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Their structures and stereochemistries were elucidated through detailed NMR and MS analyses, calculated electronic circular dichroism, and comparison with previously reported data. Compound 1 demonstrated inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells, with an IC50 value of 62.9 \u00b5M, and more effectively suppressed the expression of interleukin (IL)-6 than dexamethasone. A further mechanistic study suggested that 1 could prohibit the expression of iNOS in RAW 264.7 cells, and the molecular docking study suggested a possible interaction between 1 and the iNOS protein. Compounds 7 and 8 exhibited moderate to potent DPPH radical scavenging activity, with IC50 values of 117.4 and 46.2 \u00b5M, respectively, compared with the positive control ascorbic acid (IC50 = 45.6 \u00b5M). Compounds 4 and 10 showed ABTS+ radical scavenging activity, with IC50 values of 66.6 and 33.2 \u00b5M, respectively, which were equal to or lower than that of the positive control vitamin C (IC50 = 59.7 \u00b5M). Compounds 1\u20133, 7, and 9 showed antibacterial activity against three Staphylococcus aureus strains, with MIC values of 74.4\u2013390.6 \u03bcM.<\/jats:p>","DOI":"10.3390\/md23060238","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:34:13Z","timestamp":1748853253000},"page":"238","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["New Bioactive Polyketides from the Mangrove-Derived Fungus Daldinia eschscholzii HJX1P2"],"prefix":"10.3390","volume":"23","author":[{"given":"Miao","family":"Yu","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, 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Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Gong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, 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