. In our previous study, a novel 28-membered macrolide compound, antifungalmycin B (ANB), was isolated from Streptomyces hiroshimensis GXIMD 06359, exhibiting significant antifungal properties. However, its in vivo mechanisms and direct antifungal effects warrant further investigation. In this study, we employed a mouse model in conjunction with transcriptomic and proteomic approaches to explore the antifungal activity of ANB against T. marneffei. In an in vivo mouse model infected with T. marneffei infection, ANB significantly reduced fungal burdens in the liver, spleen, lungs, and kidneys. Additionally, it markedly decreased the levels of reactive oxygen species (ROS) and cytokines, including interleukin (IL)-1\u03b2, IL-6, and tumor necrosis factor (TNF)-\u03b1. Proteomic and transcriptomic studies, complemented by parallel reaction monitoring (PRM) analysis, revealed that ANB effectively disrupted acid biosynthesis and cellular energy metabolism, thereby impairing mitochondrial functions in T. marneffei. These effects were exerted through multiple pathways. These findings highlight the potential of ANB as a versatile inhibitor of polyene macrolide-resistant fungi, offering a promising therapeutic avenue for the treatment of talaromycosis.<\/jats:p>","DOI":"10.3390\/md23020076","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T11:08:51Z","timestamp":1739358531000},"page":"76","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Integration of Transcriptomics and Proteomics to Elucidate Inhibitory Effect and Mechanism of Antifungalmycin B from Marine Streptomyces hiroshimensis in Treating Talaromyces marneffei"],"prefix":"10.3390","volume":"23","author":[{"given":"Qiqi","family":"Li","sequence":"first","affiliation":[{"name":"Institute of Marine Drugs\/Faculty of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Guangxi Key Laboratory of Marine Drugs\/Guangxi University Engineering Research Center of 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disease in Mainland China","volume":"175","author":"Hu","year":"2013","journal-title":"Mycopathologia"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Qin, Y.Y., Huang, X.J., Chen, H., Liu, X.C., Li, Y., Hou, J.H., Li, A.X., Yan, X.F., and Chen, Y.K. (2020). Burden of Talaromyces marneffei infection in people living with HIV\/AIDS in Asia during ART era: A systematic review and meta-analysis. BMC Infect., 20.","DOI":"10.1186\/s12879-020-05260-8"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/cid\/cis1028","article-title":"Coccidioidomycosis acquired in Washington State","volume":"56","author":"Goldoft","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/cid\/ciab726","article-title":"Coronavirus disease 2019-associated mucormycosis: Risk factors and mechanisms of disease","volume":"74","author":"Narayanan","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cmi.2019.11.021","article-title":"A multicentre observational study on the epidemiology, risk factors, management and outcomes of mucormycosis in India","volume":"26","author":"Patel","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Zaongo, S.D., Zhang, F.Z., and Chen, Y.K. (2023). An overview of diagnostic and management strategies for Talaromycosis, an underrated disease. J. Fungi, 9.","DOI":"10.3390\/jof9060647"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s13225-018-0413-9","article-title":"The world\u2019s ten most feared fungi","volume":"93","author":"Hyde","year":"2018","journal-title":"Fungal Divers."},{"key":"ref_8","first-page":"1","article-title":"Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents: Recommendations from CDC, the national institutes of health, and the HIV medicine association of the infectious diseases society of America","volume":"58","author":"Kaplan","year":"2009","journal-title":"MMWR Recommen. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s40265-013-0069-4","article-title":"Amphotericin B formulations: A comparative review of efficacy and toxicity","volume":"73","author":"Hamill","year":"2013","journal-title":"Drugs"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"e0148016","DOI":"10.1128\/AAC.01480-16","article-title":"In vitro activity of posaconazole against Talaromyces marneffei by broth microdilution and etest methods and comparison to itraconazole, voriconazole, and anidulafungin","volume":"61","author":"Lau","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1742-6405-9-24","article-title":"Clinical characteristics and outcome of Penicillium marneffei infection among HIV-infected patients in northern Vietnam","volume":"9","author":"Larsson","year":"2012","journal-title":"AIDs Res. Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1111\/jam.14877","article-title":"Antifungal activity of marine-derived actinomycetes against Talaromyces marneffei","volume":"130","author":"Sangkanu","year":"2021","journal-title":"J. Appl. Microbiol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Jiang, C.P., Feng, G.F., Wang, Z., Liu, K., Qu, X.J., Liu, Y.H., Yi, X.X., and Gao, C.H. (2024). Antifungal activity of bamemacrolactine C against Talaromyces marneffei and its possible mechanisms of action. J. Appl. Microbiol., 135.","DOI":"10.1093\/jambio\/lxae297"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Wang, Z., Yin, J.L., Bai, M., Yang, J., Jiang, C.P., Yi, X.X., Liu, Y.H., and Gao, C.H. (2024). New polyene macrolide compounds from angrove-derived strain Streptomyces hiroshimensis GXIMD 06359: Isolation, antifungal activity, and mechanism against Talaromyces marneffei. Mar. Drugs, 22.","DOI":"10.3390\/md22010038"},{"key":"ref_15","first-page":"327","article-title":"Diversity and anti-aging activity of endophytic ctinobacteria from true mangrove plants collected from the west coast of Hainan","volume":"40","author":"Jiang","year":"2020","journal-title":"Guihaia"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e0228820","DOI":"10.1128\/mBio.02288-20","article-title":"Staphylococcal DNA repair is required for infection","volume":"11","author":"Ha","year":"2020","journal-title":"MBio"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/13510002.2022.2046423","article-title":"Role of mitochondrial reactive oxygen species in homeostasis regulation","volume":"27","author":"Zhang","year":"2022","journal-title":"Redox Rep."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Wijayawardene, N.N., Boonyuen, N., Ranaweera, C.B., de Zoysa, H.K.S., Padmathilake, R.E., Nifla, F., Dai, D.Q., Liu, Y.X., Suwannarach, N., and Kumla, J. (2023). OMICS and other advanced technologies in mycological applications. J. Fungi, 9.","DOI":"10.3390\/jof9060688"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"myac053","DOI":"10.1093\/mmy\/myac053","article-title":"iTRAQ-based proteomics revealed baicalein enhanced oxidative stress of Candida albicans by upregulating CPD2 expression","volume":"60","author":"Lv","year":"2022","journal-title":"Med. Mycol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11010-019-03667-9","article-title":"ROS and diseases: Role in metabolism and energy supply","volume":"467","author":"Yang","year":"2020","journal-title":"Mol. Cell. Biochem."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri3423","article-title":"Beyond oxidative stress: An immunologist\u2019s guide to reactive oxygen species","volume":"13","author":"Nathan","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1046\/j.1365-2249.1997.d01-945.x","article-title":"CD4+ T cell-mediated fatal hyperinflammatory reactions in mice infected with Penicillium marneffei","volume":"107","author":"Kudeken","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/ofid\/ofz205","article-title":"Innate immunity acts as the major regulator in Talaromyces marneffei coinfected AIDS patients: Cytokine profile surveillance during initial 6-month antifungal therapy","volume":"6","author":"Dong","year":"2019","journal-title":"Open Forum Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s00726-022-03207-8","article-title":"An active domain SA-2 derived from cystatin-SA, and its antifungal activity","volume":"55","author":"Liu","year":"2023","journal-title":"Amino Acids"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"174955","DOI":"10.1016\/j.ejphar.2022.174955","article-title":"Eugenol protects against Aspergillus fumigatus keratitis by inhibiting inflammatory response and reducing fungal load","volume":"924","author":"Yu","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00253-016-7898-5","article-title":"Overexpression of PMA1 enhances tolerance to various