{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:14:25Z","timestamp":1789409665171,"version":"build-2803163510"},"reference-count":159,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:00:00Z","timestamp":1743724800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172551"],"award-info":[{"award-number":["82172551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Chronic obstructive pulmonary disease (COPD) is frequently accompanied by skeletal muscle dysfunction, a critical and severe extrapulmonary complication. This dysfunction contributes to reduced exercise capacity, increased frequency of acute exacerbations, and elevated mortality, serving as an independent risk factor for poor prognosis in COPD patients. Owing to the unique physicochemical conditions of the marine environment, marine-derived bioactive compounds exhibit potent anti-inflammatory and antioxidant properties, demonstrating therapeutic potential for ameliorating COPD skeletal muscle dysfunction. This review summarizes marine-derived bioactive compounds with promising efficacy against skeletal muscle dysfunction in COPD, including polysaccharides, lipids, polyphenols, peptides, and carotenoids. The discussed compounds have shown bioactivities in promoting skeletal muscle health and suppressing muscle atrophy, thereby providing potential strategies for the prevention and treatment of COPD skeletal muscle dysfunction. These findings may expand the therapeutic strategies for managing COPD skeletal muscle dysfunction.<\/jats:p>","DOI":"10.3390\/md23040158","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T06:52:56Z","timestamp":1743749576000},"page":"158","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Marine-Derived Bioactive Compounds: A Promising Strategy for Ameliorating Skeletal Muscle Dysfunction in COPD"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-3510","authenticated-orcid":false,"given":"Meiling","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1061-1123","authenticated-orcid":false,"given":"Linhong","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglan","family":"He","sequence":"additional","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8201-147X","authenticated-orcid":false,"given":"Yingqi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8379-0292","authenticated-orcid":false,"given":"Xiaodan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Sports Rehabilitation, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1164\/rccm.202204-0671PP","article-title":"Definition and Nomenclature of Chronic Obstructive Pulmonary Disease: Time for Its Revision","volume":"206","author":"Celli","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e1183","DOI":"10.1016\/S2214-109X(23)00217-6","article-title":"The global economic burden of chronic obstructive pulmonary disease for 204 countries and territories in 2020\u201350: A health-augmented macroeconomic modelling study","volume":"11","author":"Chen","year":"2023","journal-title":"Lancet Glob. Health"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1016\/S0140-6736(18)30841-9","article-title":"Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): A national cross-sectional study","volume":"391","author":"Wang","year":"2018","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1611179335","DOI":"10.1177\/17534666231208633","article-title":"Role of Nrf2 and exercise in alleviating COPD-induced skeletal muscle dysfunction","volume":"17","author":"Jiang","year":"2023","journal-title":"Ther. Adv. Respir. Dis."},{"key":"ref_5","first-page":"214","article-title":"Structural and functional changes in the skeletal muscles of COPD patients: The \u201ccompartments\u201d theory","volume":"56","author":"Gea","year":"2001","journal-title":"Monaldi Arch. Chest Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"139087","DOI":"10.1016\/j.foodchem.2024.139087","article-title":"Investigating the nutritional viability of marine-derived protein for sustainable future development","volume":"448","author":"Raja","year":"2024","journal-title":"Food Chem."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1080\/10408398.2021.1893643","article-title":"Functional foods and bioactive ingredients harnessed from the ocean: Current status and future perspectives","volume":"62","author":"Lobine","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.4062\/biomolther.2016.181","article-title":"Marine-Derived Pharmaceuticals\u2014Challenges and Opportunities","volume":"24","author":"Lindequist","year":"2016","journal-title":"Biomol. Ther."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.3390\/ijms24076454","article-title":"Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting","volume":"24","author":"Henrot","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4","DOI":"10.31665\/JFB.2022.18316","article-title":"Novel marine bioactives: Application in functional foods, nutraceuticals, and pharmaceuticals","volume":"19","author":"Shahidi","year":"2022","journal-title":"J. Food Bioact."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1183\/16000617.00000315","article-title":"An official American Thoracic Society\/European Respiratory Society statement: Research questions in COPD","volume":"24","author":"Celli","year":"2015","journal-title":"Eur. Respir. Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1164\/rccm.201710-2140CI","article-title":"Skeletal Muscle Dysfunction in Chronic Obstructive Pulmonary Disease. What We Know and Can Do for Our Patients","volume":"198","author":"Jaitovich","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1183\/09031936.00128008","article-title":"Systemic manifestations and comorbidities of COPD","volume":"33","author":"Barnes","year":"2009","journal-title":"Eur. Respir. