{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T01:48:08Z","timestamp":1790041688641,"version":"4.0.1"},"reference-count":26,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:00:00Z","timestamp":1743120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82173809"],"award-info":[{"award-number":["82173809"]}]},{"name":"National Natural Science Foundation of China","award":["82470437"],"award-info":[{"award-number":["82470437"]}]},{"name":"National Natural Science Foundation of China","award":["2023B1111050012"],"award-info":[{"award-number":["2023B1111050012"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province, China","award":["82173809"],"award-info":[{"award-number":["82173809"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province, China","award":["82470437"],"award-info":[{"award-number":["82470437"]}]},{"name":"Key-Area Research and Development Program of Guangdong Province, China","award":["2023B1111050012"],"award-info":[{"award-number":["2023B1111050012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Isaridin E, a cyclodepsipeptide derived from the marine fungus Beauveria felina (SYSU-MS7908), has been demonstrated to possess multiple biological properties. In this study, we employed both lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs) and a LPS-induced murine endotoxemia model to investigate its anti-inflammatory effects. Our results revealed that isaridin E suppressed the expression of pro-inflammatory cytokines and adhesion molecules in a concentration dependent manner, while also reducing monocyte adhesion to endothelial cells. Furthermore, this compound attenuated vascular hyperpermeability and inflammatory cell infiltration in the lungs, as well as preserving the integrity of the aortic and pulmonary tissues. At the molecular level, isaridin E was found to downregulate TLR4 expression, increase I\u03baB\u03b1 levels, and inhibit the LPS-induced phosphorylation and nuclear translocation of NF-\u03baB p65. In conclusion, our findings indicate that isaridin E exerts robust anti-inflammatory effects in LPS-induced endotoxemia through the suppression of the TLR4\/NF-\u03baB signaling axis, positioning it as a promising therapeutic candidate for vascular inflammatory disorders.<\/jats:p>","DOI":"10.3390\/md23040145","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:45:51Z","timestamp":1743144351000},"page":"145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The Marine Compound Isaridin E Ameliorates Lipopolysaccharide-Induced Vascular Endothelial Inflammation via the Downregulation of the TLR4\/NF-\u03baB Signaling Pathway"],"prefix":"10.3390","volume":"23","author":[{"given":"Jing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"},{"name":"Department of Pharmacy, The Second Clinical Medical College, Southern Medical University, Guangzhou 510280, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Quan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Sheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-4015","authenticated-orcid":false,"given":"Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Marine Sciences, Sun Yat-sen University, Guangzhou 510275, China"},{"name":"Southern Marine Sciences and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-0206","authenticated-orcid":false,"given":"Sen-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Marine Sciences, Sun Yat-sen University, Guangzhou 510275, China"},{"name":"Southern Marine Sciences and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7429-0456","authenticated-orcid":false,"given":"Yan-Hua","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,3,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Barbu, E., Popescu, M.R., Popescu, A.C., and Balanescu, S.M. 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