types of stress and constitutively activates the SAPK pathways in Saccharomyces Cerevisiae","volume":"101","author":"Lee","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Rene, N.S., Hayek, S.R., Frye, J.E., Abeyta, E.L., Bernardo, S.M., Parra, K.J., and Lee, S.A. (2019). Candida albicans pma1p contributes to growth, pH homeostasis, and hyphal formation. Front. Microbiol., 10.","DOI":"10.3389\/fmicb.2019.01012"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"21963","DOI":"10.1074\/jbc.M601057200","article-title":"Molecular characterization of Trypanosoma brucei p-type H+-ATPases","volume":"281","author":"Luo","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/319689a0","article-title":"Yeast plasma membrane ATPase is essential for growth and has homology with (Na+ + K+), K+- and Ca2+-ATPases","volume":"319","author":"Serrano","year":"1986","journal-title":"Nature"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.1007\/s00253-022-12036-4","article-title":"The plasma membrane H+-ATPase is critical for cell growth and pathogenicity in Penicillium digitatum","volume":"106","author":"Li","year":"2022","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Zhang, C.Q., Ding, D.D., Wang, B., Wang, Y.P., Li, N., Li, R.Y., Yan, Y.K., and He, J. (2023). Effect of potato glycoside alkaloids on energy metabolism of Fusarium solani. J. Fungi, 9.","DOI":"10.3390\/jof9070777"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.sbi.2008.09.008","article-title":"The multienzyme architecture of eukaryotic fatty acid synthases","volume":"18","author":"Leibundgut","year":"2008","journal-title":"Curr. Opin. Struc. Biol."},{"key":"ref_33","first-page":"31","article-title":"Fatty acid synthase: Structure, function, and regulation","volume":"99","author":"Graf","year":"2022","journal-title":"Subcellul. Biochem."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1017\/S0033583510000156","article-title":"Structure and function of eukaryotic fatty acid synthases","volume":"43","author":"Maier","year":"2010","journal-title":"Q. Rev. Biophys."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/oxfordjournals.jbchem.a129827","article-title":"The action mechanism of cerulenin. I. effect of cerulenin on sterol and fatty acid biosynthesis in yeast","volume":"71","author":"Nomura","year":"1972","journal-title":"J. Biochem."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Bitencourt, T.A., Komoto, T.T., Massaroto, B.G., Saraiva Miranda, C.E., Beleboni, R.O., Marins, M., and Fachin, A.L. (2013). Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement. Altern. Med., 13.","DOI":"10.1186\/1472-6882-13-229"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.chembiol.2023.06.005","article-title":"Identification of triazenyl indoles as inhibitors of fungal fatty acid biosynthesis with broad-spectrum activity","volume":"30","author":"Iyer","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wulfert, S., Schilasky, S., and Krueger, S. (2020). Transcriptional and biochemical characterization of cytosolic pyruvate kinases in Arabidopsis thaliana. Plants, 9.","DOI":"10.3390\/plants9030353"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.vetmic.2004.11.003","article-title":"Antibacterial effects of the Cu(II)-exchanged montmorillonite on Escherichia coli K88 and Salmonella choleraesuis","volume":"105","author":"Tong","year":"2005","journal-title":"Vet. Microbiol."},{"key":"ref_40","unstructured":"Voet, D., Voet, J.G., and Pratt, C.W. (2016). Fundamentals of biochemistry: Life at the molecular level, fifth edition, John Wiley & Sons Inc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s00294-019-01025-2","article-title":"VdOGDH is involved in energy metabolism and required for virulence of Verticillium dahliae","volume":"66","author":"Li","year":"2020","journal-title":"Curr. Genet."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/2\/76\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:30:25Z","timestamp":1760027425000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/2\/76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,10]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["md23020076"],"URL":"https:\/\/doi.org\/10.3390\/md23020076","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,10]]}}}