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1002\/jcsm.13213","article-title":"Glycyl-l-histidyl-l-lysine-Cu2+ rescues cigarette smoking-induced skeletal muscle dysfunction via a sirtuin 1-dependent pathway","volume":"14","author":"Deng","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"190049","DOI":"10.1183\/16000617.0049-2019","article-title":"Sarcopenia in COPD: A systematic review and meta-analysis","volume":"28","author":"Benz","year":"2019","journal-title":"Eur. Respir. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1513\/AnnalsATS.201307-229OC","article-title":"Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. A cross-sectional study","volume":"11","author":"McDonald","year":"2014","journal-title":"Ann. Am. Thorac. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"101587","DOI":"10.1016\/j.rehab.2021.101587","article-title":"Quadriceps weakness associated with mortality in individuals with chronic obstructive pulmonary disease","volume":"65","author":"Spositon","year":"2022","journal-title":"Ann. Phys. Rehabil. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"E80E89","DOI":"10.1152\/ajpendo.00544.2020","article-title":"Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure","volume":"321","author":"Decker","year":"2021","journal-title":"Am. J. Physiol.-Endocrinol. Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1152\/japplphysiol.00508.2012","article-title":"Loss of quadriceps muscle oxidative phenotype and decreased endurance in patients with mild-to-moderate COPD","volume":"114","author":"Slot","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1183\/09031936.01.17509390","article-title":"Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease","volume":"17","author":"Gea","year":"2001","journal-title":"Eur. Respir. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00008483-200011000-00004","article-title":"Distribution of muscle weakness in patients with stable chronic obstructive pulmonary disease","volume":"20","author":"Gosselink","year":"2000","journal-title":"J. Cardiopulm. Rehabil."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.pharmthera.2016.06.013","article-title":"Emerging therapies for the treatment of skeletal muscle wasting in chronic obstructive pulmonary disease","volume":"166","author":"Passey","year":"2016","journal-title":"Pharmacol. Ther."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/COPD.S280540","article-title":"Towards Personalized Management of Sarcopenia in COPD","volume":"16","author":"Gosker","year":"2021","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/thx.2003.019588","article-title":"Association between chronic obstructive pulmonary disease and systemic inflammation: A systematic review and a meta-analysis","volume":"59","author":"Gan","year":"2004","journal-title":"Thorax"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/thx.2005.044941","article-title":"Skeletal muscle weakness, reduced exercise tolerance, and COPD: Is systemic inflammation the missing link?","volume":"61","author":"Sin","year":"2006","journal-title":"Thorax"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/978-981-13-1435-3_12","article-title":"NF-kB and Inflammatory Cytokine Signalling: Role in Skeletal Muscle Atrophy","volume":"1088","author":"Thoma","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Jimenez-Gutierrez, G.E., Mart\u00ednez-G\u00f3mez, L.E., Mart\u00ednez-Armenta, C., Pineda, C., Mart\u00ednez-Nava, G.A., and Lopez-Reyes, A. (2022). Molecular Mechanisms of Inflammation in Sarcopenia: Diagnosis and Therapeutic Update. Cells, 11.","DOI":"10.3390\/cells11152359"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: A concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.jshs.2024.05.001","article-title":"Reactive oxygen species promote endurance exercise-induced adaptations in skeletal muscles","volume":"13","author":"Powers","year":"2024","journal-title":"J. Sport. Health Sci."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Duranti, G. (2023). Oxidative Stress and Skeletal Muscle Function. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241210227"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"115664","DOI":"10.1016\/j.bcp.2023.115664","article-title":"Oxidative stress: Roles in skeletal muscle atrophy","volume":"214","author":"Zhang","year":"2023","journal-title":"Biochem. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.tem.2019.07.009","article-title":"The FoxO-Autophagy Axis in Health and Disease","volume":"30","author":"Cheng","year":"2019","journal-title":"Trends Endocrinol. Metab."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1152\/japplphysiol.00893.2012","article-title":"Role of autophagy in COPD skeletal muscle dysfunction","volume":"114","author":"Hussain","year":"2013","journal-title":"J. Appl. Physiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.freeradbiomed.2014.11.006","article-title":"Oxidative stress, redox signaling pathways, and autophagy in cachectic muscles of male patients with advanced COPD and lung cancer","volume":"79","author":"Rodriguez","year":"2015","journal-title":"Free. Radic. Biol. Med."