{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:55:23Z","timestamp":1791928523040,"version":"4.3.4"},"reference-count":38,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:00:00Z","timestamp":1742342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Natural Science Foundation of China","award":["82202006"],"award-info":[{"award-number":["82202006"]}]},{"name":"the National Natural Science Foundation of China","award":["32472334"],"award-info":[{"award-number":["32472334"]}]},{"name":"the National Natural Science Foundation of China","award":["2022AH050778"],"award-info":[{"award-number":["2022AH050778"]}]},{"name":"the National Natural Science Foundation of China","award":["22GYY007HJ07"],"award-info":[{"award-number":["22GYY007HJ07"]}]},{"name":"the National Natural Science Foundation of China","award":["2023CXY0307"],"award-info":[{"award-number":["2023CXY0307"]}]},{"name":"Key Project of Natural Science Research of Anhui Education Department","award":["82202006"],"award-info":[{"award-number":["82202006"]}]},{"name":"Key Project of Natural Science Research of Anhui Education Department","award":["32472334"],"award-info":[{"award-number":["32472334"]}]},{"name":"Key Project of Natural Science Research of Anhui Education Department","award":["2022AH050778"],"award-info":[{"award-number":["2022AH050778"]}]},{"name":"Key Project of Natural Science Research of Anhui Education Department","award":["22GYY007HJ07"],"award-info":[{"award-number":["22GYY007HJ07"]}]},{"name":"Key Project of Natural Science Research of Anhui Education Department","award":["2023CXY0307"],"award-info":[{"award-number":["2023CXY0307"]}]},{"name":"the Xiamen Marine Development Program of China","award":["82202006"],"award-info":[{"award-number":["82202006"]}]},{"name":"the Xiamen Marine Development Program of China","award":["32472334"],"award-info":[{"award-number":["32472334"]}]},{"name":"the Xiamen Marine Development Program of China","award":["2022AH050778"],"award-info":[{"award-number":["2022AH050778"]}]},{"name":"the Xiamen Marine Development Program of China","award":["22GYY007HJ07"],"award-info":[{"award-number":["22GYY007HJ07"]}]},{"name":"the Xiamen Marine Development Program of China","award":["2023CXY0307"],"award-info":[{"award-number":["2023CXY0307"]}]},{"name":"the Science and Technology Program of Xiamen City","award":["82202006"],"award-info":[{"award-number":["82202006"]}]},{"name":"the Science and Technology Program of Xiamen City","award":["32472334"],"award-info":[{"award-number":["32472334"]}]},{"name":"the Science and Technology Program of Xiamen City","award":["2022AH050778"],"award-info":[{"award-number":["2022AH050778"]}]},{"name":"the Science and Technology Program of Xiamen City","award":["22GYY007HJ07"],"award-info":[{"award-number":["22GYY007HJ07"]}]},{"name":"the Science and Technology Program of Xiamen City","award":["2023CXY0307"],"award-info":[{"award-number":["2023CXY0307"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>T cells play pivotal roles in inflammation\u2019s initiation and progression. Exploring natural compounds that regulate T cell function is crucial for preventing and treating inflammation. Herein, we report that Alternariol (AOH), a marine-derived secondary metabolite, exerts an anti-inflammatory activity by targeting T cell function. Using an ovalbumin (OVA)-induced OT-II CD4+ T cell activation model, we demonstrated that AOH potently suppresses T cell proliferation and cytokine secretion, mildly promotes T cell apoptosis, and spares antigen presentation processes. Mechanistically, AOH controlled early T cell activation by inhibiting the expression of activation markers (CD69, CD25, CD44) and transcription factors (T-bet, Eomes), leading to impaired Th1 cytokine production. In vivo experiments revealed that AOH attenuated OVA-induced lung injury in mice by reducing immune cell infiltration in pulmonary tissues and draining lymph nodes. Notably, AOH dramatically suppressed OVA-specific T cells migrating to the inflammatory lung while impairing T-cell-mediated other immune cell infiltration. Collectively, AOH exhibited potent anti-inflammatory effects by modulating T cell proliferation, function, and migration, offering a promising therapeutic strategy for T-cell-mediated inflammatory diseases.<\/jats:p>","DOI":"10.3390\/md23030133","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T07:48:37Z","timestamp":1742370517000},"page":"133","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Marine-Derived Alternariol Suppresses Inflammation by Regulating T Cell Activation and Migration"],"prefix":"10.3390","volume":"23","author":[{"given":"Chenfeng","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Cell Biology, School of Life Science, Anhui Medical University, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fudie","family":"Gu","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengbiao","family":"Zou","sequence":"additional","affiliation":[{"name":"Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2233-0732","authenticated-orcid":false,"given":"Fengli","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Life Science, Anhui Medical University, Hefei 230031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dashuai","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, School of Life Science, Anhui Medical University, Hefei 230031, 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4967-0844","authenticated-orcid":false,"given":"Xianwen","family":"Yang","sequence":"additional","affiliation":[{"name":"Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2500-3892","authenticated-orcid":false,"given":"Wen-Hsien","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8689-0504","authenticated-orcid":false,"given":"Guangming","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China"},{"name":"Faculty of Marine Biology, Xiamen Ocean Vocational College, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen 361102, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9602-6680","authenticated-orcid":false,"given":"Qingmei","family":"Liu","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, 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