{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:46:56Z","timestamp":1790185616638,"version":"4.1.0"},"reference-count":41,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety","award":["GDPKLAPPS20l7"],"award-info":[{"award-number":["GDPKLAPPS20l7"]}]},{"name":"Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety","award":["4RS23002h"],"award-info":[{"award-number":["4RS23002h"]}]},{"name":"Guangdong Medical University","award":["GDPKLAPPS20l7"],"award-info":[{"award-number":["GDPKLAPPS20l7"]}]},{"name":"Guangdong Medical University","award":["4RS23002h"],"award-info":[{"award-number":["4RS23002h"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The present study investigated the protective effects and possible mechanisms of an ultrafiltration fraction of Sipunculus nudus hydrolysate (UFSH) on cisplatin-induced kidney damage in a mouse model. The results showed that UFSH significantly attenuated cisplatin-induced nephrotoxicity by inhibiting increases in blood urea nitrogen (BUN) and serum creatinine (SCr). Additionally, UFSH treatment significantly alleviated cisplatin-induced renal histopathological changes, such as significant dilation of renal tubules, cast formation, and tubular cell necrosis, as well as tubulointerstitial fibrosis. Moreover, UFSH decreased cisplatin-induced oxidative stress by increasing the activities of antioxidant enzymes SOD and GSH-Px, while reducing the malondialdehyde (MDA) level in the kidney. Furthermore, UFSH significantly inhibited cisplatin-induced increases in inflammatory cytokines, including Interleukin 1-beta (IL-1\u03b2), Interleukin-6 (IL-6), and Tumor necrosis factor-alpha (TNF-\u03b1). Western blotting revealed that UFSH inhibited the phosphorylation of the inflammation-associated MAPK\/NF-\u03baB signaling pathway, lowered the expression of the apoptosis-related protein Bax, and reversed the reduction in the anti-apoptotic Bcl-2 protein. This investigation demonstrated that UFSH can ameliorate cisplatin-induced nephrotoxicity by mitigating oxidative stress, inflammation, and apoptosis.<\/jats:p>","DOI":"10.3390\/md23030100","type":"journal-article","created":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T10:04:28Z","timestamp":1740391468000},"page":"100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ameliorative Effect of Sipunculus nudus Hydrolysate on Cisplatin-Induced Nephrotoxicity by Mitigating Oxidative Stress, Inflammation and Apoptosis"],"prefix":"10.3390","volume":"23","author":[{"given":"Susu","family":"Tao","sequence":"first","affiliation":[{"name":"School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang 524023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang 524023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialong","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Food Science & Technology, Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Zhanjiang 524088, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafang","family":"Yuan","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Shen","sequence":"additional","affiliation":[{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wei","sequence":"additional","affiliation":[{"name":"School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang 524023, China"},{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhilan","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang 524023, China"},{"name":"College of Food Science & Technology, Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Zhanjiang 524088, China"},{"name":"The Marine Biomedical Research Institute of Guangdong Zhanjiang, Zhanjiang 524023, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,2,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S0270-9295(03)00089-5","article-title":"Cisplatin nephrotoxicity","volume":"23","author":"Arany","year":"2003","journal-title":"Semin. 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