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1164\/rccm.201304-0732OC","article-title":"Autophagy in locomotor muscles of patients with chronic obstructive pulmonary disease","volume":"188","author":"Guo","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1165\/rcmb.2021-0351OC","article-title":"Deaccelerated Myogenesis and Autophagy in Genetically Induced Pulmonary Emphysema","volume":"66","author":"Balnis","year":"2022","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1186\/s12967-023-04369-z","article-title":"Mitochondrial dysfunction: Roles in skeletal muscle atrophy","volume":"21","author":"Chen","year":"2023","journal-title":"J. Transl. Med."},{"key":"ref_38","first-page":"32","article-title":"Mitochondrial quality control in human health and disease","volume":"11","author":"Liu","year":"2024","journal-title":"Mil. Med. Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1111\/jcmm.15194","article-title":"Mitochondrial biogenesis: An update","volume":"24","author":"Popov","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1183\/09031936.00051012","article-title":"Impaired muscle mitochondrial density and\/or function: A COPD-specific mitochondropathy or simply deconditioning?","volume":"40","author":"Lazaar","year":"2012","journal-title":"Eur. Respir. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1183\/09031936.00144106","article-title":"Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD","volume":"30","author":"Remels","year":"2007","journal-title":"Eur. Respir. J."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"15007","DOI":"10.1038\/s41598-018-33471-2","article-title":"Molecular signalling towards mitochondrial breakdown is enhanced in skeletal muscle of patients with chronic obstructive pulmonary disease (COPD)","volume":"8","author":"Leermakers","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s41419-023-06154-8","article-title":"Autophagy: Regulator of cell death","volume":"14","author":"Liu","year":"2023","journal-title":"Cell Death Dis."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"736","DOI":"10.7150\/thno.79876","article-title":"Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1002\/jcsm.12988","article-title":"Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia","volume":"13","author":"Ito","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41392-023-01547-9","article-title":"Mitochondrial dynamics in health and disease: Mechanisms and potential targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"111212","DOI":"10.1016\/j.mad.2020.111212","article-title":"Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease","volume":"186","author":"Liu","year":"2020","journal-title":"Mech. Ageing Dev."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1126\/science.1219855","article-title":"Mitochondrial fission, fusion, and stress","volume":"337","author":"Youle","year":"2012","journal-title":"Science"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.21037\/atm-21-5891","article-title":"Effect of cigarette smoke extract on mitochondrial division in mouse quadriceps femoris cells","volume":"9","author":"Tan","year":"2021","journal-title":"Ann. Transl. Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3390\/nu7010239","article-title":"Fucoidan supplementation improves exercise performance and exhibits anti-fatigue action in mice","volume":"7","author":"Chen","year":"2014","journal-title":"Nutrients"},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Yang, C., Dwan, C., Wimmer, B.C., Wilson, R., Johnson, L., and Caruso, V. (2024). Fucoidan from Undaria pinnatifida Enhances Exercise Performance and Increases the Abundance of Beneficial Gut Bacteria in Mice. Mar. Drugs, 22.","DOI":"10.20944\/preprints202409.1494.v1"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"e14730","DOI":"10.14814\/phy2.14730","article-title":"Oral fucoidan improves muscle size and strength in mice","volume":"9","author":"McBean","year":"2021","journal-title":"Physiol. Rep."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2224751","DOI":"10.1080\/15502783.2023.2224751","article-title":"Effects of fucoidan supplementation on inflammatory and immune response after high-intensity exercise","volume":"20","author":"McFadden","year":"2023","journal-title":"J. Int. Soc. Sport. Nutr."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10126-016-9709-5","article-title":"Stimulatory Effect of Balanced Deep-Sea Water Containing Chitosan Oligosaccharides on Glucose Uptake in C2C12 Myotubes","volume":"18","author":"Ha","year":"2016","journal-title":"Mar. Biotechnol."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Jeong, H.W., Cho, S.Y., Kim, S., Shin, E.S., Kim, J.M., Song, M.J., Park, P.J., Sohn, J.H., Park, H., and Seo, D.B. (2012). Chitooligosaccharide induces mitochondrial biogenesis and increases exercise endurance through the activation of Sirt1 and AMPK in rats. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040073"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1248\/bpb.33.1128","article-title":"Effects of chitooligosaccharide lactate salt on sleep deprivation-induced fatigue in mice","volume":"33","author":"Cho","year":"2010","journal-title":"Biol. Pharm. Bull."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1080\/15376516.2016.1222643","article-title":"Hepatic and skeletal muscle mitochondrial toxicity of chitosan oligosaccharides of normal and diabetic rats","volume":"26","author":"Teodoro","year":"2016","journal-title":"Toxicol. Mech. Method"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"126936","DOI":"10.1016\/j.ijbiomac.2023.126936","article-title":"Anti-inflammatory potential of ulvan","volume":"253","author":"Latire","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ijbiomac.2018.02.104","article-title":"Antioxidant activity of purified ulvan in hyperlipidemic mice","volume":"113","author":"Li","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.21037\/apm-22-254","article-title":"Effects of omega-3 supplementation on quality of life, nutritional status, inflammatory parameters, lipid profile, exercise tolerance and inhaled medications in chronic obstructive pulmonary disease","volume":"11","author":"Fekete","year":"2022","journal-title":"Ann. Palliat. Med."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jnutbio.2011.04.005","article-title":"Association between \u03a93 and \u03a96 fatty acid intakes and serum inflammatory markers in COPD","volume":"23","author":"Sauleda","year":"2012","journal-title":"J. Nutr. Biochem."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1016\/j.clnu.2024.08.004","article-title":"Functional and metabolic effects of omega-3 polyunsaturated fatty acid supplementation and the role of \u03b2-hydroxy-\u03b2-methylbutyrate addition in chronic obstructive pulmonary disease: A randomized clinical trial","volume":"43","author":"Engelen","year":"2024","journal-title":"Clin. Nutr."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/BF02976680","article-title":"Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa","volume":"26","author":"Lee","year":"2003","journal-title":"Arch. Pharm. Res."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Ryu, B., Oh, S., Yang, H.W., Sosorburam, B., Chung, D.M., Seo, M., Park, S.J., Byun, K., and Jeon, Y.J. (2022). Diphlorethohydroxycarmalol Derived from Ishige okamurae Improves Behavioral and Physiological Responses of Muscle Atrophy Induced by Dexamethasone in an In-Vivo Model. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14040719"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Kim, S.Y., Lee, J.H., Kang, N., Kim, K.N., and Jeon, Y.J. (2021). The Effects of Marine Algal Polyphenols, Phlorotannins, on Skeletal Muscle Growth in C2C12 Muscle Cells via Smad and IGF-1 Signaling Pathways. Mar. Drugs, 19.","DOI":"10.3390\/md19050266"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"8659","DOI":"10.1039\/D0FO01713B","article-title":"Anti-fatigue property of the oyster polypeptide fraction and its effect on gut microbiota in mice","volume":"11","author":"Xiao","year":"2020","journal-title":"Food Funct."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.3892\/mmr.2017.6443","article-title":"Pyropia yezoensis peptide PYP1-5 protects against dexamethasone-induced muscle atrophy through the downregulation of atrogin1\/MAFbx and MuRF1 in mouse C2C12 myotubes","volume":"15","author":"Lee","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Guo, Z., Lin, D., Guo, J., Zhang, Y., and Zheng, B. (2017). In Vitro Antioxidant Activity and In Vivo Anti-Fatigue Effect of Sea Horse (Hippocampus) Peptides. Molecules, 22.","DOI":"10.3390\/molecules22030482"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s00774-022-01371-1","article-title":"Oxidative stress causes muscle structural alterations via p38 MAPK signaling in COPD mouse model","volume":"40","author":"Mano","year":"2022","journal-title":"J. Bone Miner. Metab."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/01635581.2024.2335584","article-title":"Astaxanthin Ameliorates Skeletal Muscle Atrophy in Mice with Cancer Cachexia","volume":"76","author":"Yu","year":"2024","journal-title":"Nutr. Cancer"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"151138","DOI":"10.1016\/j.bbrc.2024.151138","article-title":"Astaxanthin ameliorates dexamethasone-induced skeletal muscle atrophy and disorders of glucolipid metabolism","volume":"743","author":"Yue","year":"2025","journal-title":"Biochem. Bioph Res. Commun."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"e12885","DOI":"10.14814\/phy2.12885","article-title":"Astaxanthin intake attenuates muscle atrophy caused by immobilization in rats","volume":"4","author":"Shibaguchi","year":"2016","journal-title":"Physiol. Rep."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"111590","DOI":"10.1016\/j.biopha.2021.111590","article-title":"Fucoxanthin rescues dexamethasone induced C2C12 myotubes atrophy","volume":"139","author":"Zhiyin","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Yoshikawa, M., Hosokawa, M., Miyashita, K., Nishino, H., and Hashimoto, T. (2021). Effects of Fucoxanthin on the Inhibition of Dexamethasone-Induced Skeletal Muscle Loss in Mice. Nutrients, 13.","DOI":"10.3390\/nu13041079"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1007\/s11033-020-05369-8","article-title":"Fucoxanthinol attenuates oxidative stress-induced atrophy and loss in myotubes and reduces the triacylglycerol content in mature adipocytes","volume":"47","author":"Yoshikawa","year":"2020","journal-title":"Mol. Biol. Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"109248","DOI":"10.1016\/j.jnutbio.2022.109248","article-title":"\u03b2-Carotene suppresses cancer cachexia by regulating the adipose tissue metabolism and gut microbiota dysregulation","volume":"114","author":"Kim","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1017\/S0007114512003297","article-title":"The preventive effect of \u03b2-carotene on denervation-induced soleus muscle atrophy in mice","volume":"109","author":"Ogawa","year":"2013","journal-title":"Br. J. Nutr."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3177\/jnsv.61.481","article-title":"\u03b2-Carotene Increases Muscle Mass and Hypertrophy in the Soleus Muscle in Mice","volume":"61","author":"Kitakaze","year":"2015","journal-title":"J. Nutr. Sci. Vitaminol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Noguchi, M., Kitakaze, T., Kobayashi, Y., Mukai, K., Harada, N., and Yamaji, R. (2020). \u03b2-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice. Nutrients, 12.","DOI":"10.3390\/nu12082180"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/ajcn\/nqaa288","article-title":"Total carotenoid intake is associated with reduced loss of grip strength and gait speed over time in adults: The Framingham Offspring Study","volume":"113","author":"Sahni","year":"2021","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3390\/md19040188","article-title":"Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids","volume":"19","author":"Pereira","year":"2021","journal-title":"Mar. Drugs"},{"key":"ref_83","first-page":"43","article-title":"Natural Polysaccharide: Modification and Application","volume":"6","author":"Chen","year":"2021","journal-title":"Pap. Biomater."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.carbpol.2016.08.005","article-title":"A review about the development of fucoidan in antitumor activity: Progress and challenges","volume":"154","author":"Wu","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_85","doi-asserted-by":"crossref","unstructured":"Tsvetkov, Y.E., Paulovi\u010dov\u00e1, E., Paulovi\u010dov\u00e1, L., Farka\u0161, P., and Nifantiev, N.E. (2020). Synthesis of Biotin-Tagged Chitosan Oligosaccharides and Assessment of Their Immunomodulatory Activity. Front. Chem., 8.","DOI":"10.3389\/fchem.2020.554732"},{"key":"ref_86","doi-asserted-by":"crossref","unstructured":"Hu, D., Jin, Y., Hou, X., Zhu, Y., Chen, D., Tai, J., Chen, Q., Shi, C., Ye, J., and Wu, M. (2023). Application of Marine Natural Products against Alzheimer\u2019s Disease: Past, Present and Future. Mar. Drugs, 21.","DOI":"10.3390\/md21010043"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"137","DOI":"10.4162\/nrp.2021.15.2.137","article-title":"Role of n-3 long-chain polyunsaturated fatty acids in human nutrition and health: Review of recent studies and recommendations","volume":"15","year":"2021","journal-title":"Nutr. Res. Pract."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.plipres.2010.07.004","article-title":"Docosapentaenoic acid (22: 5n-3): A review of its biological effects","volume":"50","author":"Kaur","year":"2011","journal-title":"Prog. Lipid Res."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.semcancer.2016.08.004","article-title":"Anti-inflammatory effects of docosahexaenoic acid: Implications for its cancer chemopreventive potential","volume":"40\u201341","author":"Yum","year":"2016","journal-title":"Semin. Cancer Biol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev-food-111317-095850","article-title":"Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits","volume":"9","author":"Shahidi","year":"2018","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.mam.2017.12.004","article-title":"Brain docosahexaenoic acid uptake and metabolism","volume":"64","author":"Lacombe","year":"2018","journal-title":"Mol. Aspects Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/jcsm.12219","article-title":"A randomized clinical trial investigating the efficacy of targeted nutrition as adjunct to exercise training in COPD","volume":"8","author":"Rutten","year":"2017","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/MCO.0000000000000648","article-title":"Fish oil supplementation and maintaining muscle mass in chronic disease: State of the evidence","volume":"23","author":"Mazurak","year":"2020","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.clnesp.2021.10.011","article-title":"The effect of long chain omega-3 polyunsaturated fatty acids on muscle mass and function in sarcopenia: A scoping systematic review and meta-analysis","volume":"46","author":"Bird","year":"2021","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"220222","DOI":"10.1183\/16000617.0222-2022","article-title":"Pulmonary rehabilitation and physical interventions","volume":"32","author":"Troosters","year":"2023","journal-title":"Eur. Respir. Rev."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1136\/thx.2004.030858","article-title":"Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease","volume":"60","author":"Broekhuizen","year":"2005","journal-title":"Thorax"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/jcsm.12228","article-title":"Targeted medical nutrition for cachexia in chronic obstructive pulmonary disease: A randomized, controlled trial","volume":"9","author":"Calder","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"153201","DOI":"10.1016\/j.phymed.2020.153201","article-title":"Phytosterols of marine algae: Insights into the potential health benefits and molecular pharmacology","volume":"69","author":"Hannan","year":"2020","journal-title":"Phytomedicine"},{"key":"ref_99","unstructured":"PubChem (2025, March 06). Fucosterol | C29H48O | CID 5281328, Available online: https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/Fucosterol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.fct.2013.05.061","article-title":"Anti-inflammatory activity of edible brown alga Eisenia bicyclis and its constituents fucosterol and phlorotannins in LPS-stimulated RAW264.7 macrophages","volume":"59","author":"Jung","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Kirindage, K., Jayasinghe, A., Han, E.J., Jee, Y., Kim, H.J., Do, S.G., Fernando, I., and Ahn, G. (2022). Fucosterol Isolated from Dietary Brown Alga Sargassum horneri Protects TNF-\u03b1\/IFN-\u03b3-Stimulated Human Dermal Fibroblasts via Regulating Nrf2\/HO-1 and NF-\u03baB\/MAPK Pathways. Antioxidants, 11.","DOI":"10.3390\/antiox11081429"},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Jayawardena, T.U., Sanjeewa, K., Lee, H.G., Nagahawatta, D.P., Yang, H.W., Kang, M.C., and Jeon, Y.J. (2020). Particulate Matter-Induced Inflammation\/Oxidative Stress in Macrophages: Fucosterol from Padina boryana as a Potent Protector, Activated via NF-\u03baB\/MAPK Pathways and Nrf2\/HO-1 Involvement. Mar. Drugs, 18.","DOI":"10.3390\/md18120628"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s13659-024-00451-1","article-title":"Unveiling the molecular mechanisms: Dietary phytosterols as guardians against cardiovascular diseases","volume":"14","author":"El","year":"2024","journal-title":"Nat. Product. Bioprosp."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jss.2014.12.054","article-title":"Fucosterol attenuates lipopolysaccharide-induced acute lung injury in mice","volume":"195","author":"Li","year":"2015","journal-title":"J. Surg. Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.envres.2019.02.016","article-title":"Beijing urban particulate matter-induced injury and inflammation in human lung epithelial cells and the protective effects of fucosterol from Sargassum binderi (Sonder ex J. Agardh)","volume":"172","author":"Fernando","year":"2019","journal-title":"Environ. Res."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.clnesp.2018.09.076","article-title":"Effect of eicosapentaenoic acid on prevention of lean body mass depletion in patients with exacerbation of chronic obstructive pulmonary disease: A prospective randomized controlled trial","volume":"28","author":"Ogasawara","year":"2018","journal-title":"Clin. Nutr. ESPEN"},{"key":"ref_107","doi-asserted-by":"crossref","unstructured":"Pereira, L., and Cotas, J. (2023). Therapeutic Potential of Polyphenols and Other Micronutrients of Marine Origin. Mar. Drugs, 21.","DOI":"10.3390\/md21060323"},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Li, Y., Zheng, Y., Zhang, Y., Yang, Y., Wang, P., Imre, B., Wong, A., Hsieh, Y., and Wang, D. (2021). Brown Algae Carbohydrates: Structures, Pharmaceutical Properties, and Research Challenges. Mar. Drugs, 19.","DOI":"10.3390\/md19110620"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.fct.2010.03.001","article-title":"Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage","volume":"48","author":"Heo","year":"2010","journal-title":"Food Chem. Toxicol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"529","DOI":"10.3390\/md18110529","article-title":"Diphlorethohydroxycarmalol (DPHC) Isolated from the Brown Alga Ishige okamurae Acts on Inflammatory Myopathy as an Inhibitory Agent of TNF-\u03b1","volume":"18","author":"Kim","year":"2020","journal-title":"Mar. Drugs."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"106088","DOI":"10.1016\/j.phrs.2022.106088","article-title":"Pharmacological actions of dieckol on modulation of platelet functions and thrombus formation via integrin \u03b1(IIb)\u03b2(3) and cAMP signaling","volume":"177","author":"Irfan","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"111988","DOI":"10.1016\/j.biopha.2021.111988","article-title":"Dieckol: A brown algal phlorotannin with biological potential","volume":"142","author":"Rajan","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"175007","DOI":"10.1016\/j.scitotenv.2024.175007","article-title":"2,7-Phloroglucinol-6,6\u2019-bieckol from Ecklonia cava ameliorates nanoplastics-induced premature endothelial senescence and dysfunction","volume":"949","author":"Sim","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev-food-032818-121401","article-title":"Source, Extraction, Characterization, and Applications of Novel Antioxidants from Seaweed","volume":"10","author":"Jacobsen","year":"2019","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20463\/pan.2021.0014","article-title":"Effects of marine oligomeric polyphenols on body composition and physical ability of elderly individuals with sarcopenia: A pilot study","volume":"25","author":"Kwon","year":"2021","journal-title":"Phys. Act. Nutr."},{"key":"ref_116","doi-asserted-by":"crossref","unstructured":"Sable, R., Parajuli, P., and Jois, S. (2017). Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications. Mar. Drugs, 15.","DOI":"10.3390\/md15040124"},{"key":"ref_117","first-page":"437","article-title":"Oyster (Ostrea Plicatula Gmelin) Peptides Improve Exercise Endurance Capacity via Activating AMPK and HO-1","volume":"43","author":"Lin","year":"2024","journal-title":"J. Am. Nutr. Assoc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.3892\/ijmm.2015.2386","article-title":"Bioactive peptide from Pyropia yezoensis and its anti-inflammatory activities","volume":"36","author":"Lee","year":"2015","journal-title":"Int. J. Mol. Med."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Lee, M.K., Choi, J.W., Choi, Y.H., and Nam, T.J. (2019). Protective Effect of Pyropia yezoensis Peptide on Dexamethasone-Induced Myotube Atrophy in C2C12 Myotubes. Mar. Drugs, 17.","DOI":"10.3390\/md17050284"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3390\/md9020278","article-title":"Carotenoids in marine animals","volume":"9","author":"Maoka","year":"2011","journal-title":"Mar. Drugs"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Galasso, C., Corinaldesi, C., and Sansone, C. (2017). Carotenoids from Marine Organisms: Biological Functions and Industrial Applications. Antioxidants, 6.","DOI":"10.3390\/antiox6040096"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1007\/s12603-009-0053-6","article-title":"Low serum carotenoids are associated with a decline in walking speed in older women","volume":"13","author":"Alipanah","year":"2009","journal-title":"J. Nutr. Health Aging"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/gerona\/63.4.376","article-title":"Low plasma carotenoids and skeletal muscle strength decline over 6 years","volume":"63","author":"Lauretani","year":"2008","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.2147\/COPD.S432995","article-title":"The Associations Between Serum Vitamins and Carotenoids with Chronic Obstructive Pulmonary Disease: Results from the NHANES","volume":"18","author":"Zheng","year":"2023","journal-title":"Int. J. Chronic Obstr. Pulm. Dis."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1080\/07315724.2020.1815608","article-title":"Association of Carotenoid Intake with Pulmonary Function","volume":"40","author":"Jun","year":"2021","journal-title":"J. Am. Coll. Nutr."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3892\/mmr.2022.12816","article-title":"Biological and neurological activities of astaxanthin (Review)","volume":"26","author":"Si","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/advances\/nmaa143","article-title":"The Promising Effects of Astaxanthin on Lung Diseases","volume":"12","author":"Cheng","year":"2021","journal-title":"Adv. Nutr. Int. Rev. J."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/mnfr.201000414","article-title":"Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae","volume":"55","author":"Yuan","year":"2011","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1021\/np050354+","article-title":"Astaxanthin, a carotenoid with potential in human health and nutrition","volume":"69","author":"Hussein","year":"2006","journal-title":"J. Nat. Prod."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.nutres.2017.10.006","article-title":"Continuous astaxanthin intake reduces oxidative stress and reverses age-related morphological changes of residual skin surface components in middle-aged volunteers","volume":"48","author":"Chalyk","year":"2017","journal-title":"Nutr. Res."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"114230","DOI":"10.1016\/j.biopha.2023.114230","article-title":"Astaxanthin attenuates cigarette smoking-induced oxidative stress and inflammation in a sirtuin 1-dependent manner","volume":"159","author":"Deng","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"115471","DOI":"10.1016\/j.biopha.2023.115471","article-title":"Astaxanthin attenuated cigarette smoke extract-induced apoptosis via decreasing oxidative DNA damage in airway epithelium","volume":"167","author":"Tang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Kubo, H., Asai, K., Kojima, K., Sugitani, A., Kyomoto, Y., Okamoto, A., Yamada, K., Ijiri, N., Watanabe, T., and Hirata, K. (2019). Astaxanthin Suppresses Cigarette Smoke-Induced Emphysema through Nrf2 Activation in Mice. Mar. Drugs, 17.","DOI":"10.3390\/md17120673"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"108364","DOI":"10.1016\/j.abb.2020.108364","article-title":"Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin","volume":"686","author":"Miyashita","year":"2020","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/jn\/119.1.105","article-title":"Provitamin A function of carotenoids: The conversion of beta-carotene into vitamin A","volume":"119","author":"Olson","year":"1989","journal-title":"J. Nutr."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.mam.2005.10.001","article-title":"Carotenoid actions and their relation to health and disease","volume":"26","author":"Krinsky","year":"2005","journal-title":"Mol. Aspects Med."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1079\/BJN2000248","article-title":"Serum concentrations of carotenoids and vitamins A, E, and C in control subjects from five European countries","volume":"85","author":"Olmedilla","year":"2001","journal-title":"Br. J. Nutr."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s40495-019-00168-7","article-title":"\u03b2-Cryptoxanthin: Chemistry, occurrence, and potential health benefits","volume":"5","author":"Jiao","year":"2019","journal-title":"Curr. Pharmacol. Rep."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.3390\/md13106226","article-title":"Marine Carotenoids against Oxidative Stress: Effects on Human Health","volume":"13","author":"Gammone","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1016\/j.tjnut.2024.08.020","article-title":"Low Serum Total Carotenoids and \u03b2-Cryptoxanthin Are Associated with Low Lean Body Mass in Older Community-Dwellers in the National Institute for Longevity Sciences-Longitudinal Study of Aging: A 4-Y Longitudinal Study","volume":"154","author":"Yamaguchi","year":"2024","journal-title":"J. Nutr."},{"key":"ref_141","doi-asserted-by":"crossref","unstructured":"Cooke, M.C., Coates, A.M., Buckley, E.S., and Buckley, J.D. (2018). Lutein Intake and Blood Lutein Concentration Are Positively Associated with Physical Activity in Adults: A Systematic Review. Nutrients, 10.","DOI":"10.3390\/nu10091186"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3390\/nu6030974","article-title":"Increases in plasma lutein through supplementation are correlated with increases in physical activity and reductions in sedentary time in older adults","volume":"6","author":"Thomson","year":"2014","journal-title":"Nutrients"},{"key":"ref_143","doi-asserted-by":"crossref","unstructured":"Matsumoto, M., Hagio, M., Inoue, R., Mitani, T., Yajima, M., Hara, H., and Yajima, T. (2014). Long-term oral feeding of lutein-fortified milk increases voluntary running distance in rats. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093529"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"110561","DOI":"10.1016\/j.nut.2019.110561","article-title":"Combined intake of astaxanthin, \u03b2-carotene, and resveratrol elevates protein synthesis during muscle hypertrophy in mice","volume":"69","author":"Kawamura","year":"2020","journal-title":"Nutrition"},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13068-024-02527-z","article-title":"Synergistic and stepwise treatment of resveratrol and catechol in Haematococcus pluvialis for the overproduction of biomass and astaxanthin","volume":"17","author":"Qiu","year":"2024","journal-title":"Biotechnol. Biofuels Bioprod."},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Kawamura, A., Aoi, W., Abe, R., Kobayashi, Y., Kuwahata, M., and Higashi, A. (2021). Astaxanthin-, \u03b2-Carotene-, and Resveratrol-Rich Foods Support Resistance Training-Induced Adaptation. Antioxidants, 10.","DOI":"10.3390\/antiox10010113"},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1006\/abbi.2000.2149","article-title":"Antioxidant and prooxidant properties of carotenoids","volume":"385","author":"Young","year":"2001","journal-title":"Arch. Biochem. Biophys."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.3390\/md10122634","article-title":"Chemical composition and antioxidant\/antimicrobial activities in supercritical carbon dioxide fluid extract of Gloiopeltis tenax","volume":"10","author":"Zheng","year":"2012","journal-title":"Mar. Drugs"},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"8068","DOI":"10.1096\/fj.201902399RR","article-title":"Undaria pinnatifida extract feeding increases exercise endurance and skeletal muscle mass by promoting oxidative muscle remodeling in mice","volume":"34","author":"Ahn","year":"2020","journal-title":"FASEB J."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"129463","DOI":"10.1016\/j.foodchem.2021.129463","article-title":"Identifying Codium fragile extract components and their effects on muscle weight and exercise endurance","volume":"353","author":"Ahn","year":"2021","journal-title":"Food Chem."},{"key":"ref_151","doi-asserted-by":"crossref","unstructured":"Oh, S., Choi, C.H., Lee, B.J., Park, J.H., Son, K.H., and Byun, K. (2021). Fermented Oyster Extract Attenuated Dexamethasone-Induced Muscle Atrophy by Decreasing Oxidative Stress. Molecules, 26.","DOI":"10.3390\/molecules26237128"},{"key":"ref_152","doi-asserted-by":"crossref","unstructured":"Kim, S.H., Leem, Y.E., Park, H.E., Jeong, H.I., Lee, J., and Kang, J.S. (2024). The Extract of Gloiopeltis tenax Enhances Myogenesis and Alleviates Dexamethasone-Induced Muscle Atrophy. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms25126806"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41419-021-04469-y","article-title":"BNIP3L\/NIX-mediated mitophagy: Molecular mechanisms and implications for human disease","volume":"13","author":"Li","year":"2021","journal-title":"Cell Death Dis."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"106055","DOI":"10.1016\/j.phrs.2021.106055","article-title":"Polypharmacology: The science of multi-targeting molecules","volume":"176","author":"Kabir","year":"2022","journal-title":"Pharmacol. Res."},{"key":"ref_155","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1080\/10408398.2020.1839855","article-title":"Bioactive functional ingredients from aquatic origin: A review of recent progress in marine-derived nutraceuticals","volume":"62","author":"Hosseini","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Cotas, J., Leandro, A., Monteiro, P., Pacheco, D., Figueirinha, A., Gon\u00e7alves, A., Da, S.G., and Pereira, L. (2020). Seaweed Phenolics: From Extraction to Applications. Mar. Drugs, 18.","DOI":"10.3390\/md18080384"},{"key":"ref_157","doi-asserted-by":"crossref","unstructured":"Stromsnes, K., Lagzdina, R., Olaso-Gonzalez, G., Gimeno-Mallench, L., and Gambini, J. (2021). Pharmacological properties of polyphenols: Bioavailability, mechanisms of action, and biological effects in in vitro studies, animal models, and humans. Biomedicines, 9.","DOI":"10.3390\/biomedicines9081074"},{"key":"ref_158","doi-asserted-by":"crossref","first-page":"S194","DOI":"10.1002\/mnfr.200800053","article-title":"Carotenoids: Actual knowledge on food sources, intakes, stability and bioavailability and their protective role in humans","volume":"53","author":"Maiani","year":"2009","journal-title":"Mol. Nutr. Food Res."},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"107798","DOI":"10.1016\/j.bej.2020.107798","article-title":"Isolation and purification of brown algae fucoidan from Sargassum siliquosum and the analysis of anti-lipogenesis activity","volume":"165","author":"Wang","year":"2021","journal-title":"Biochem. Eng. J."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/4\/158\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T17:10:11Z","timestamp":1760029811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/4\/158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,4]]},"references-count":159,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,4]]}},"alternative-id":["md23040158"],"URL":"https:\/\/doi.org\/10.3390\/md23040158","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,4]]}}}